Clinical aspects of morphological investigation of fetal thyroid glands

2021 ◽  
Vol 50 (2) ◽  
pp. 72-75
Author(s):  
O. K. Khmelnitskii ◽  
A. Ju. Ivanova ◽  
I. I. Evsyukova
Keyword(s):  
Clinical Aspects ◽  
Morphological Investigation ◽  
Adaptive Function ◽  
Saint Petersburg ◽  
Thyroid Glands ◽  
Fetal Thyroid ◽  
Practical Recommendations

The investigation of 121 thyroid glands offetuses and neonates of mothers who live in Saint-Petersburg was carried out. The paper analyzes intra and postnatal fatal outcomes taking account оf gestational andpostnatal age. The role of thyroid glands adaptive function emaciation in thanatogenesis in case of asphyxia was demonstrated. On the basis of the study practical recommendations are suggested.

Towards Coherent European Crime Victims Policies and Practices

2019 ◽  
Vol 25 (2) ◽  
pp. 122-127
Author(s):  
Dobrinka Chankova ◽  
Gergana Georgieva
Keyword(s):  
Domestic Violence ◽  
Crime Victims ◽  
Political Factors ◽  
Victims Of Crime ◽  
Victim Protection ◽  
National Governments ◽  
Protection Order ◽  
Practical Recommendations ◽  
Policies And Practices

Abstract This study explores the latest developments on the European scale of the policies and practices towards victims of crime. Due to many economic and political factors a lot of people are in movement and exposed to the risk of becoming victims of crime. During the last decade the statistics already records enhanced victimization of the global European society. These have provoked numerous legislative actions and practical initiatives in order to ensure safety, to prevent falling victims to crime and to protect better victim’s rights and needs. The European Protection Order Directive, Victims’ Directive and Convention against domestic violence, are among the most advanced legal acts worldwide. However, it is observed that their implementation in Europe is asymmetric and sometimes problematic. This paper explores the role of the national governments and specialized agencies and mainly the deficits in their activities leading to the non-usage of victims of all the existing opportunities. The newest supra-national acts aiming at the acceleration of transposition and ratification of these important for the building of victim-friendly environment documents, are discussed. Practical recommendations for a more effective victim protection are developed.

scholarly journals Caspase-14—From Biomolecular Basics to Clinical Approach. A Review of Available Data

2021 ◽  
Vol 22 (11) ◽  
pp. 5575
Author(s):  
Agnieszka Markiewicz ◽  
Dawid Sigorski ◽  
Mateusz Markiewicz ◽  
Agnieszka Owczarczyk-Saczonek ◽  
Waldemar Placek
Keyword(s):  
Cell Death ◽  
Physiological Role ◽  
Skin Barrier ◽  
Clinical Aspects ◽  
Clinical Approach ◽  
Search Term ◽  
Caspase Family ◽  
Skin Conditions ◽  
Theoretical Science

Caspase-14 is a unique member of the caspase family—a family of molecules participating in apoptosis. However, it does not affect this process but regulates another form of programmed cell death—cornification, which is characteristic of the epidermis. Therefore, it plays a crucial role in the formation of the skin barrier. The cell death cycle has been a subject of interest for researchers for decades, so a lot of research has been done to expand the understanding of caspase-14, its role in cell homeostasis and processes affecting its expression and activation. Conversely, it is also an interesting target for clinical researchers searching for its role in the physiology of healthy individuals and its pathophysiology in particular diseases. A summary was done in 2008 by Denecker et al., concentrating mostly on the biotechnological aspects of the molecule and its physiological role. However, a lot of new data have been reported, and some more practical and clinical research has been conducted since then. The majority of studies tackled the issue of clinical data presenting the role of caspase in the etiopathology of many diseases such as retinal dysfunctions, multiple malignancies, and skin conditions. This review summarizes the available knowledge on the molecular and, more interestingly, the clinical aspects of caspase-14. It also presents how theoretical science may pave the way for medical research. Methods: The authors analyzed publications available on PubMed until 21 March 2021, using the search term “caspase 14”.

