Dynamics of immunologic parameters in elder children with atopic dermatitis

1999 ◽  
Vol 80 (4) ◽  
pp. 253-255
Author(s):  
В. А. Shamov ◽  
A. G. Shamova ◽  
T. G. Malanicheva
Keyword(s):  
Atopic Dermatitis ◽  
Immune Complexes ◽  
Immune Status ◽  
Circulating Immune Complexes ◽  
Natural Killers ◽  
Cd8 Cells ◽  
Immunologic Parameters

In children aged 10 to 17 with atopic dermatitis the following changes are revealed: the decrease of the content of CD3+-cells, CD8+-cells, natural killers, CH50, the increase of immunoregulator index indicators, CD19+-cells, igg, ige circulating immune complexes. More pronounced disorders of the immune status are found in boys and girls aged 13 to 17 than in children aged 10 to 12. After the treatment the favourable dynamics of the indicators of CD8+-cells, immunoregulator index, concentration of igg, ige and circulating immune complexes is found.

scholarly journals The effect of interferons-α and –γ and their combination with dimethyl dipyrazolyl selenide on the immune status and functional state of the reproductive system of cows in adverse ecological conditions

2019 ◽  
pp. 53-57
Author(s):  
A. G. Shakhov ◽  
I. T. Shaposhnikov ◽  
Yu. N. Brigadirov ◽  
V. N. Kotsarev ◽  
V. N. Skorikov ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Functional State ◽  
Reproductive System ◽  
Immune Complexes ◽  
Immune Status ◽  
Lysozyme Activity ◽  
Circulating Immune Complexes ◽  
Control Group ◽  
Ecological Conditions ◽  
Positive Effect

The results of studying the effect of interferons alpha and gamma and their combination with dimethyl dipyrazolyl selenide on the immune status and functional state of the reproductive system of cows in adverse ecological conditions are presented. The positive effect of the drugs, especially their combination, on erythropoiesis and the immune status of animals, which was manifested by an increase in the content of erythrocytes, hemoglobin, hematocrit, leukocytes, total immunoglobulins, serum bactericidal and lysozyme activity, absorptive function of phagocytes, relative amount of T lymphocytes, and a decrease in the level of circulating immune complexes was stated. An increase in the immune status of animals at the effect of immunocorrecting drugs was accompanied by a decrease in the pathology of calving and postpartum complications and favorably affected the functional state of their reproductive system. The cows which were introduced interferons and their combination with dimethyl dipyrazolyl selenide demonstrated a shorter period from calving to successful insemination, as well as the insemination index and fertility, compared with the animals of the control group, which were not introduced any drugs.

scholarly journals Immune related prognosis biomarkers for outcomes of joint preservation surgery in children with ischemic deformity of the proximal femur (preliminary results)

2020 ◽  
Vol 26 (4) ◽  
pp. 516-520
Author(s):  
M.P. Teplenky ◽  
◽  
M.V. Chepeleva ◽  
E.I. Kuznetsova ◽  
◽  
...  
Keyword(s):  
Proximal Femur ◽  
Immune Complexes ◽  
Immune Status ◽  
Circulating Immune Complexes ◽  
Immunological Parameters ◽  
Humoral Immune ◽  
Joint Preservation ◽  
Group I ◽  
Low Levels ◽  
Group Ii

Objective Assess the immune status of children with ischemic deformity of the proximal femur taking into account the treatment outcome. Material and methods Preoperative assessment of the immune status was performed for 16 adolescents with ischemic deformity of the proximal femur. Patients' age was 14.4 ± 0.45 years. Immunological parameters of 12 adolescents with satisfactory (group I) and 4 patients with poor (group II) anatomical and functional outcome of surgical treatment were compared. Peripheral blood lymphocyte typing was produced with laser cytometry assay, and IgA, IgM, IgG, IgE, IL-18, IFNγ and circulating immune complexes were quantified with enzyme-linked immunoassay. Results Сomparative analysis of preoperative immunological parameters showed statistically significant decline of Т-helper cells (СD3+СD4+), high levels of activated СD3+CD25 and СD3+HLADR T lymphocytes, low levels of activated NК cells (СD8dimCD38+) and IFNγ in group II. Humoral immune parameters indicated to low levels of IgA, IgM, IgG and higher levels of circulating immune complexes in group II relative to group I. Conclusion Preliminary data obtained suggest that cellular and humoral immune deficiency can be associated with unfavorable outcome of joint preservation procedure. Such immunological parameters as T lymphocytes subpopulation, immunoglobulins, circulating immune complexes and IFNγ can be used as significant prognostic factors for preoperative planning and postoperative rehabilitation of adolescents with ischemic deformity of the proximal femur.

