scholarly journals Osteoprotegerin and its ligands for regulating the osteal resorption: experimental and clinical application aspects under estrogen deficiency conditions

2004 ◽  
Vol 53 (1) ◽  
pp. 107-110
Author(s):  
S. V. Yureneva
Keyword(s):  
Clinical Application ◽  
Estrogen Deficiency ◽  
Post Menopausal Osteoporosis ◽  
Post Menopausal ◽  
Menopausal Osteoporosis

Modem conceptions concerning the role of OPG-RANK-RANKL system in a local paracrinic mechanism of the regulation of osteoclastogenesis and osteal resorption processes are presented in this article. Here, results of the first clinical researches of prognostic signification of ORG determinations for estimating disruption manifestations in osteal metabolism under estrogen deficiency conditions as well as data on the OPG use as an anti-resorbable agent at the treatment of post-menopausal osteoporosis.

scholarly journals Role of Th-17 lymphocytes in estrogen deficiency mediated bone loss in post menopausal osteoporosis

2017 ◽  
Vol 3 (3) ◽  
pp. S38
Author(s):  
Shah Waliullah ◽  
Vineet Sharma ◽  
R.N. Srivastava ◽  
A.A. Mahdi ◽  
Yashodhara Pradeep ◽  
...  
Keyword(s):  
Bone Loss ◽  
Estrogen Deficiency ◽  
Post Menopausal Osteoporosis ◽  
Th 17 ◽  
Post Menopausal ◽  
Menopausal Osteoporosis

scholarly journals Estrogen withdrawal alters cytoskeletal and primary ciliary dynamics resulting in increased Hedgehog and osteoclastogenic paracrine signalling in osteocytes

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ivor P. Geoghegan ◽  
Laoise M. McNamara ◽  
David A. Hoey
Keyword(s):  
Focal Adhesions ◽  
Cell Area ◽  
Hedgehog Signalling ◽  
Paracrine Signalling ◽  
Post Menopausal Osteoporosis ◽  
Estrogen Withdrawal ◽  
Tightly Coupled ◽  
Post Menopausal ◽  
Menopausal Osteoporosis

AbstractEstrogen deficiency during post-menopausal osteoporosis leads to osteoclastogenesis and bone loss. Increased pro-osteoclastogenic signalling (RANKL/OPG) by osteocytes occurs following estrogen withdrawal (EW) and is associated with impaired focal adhesions (FAs) and a disrupted actin cytoskeleton. RANKL production is mediated by Hedgehog signalling in osteocytes, a signalling pathway associated with the primary cilium, and the ciliary structure is tightly coupled to the cytoskeleton. Therefore, the objective of this study was to investigate the role of the cilium and associated signalling in EW-mediated osteoclastogenic signalling in osteocytes. We report that EW leads to an elongation of the cilium and increase in Hedgehog and osteoclastogenic signalling. Significant trends were identified linking cilia elongation with reductions in cell area and % FA area/cell area, indicating that cilia elongation is associated with disruption of FAs and actin contractility. To verify this, we inhibited FA assembly via αvβ3 antagonism and inhibited actin contractility and demonstrated an elongated cilia and increased expression of Hh markers and Rankl expression. Therefore, our results suggest that the EW conditions associated with osteoporosis lead to a disorganisation of αvβ3 integrins and reduced actin contractility, which were associated with an elongation of the cilium, activation of the Hh pathway and osteoclastogenic paracrine signalling.

Role Of Weight-bearing Exercises In The Treatment Of Post-menopausal Osteoporosis

2018 ◽  
Vol 28 (2) ◽  
pp. 122-125 ◽  
Author(s):  
Shazia Rafiq ◽  
Sobia Zia ◽  
Muhammad Junaid Ijaz ◽  
Hassan Anjum Shahid ◽  
Muhammad Adeel
Keyword(s):  
Weight Bearing ◽  
Post Menopausal Osteoporosis ◽  
Post Menopausal ◽  
Menopausal Osteoporosis

Efficacy of Denosumab on bone metabolism after a 12-month treatment, in women with severe post-menopausal osteoporosis

2014 ◽  
Author(s):  
Renato Pastore ◽  
Patrizio Pasqualetti ◽  
Laura Chioma ◽  
Giuseppe Vancieri ◽  
Simona Frontoni
Keyword(s):  
Bone Metabolism ◽  
Post Menopausal Osteoporosis ◽  
Post Menopausal ◽  
Menopausal Osteoporosis

Medicinal Plants for the Management of Post Menopausal Osteoporosis: A Review~!2009-08-29~!2009-11-14~!2010-03-05~!

2010 ◽  
Vol 2 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Annie Shirwaikar ◽  
Saleemulla Khan ◽  
Yogesh H. Kamariya ◽  
Bharatkumar D. Patel ◽  
Falguni P. Gajera
Keyword(s):  
Medicinal Plants ◽  
Post Menopausal Osteoporosis ◽  
Post Menopausal ◽  
Menopausal Osteoporosis
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