Diabetic neuropathy: Epidemiological, pathogenetic, and clinical aspects with special emphasis on type 2 diabetes mellitus

1983 ◽  
Vol 104 (4_Suppl) ◽  
pp. S89-S94
Author(s):  
E. Matikainen ◽  
J. Juntunen
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Peripheral Neuropathy ◽  
Diabetic Control ◽  
Clinical Aspects ◽  
Type 2 Diabetics ◽  
Insulin Dependent

ABSTRACT. Peripheral neuropathy is a frequent complication of diabetes mellitus. Alterations of the peripheral nervous system in diabetics have been studied in numerous investigations. There are many factors known to participate in the development of this complication, e.g. the age of the patient, duration of the diabetes, quality of the diabetic control etc. The role of different types of diabetes in development of neuropathy is still largely unclear since investigations on this aspect are few. It seems, however, that peripheral neuropathy in type 2 (non-insulin dependent) diabetes is common but often mild. The differential diagnosis of the peripheral neuropathy in type 2 diabetics is more difficult than in type 1 (insulin dependent) diabetics, since these patients tend to be older and also may have other concomitant disorders. In this paper the clinical features and pathogenetic mechanisms of neuropathy in type 2 diabetes are briefly discussed.

scholarly journals The role of concepts in science teaching

2003 ◽  
pp. 111-130
Author(s):  
Slobodanka Milanovic-Nahod ◽  
Nadezda Saranovic-Bozanovic ◽  
Dragica Sisovic
Keyword(s):  
Primary School ◽  
Concept Learning ◽  
Efficient Method ◽  
Cognitive Structure ◽  
School Level ◽  
Scientific Concepts ◽  
Essential Questions ◽  
Practical Recommendations ◽  
Primary School Level

The present paper poses essential questions: What knowledge should students attain and what methods should be applied? The authors started up from cognitivistic view of cognition related to: (a) organizing knowledge of science in the form of generalized ideas or major concepts that can be reduced to a large number of information items, and (b) manner of building up students? knowledge into meaningful units as matrices of interrelated concepts. Attention is directed to difficulties emerging in developing cognitive structures related to complex contents of science and methods of concept learning in the teaching process. The results of investigations show that students? mastery of concepts is poor, and the reasons are to be found in the abstract character of contents themselves, lack of ability to interrelate contents within one discipline and between cognate ones, and the absence of establishing relationships between scientific concepts in cognitive structure. An efficient method of presenting scientific concepts was given and explained at three levels, such as macro, micro and symbolic. A model was suggested as a possible method for netting concepts in chemistry at primary school level. Practical recommendations were given to teachers how to assess students? cognitive structure and how to apply appropriate methods.

scholarly journals Barriers in Implementing the Dying Patient Law: The Israeli Experience - A Qualitative Study

2020 ◽  
Author(s):  
Avi Zigdon ◽  
Rachel Nissanholtz-Gannot
Keyword(s):  
End Of Life ◽  
Family Doctor ◽  
Clinical Aspects ◽  
Human Aspects ◽  
Life Issues ◽  
End Of Life Issues ◽  
Medical Teams ◽  
Depth Interviews ◽  
Training Physicians

Abstract Background Coping with end-of-life issues is a major challenge for governments and health systems. Despite progress in legislation, many barriers exist to its full implementation. This study is aimed at identifying these end-of-life barriers in relation to Israel.Methods Qualitative in-depth interviews using professionals and decision makers in the health-care and related systems (n=37) were carried out, along with two focus groups based on brainstorming techniques consisting of nurses (n=10) and social workers (n=10). Data was managed and analyzed using Naralyzer software.Results Qualitative analysis showed identification of six primary barriers: 1) law, procedures, and forms; 2) clinical aspects; 3) human aspects; 4) knowledge and skills of medical teams; 5) communication; and 6) resource allocation. These were further divided into 44 sub area barriers.Conclusions This study highlights the role of the family doctor in end-of-life by training physicians in decision-making workshops and increasing their knowledge in the field of palliative medicine. Effectively channeling resources, knowledge, and support for medical teams, by accounting for the structure and response of the units for home treatment will improve patient's access to information on and support for end-of-life laws, as well as reduce legislative barriers in other countries that face the same issues.