scholarly journals Immune complexes in blood serum of calves with clinical symptoms of bronchopneumonia

2011 ◽  
Vol 65 (1-2) ◽  
pp. 13-24
Author(s):  
Natalija Fratric ◽  
Dragan Gvozdic ◽  
Olivera Savic ◽  
Ivana Jaglicic ◽  
Vesna Ilic
Keyword(s):  
Immune Complexes ◽  
Immune Status ◽  
Clinical Symptoms ◽  
Electrophoretic Analysis ◽  
Circulating Immune Complexes ◽  
Infectious Agents ◽  
Diagnostic Parameter ◽  
Environment Management ◽  
Additional Diagnostic Parameter

Pneumonia in preruminant calves is a multifactorial disease. Infectious agents, the environment, management and the immune status of the calves are all important factors in determining the outcome of an infection. Until today, the level and composition of circulating immune complexes in preruminant calves with pneumonia have not been studied in detail. We performed this work with the aim to determine whether pneumonia in three-month-old calves is followed by changes in the immune complex level and changes in the ?-globulin level as their possible constituents. Immune complexes from the calves? sera were isolated by polyethylene glycol (PEG) precipitation methods. Optical density at 350 nm (OD350) of redissolved precipitates was measured to determine the circulating immune complexes level. The OD350 level of PEG precipitates of calves with pneumonia at the time of diagnosis was 0.577?0.206 and it was statistically significantly higher (p<0.001) than OD350 the level of PEG precipitates of healthy calves (0.286?0.080). Electrophoretic analysis of sera and PEG precipitates showed that both slow and fast ?-globulins are found among serum and immune-complexes' ?-globulins, but the concentration of fast ?-globulins was significantly lower in sera of diseased calves. The level of PEG precipitable immune complexes was not correlated with the concentration of serum and PEG precipitable g-globulins. The results of this study have shown that by relatively simple PEG precipitation assay it is possible to detect an increased level of circulating immune complexes in calves with pneumonia. This can be used as an additional diagnostic parameter for the detection and follow up of the disease.

Persistence and Progression of Immunologic Abnormalities in Haemophilia

1985 ◽  
Vol 53 (03) ◽  
pp. 328-331 ◽  
Author(s):  
Joan C Gill ◽  
Dana Wheeler ◽  
Jay E Menitove ◽  
Richard H Aster ◽  
James T Casper ◽  
...  
Keyword(s):  
Immune Complexes ◽  
Circulating Immune Complexes ◽  
Mean Values ◽  
Immunologic Parameters

SummaryImmunologic parameters in 51 patients with haemophilia treated with cryoprecipitate from volunteer donors or with commercial lyophilized concentrate were studied on 2–7 occasions. Concentrate users had significantly decreased mean T4 (helper)/T8 (suppressor) lymphocyte ratios when the initial (1.5 ± .43) and most recent (1.25 ± .60) values were compared (p <.001), whereas in cryoprecipitate users mean values remained normal. Of the 22 concentrate users with initially normal T4/T8 ratios, 10 became abnormal during the study, an incidence of 45%. Fifteen of 28 (54%) patients with abnormal T4/T8 ratios had elevated circulating immune complexes (CIC), whereas all 16 patients with normal T4/T8 ratios had normal levels of CIC. Six patients have persistent lymphadenopathy.

scholarly journals The evolution of the immune status in patients with chronic obstructive pulmonary disease after using enterosorption

2015 ◽  
Vol 17 (3) ◽  
Author(s):  
S. V. Lototska ◽  
S. M. Andreychyn ◽  
V. M. Meretskyi
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Immune Complexes ◽  
Immune Status ◽  
Immunoglobulin E ◽  
Circulating Immune Complexes ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Serum Lysozyme ◽  
Positive Effect

<p>The are presented the results of research indicators of immunological status in patients with chronic obstructive<br />pulmonary disease after incluing in the complex therapy of diseases enterosorbents “Enterosgel” or “Karbolayn”.<br />Received results showed that the disease is accompanied by increased levels of circulating immune complexes<br />and immunoglobulin E content and a decrease in serum lysozyme. Enterosorption marked positive effect on the<br />background of the basic treatment of patients with chronic obstructive pulmonary disease as evidenced by the reduction<br />of circulating immune complexes and immunoglobulin E and rising of lysozyme. After conducting a comparative<br />analysis of two sorbents we found that carbon sorbent was more efficient.</p>

