Efficacy of Denosumab on bone metabolism after a 12-month treatment, in women with severe post-menopausal osteoporosis

2014 ◽  
Author(s):  
Renato Pastore ◽  
Patrizio Pasqualetti ◽  
Laura Chioma ◽  
Giuseppe Vancieri ◽  
Simona Frontoni
Keyword(s):  
Bone Metabolism ◽  
Post Menopausal Osteoporosis ◽  
Post Menopausal ◽  
Menopausal Osteoporosis

scholarly journals Expression of circulating Mir-139-5p is associated with Postmenopausal Osteoporosis in Indian women

2021 ◽  
Vol 10 (4) ◽  
pp. 102-105
Author(s):  
Rupakala BM ◽  
K Anbazhaganb ◽  
S Prabhakarac ◽  
MPA Sailakshmia
Keyword(s):  
Bone Metabolism ◽  
Therapeutic Strategies ◽  
Circulating Mirnas ◽  
Biochemical Tests ◽  
Indian Women ◽  
Post Menopausal Osteoporosis ◽  
Menopausal Women ◽  
Control Bone ◽  
Post Menopausal ◽  
Menopausal Osteoporosis

Background: Osteoporosis in post-menopausal women is known to progress periodically and is highly associated with inflammation. MicroRNAs regulate inflammatory process, which may therefore control bone metabolism. Deregulation of miRNAs associated with inflammation may lead to development and progression of osteoporosis. We selected four miRNAs known to be involved in inflammation to test their association with post-menopausal osteoporosis. Methods: We quantified four circulating miRNAs, hsa-miR-139-5p, hsa-miR-342-3p, hsa-miR-146a and hsa-miR-24-3p in plasma samples of 25 post-menopausal osteoporosis and 25 post-menopausal healthy subjects. Related biochemical tests were done using Cobas e411 and ELISA. Results: Upon quantification of circulating miRNAs, we observed that hsa-miR-139-5p was expressed higher in post-menopausal osteoporotic samples (p=0.01). The expression of hsa-miR-24-3p was seen lower in osteoporotic samples though not highly significant (p=0.2). Conclusion: Differential expression of hsa-miR-139-5p and hsa-miR-24-3p was seen in osteoporosis subjects. These miRNA could be significantly involved in development and progression of osteoporosis. Further studies are required to highlight miRNAs’ involvement in regulating bone metabolism, which could be manipulated to use them as marker or therapeutic strategies to alleviate osteoporosis.

Efficacy of PTH 1-84 on bone metabolism after 18-months treatment in women with severe post-menopausal osteoporosis

Bone ◽  
2010 ◽  
Vol 47 ◽  
pp. S214
Author(s):  
R. Pastore ◽  
D. Mentuccia ◽  
P. Borboni ◽  
A. Ventricini ◽  
A. Pavone ◽  
...  
Keyword(s):  
Bone Metabolism ◽  
Post Menopausal Osteoporosis ◽  
Post Menopausal ◽  
Menopausal Osteoporosis

Medicinal Plants for the Management of Post Menopausal Osteoporosis: A Review~!2009-08-29~!2009-11-14~!2010-03-05~!

2010 ◽  
Vol 2 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Annie Shirwaikar ◽  
Saleemulla Khan ◽  
Yogesh H. Kamariya ◽  
Bharatkumar D. Patel ◽  
Falguni P. Gajera
Keyword(s):  
Medicinal Plants ◽  
Post Menopausal Osteoporosis ◽  
Post Menopausal ◽  
Menopausal Osteoporosis

Efficacy of PTH 1-84 after 18-months treatment in women with severe post-menopausal osteoporosis

Bone ◽  
2010 ◽  
Vol 47 ◽  
pp. S87-S88
Author(s):  
R. Pastore ◽  
A. Ventricini ◽  
A. Pavone ◽  
P. Di Giacinto ◽  
P. Borboni ◽  
...  
Keyword(s):  
Post Menopausal Osteoporosis ◽  
Post Menopausal ◽  
Menopausal Osteoporosis
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