scholarly journals Preparation for Independent Life of People with ASD and Other Developmental Disorders in The Autonomous Noncommercial Organization «Adain Lo» (ANO «Adain Lo»).

2018 ◽  
Vol 16 (1) ◽  
pp. 29-35
Author(s):  
A.A. Ginsburg ◽  
M.E. Gitshabash ◽  
Ya.L. Ivanova
Keyword(s):  
Developmental Disorders ◽  
Autism Spectrum ◽  
Adults With Autism ◽  
Saint Petersburg ◽  
Independent Life ◽  
Spectrum Disorders ◽  
Self Service ◽  
Role Of Parents ◽  
Commercial Organization

The problems of preparation of children and adults with autism spectrum disorders and other developmental disabilities for independent life, modern ways of development of their independence are considered. The role of parents in this process and parent-specialist interaction are stressed. The techniques of tutor support, parents and other specialists are described. Presented techniques are realized in autonomous non-commercial organization «Adain Lo» (Saint-Petersburg) and aimed for maintenance of independent life, self-service, game, communication and education of people with special needs.

scholarly journals Clinical Aspects of Bacterial Corneal Ulcer Prolonged Course, the Role of Herpes Viruses in Its Pathogenesis, Treatment

2019 ◽  
Vol 16 (1S) ◽  
pp. 40-44
Author(s):  
V. V. Neroev ◽  
L. A. Katargina ◽  
L. A. Kovaleva ◽  
G. I. Krichevskaya ◽  
N. V. Balatskaya
Keyword(s):  
Corneal Ulcer ◽  
Human Herpesvirus ◽  
Clinical Aspects ◽  
Herpesvirus Type ◽  
Corneal Ulcers ◽  
Barr Virus ◽  
Human Herpesvirus Type ◽  
Epstein Barr ◽  
Simplex Virus

Purpose: to study the role of human herpesviruses (HHV) in the pathogenesis of prolonged bacterial corneal ulcers. Patients and methods. 117 patients with bacterial corneal ulcer were examined. Two groups were identified: a favorable course-with duration of bacterial corneal ulcer epithelialization for 17 days (62 people) and a prolonged course with a persistent ulcer more than 17 days (55 people). Blood samples (n = 117) and scrapes from corneal ulcer (n = 117) were investigated in polymerase chain reaction (PCR) for the presence of deoxyribonucleic acid (DNA) of Herpes simplex virus (HSV1, 2), Epstein-Barr virus (EBV), Human herpesvirus type 6, 7 (HHV-6, HSV-7). Results. The HSV1, 2 and EBV genomes were detected in the cornea significantly more often in BCU of prolonged course compared with a favorable course (HSV1, 2 p = 0.012; EBV p = 0.012), and HHV-6 was detected not only in the cornea (p = 0.000), but also and in blood (p = 0.007). In patients with HHV DNA in corneal scarps and/or blood, after resorption of purulent infiltrate, corneal epithelialization was absent, and the use of antiherpetic drugs allowed to reduce the completion time of BCU epithelialization. Conclusion. The role of HHV-6, EBV, HSV 1, 2 in the pathogenesis of bacterial corneal ulcer of protracted course was revealed. The expediency of examination of patients with bacterial corneal ulcer on HHV is shown, a method of treatment is proposed, including antiherpetic therapy, which makes it possible to prevent the development of a protracted course.