Characteristic of the immune status in persons working with videoterminals

1993 ◽  
Vol 74 (3) ◽  
pp. 220-222
Author(s):  
N. H. Amirov ◽  
L. M. Fatkhutdinova ◽  
V. N. Krasnoshchokova
Keyword(s):  
Immune System ◽  
Psychosocial Factors ◽  
Immune Complexes ◽  
Immune Status ◽  
Work Satisfaction ◽  
Circulating Immune Complexes ◽  
Considerable Influence ◽  
Basic Group

The content of immunoglobulins (IgG, IgA, IgM) as well as circulating immune complexes (CIC) is determined in the blood scrum of 58 programmers working with videodisolay terminals (VDT) and 19 employees not working or seldom using VDT. The higher IgG and IgA levels are revealed, with most of the persons having the exceeding norm of IgA and CIC values in the basic group. The considerable influence of work satisfaction on IgA and IgM levels and expression degree of working and chronic organization stress on CIC levels is revealed: index levels being lower at work satisfaction and at low values of stress scales. The influence of the electromagnetic 9200 kHz range fields on the indices of the immune status is not detected. It is concluded that the immune system is made more active at work with VDT and the psychosocial factors are of great importance in this process.

PARTICULARITIES OF THE IMMUNE RESPONSE IN PERSONS PROFESSIONNALLY EXPOSED TO BERYLLIUM

2016 ◽  
pp. 26-30
Author(s):  
K. I. Stosman ◽  
L. V. Lukovnikova
Keyword(s):  
Immune Response ◽  
Immune Complexes ◽  
Immunoglobulin E ◽  
Circulating Immune Complexes ◽  
Professional Contact ◽  
Beryllium Compounds

An examination was performed of 50 employees at an enterprise where they were in professional contact with beryllium. In most workers, it was detected an increase of interleukine-8, interferon- , growing level of immunoglobulin E and circulating immune complexes. It was shown that the contact with beryllium compounds leads to the interferon- level growth only in women. In men, alterations are identified in the direction of increased concentrations of common immunoglobulin E and circulating immune complexes.

Isolation of Circulating Immune Complexes from TB Patient Serum for Serodiagnosis

BIO-PROTOCOL ◽  
2012 ◽  
Vol 2 (11) ◽  
Author(s):  
Uma Ranganathan ◽  
Ramalingam Bethunaickan ◽  
Alamelu Raja
Keyword(s):  
Immune Complexes ◽  
Circulating Immune Complexes

scholarly journals Role of Circulating Immune Complexes in the Pathogenesis of Canine Leishmaniasis: New Players in Vaccine Development

2021 ◽  
Vol 9 (4) ◽  
pp. 712
Author(s):  
Cristina Cacheiro-Llaguno ◽  
Nuria Parody ◽  
Marta R. Escutia ◽  
Jerónimo Carnés
Keyword(s):  
Immune Complexes ◽  
Vaccine Development ◽  
Correct Diagnosis ◽  
Circulating Immune Complexes ◽  
Response To Treatment ◽  
Canine Leishmaniasis ◽  
Leishmania Infection ◽  
Serum Samples ◽  
Humoral Immune

During canine visceral leishmaniasis (CanL), due to Leishmania infantum (L. infantum), uncontrolled infection leads to a strong humoral immune response. As a consequence of the production of high antibody levels and the prolonged presence of parasite antigens, circulating immune complexes (CIC) are formed, which can be deposited in certain organs and tissues, inducing vasculitis, uveitis, dermatitis and especially glomerulonephritis and renal failure. A method to detect CIC and quantify their levels in serum samples from dogs infected with L. infantum has been recently described. It allowed demonstration of a correlation between CIC levels and disease severity. Thus, CIC measurement may be useful for diagnosis, assessment of disease progression and monitoring response to treatment. This is an interesting finding, considering that there remains an urgent need for identification of novel biomarkers to achieve a correct diagnosis and for optimal disease staging of dogs suffering from Leishmania infection. The objective of the present review is to shed light on the role of CIC in CanL, as well as to highlight their potential use not only as diagnostic and prognostic biomarkers but also as a valuable tool in vaccine development and new immunotherapy strategies to prevent or control disease outcome.

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