scholarly journals ANMCO POSITION PAPER: Role of intra-aortic balloon pump in patients with acute advanced heart failure and cardiogenic shock

2021 ◽  
Vol 23 (Supplement_C) ◽  
pp. C204-C220
Author(s):  
Roberta Rossini ◽  
Serafina Valente ◽  
Furio Colivicchi ◽  
Cesare Baldi ◽  
Pasquale Caldarola ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cardiogenic Shock ◽  
Acute Heart Failure ◽  
Advanced Heart Failure ◽  
Position Paper ◽  
Present Position ◽  
Intra Aortic Balloon Pump ◽  
All Cause Mortality ◽  
Practical Recommendations

Abstract The treatment of patients with advanced acute heart failure is still challenging. Intra-aortic balloon pump (IABP) has widely been used in the management of patients with cardiogenic shock. However, according to international guidelines, its routinary use in patients with cardiogenic shock is not recommended. This recommendation is derived from the results of the IABP-SHOCK II trial, which demonstrated that IABP does not reduce all-cause mortality in patients with acute myocardial infarction and cardiogenic shock. The present position paper, released by the Italian Association of Hospital Cardiologists, reviews the available data derived from clinical studies. It also provides practical recommendations for the optimal use of IABP in the treatment of cardiogenic shock and advanced acute heart failure.

Venous Thromboembolic Diseases

2014 ◽  
pp. 346-355
Author(s):  
Gregory Piazza ◽  
Samuel Z. Goldhaber
Keyword(s):  
Risk Factors ◽  
High Risk ◽  
Risk Stratification ◽  
Laboratory Testing ◽  
Clinical Findings ◽  
Venous Thromboembolic ◽  
Long Term Consequences ◽  
Practical Recommendations

This chapter reviews the pathophysiology of VTE, including its risk factors and long-term consequences. Diagnostic algorithms that integrate clinical findings, laboratory testing, and imaging are described. The role of risk stratification for identification of high-risk PE patients is highlighted. Options for the management of VTE are reviewed. Finally, practical recommendations for the prevention of VTE are provided.

scholarly journals No evidence for an adaptive role of early molt into breeding plumage in a female fairy wren

2019 ◽  
Vol 31 (2) ◽  
pp. 411-420
Author(s):  
Sergio Nolazco ◽  
Michelle L Hall ◽  
Sjouke A Kingma ◽  
Kaspar Delhey ◽  
Anne Peters
Keyword(s):  
Mating Systems ◽  
Reproductive Effort ◽  
Adaptive Function ◽  
Female Ornamentation ◽  
Extrapair Mating ◽  
Study Results ◽  
Selection For ◽  
Breeding Plumage ◽  
Adaptive Role

Abstract The evolution of ornaments as sexually selected signals is well understood in males, but female ornamentation remains understudied. Fairy wrens offer an excellent model system, given their complex social structure and mating systems, and the diversity of female ornamentation. We investigated whether early molt into ornamental breeding plumage plays an adaptive role in females of the monogamous purple-crowned fairy wren Malurus coronatus, the only fairy wren known to have female seasonal plumage. Using 6 years of monitoring, we found that the timing of female molt was similar to males, but there was no evidence for assortative mating. Like males (previous study), older and dominant individuals acquired their breeding plumage earlier; however, in contrast to males, early molt did not seem to be costly since unfavorable environmental conditions or previous reproductive effort did not delay molt. Early female molt was not associated with any indicator of reproductive quality nor did it attract additional offspring care by their partners. We also found no association between early molt and the likelihood of acquiring a dominant (breeding) position or with the presence or proximity to same-sex rivals. Our study results, which are similar to previous findings in conspecific males, suggest that directional selection for early molt might be relaxed in this species, in contrast to other genetically polygamous fairy wrens in which early molt predicts extrapair mating success in males. However, the finding that molt timing is status dependent raises the possibility that other attributes of the ornament may fulfill an adaptive function in females.

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