scholarly journals Features of the specific humoral response and cytokine regulation in whooping cough in children

2015 ◽  
Vol 20 (5) ◽  
pp. 42-48
Author(s):  
O. P Popova ◽  
T. S Skirda ◽  
I. M Fedorova ◽  
S. I Koteleva
Keyword(s):  
Comparative Analysis ◽  
Whooping Cough ◽  
Humoral Response ◽  
Medical Examination ◽  
Production Level ◽  
Cytokine Regulation ◽  
Early Stages ◽  
Vaccination History ◽  
Specific Humoral Response

In the article there is presented the comparative analysis of the character of the specific humoral response to pertussis in dependence on the age, terms of the disease and vaccination history in 279 patients, among which 114 patients were under 1 and 165 patients - over 1 year of the age. In the study of the level of the production of antibodies of different isotypes in unvaccinated patients of different age in dependence on the terms of medical examination it has been revealed that in the patients under the age of 1 year there was typical the low production of all the classes of antibodies in any time of the disease, especially IgM. It has been shown that in babies aged from 0 to 3 and from 4 to 6 months old the production level of these immunoglobulins in examination at the early stages of the disease was established to be considerably lower than in the patients at the age from 7 to 12 months, and was equal to 1,1 ± 0,4 and 1,5 ± 0,1 U/ml versus 9,1 ± 3,8 U/ml correspondingly, (p

Specific humoral response and effect on rectal temperature of two clostridial vaccines in lambs

2011 ◽  
Vol 168 (17) ◽  
pp. 458-458 ◽  
Author(s):  
M. Cervino ◽  
L. Figueras ◽  
S. Martin ◽  
L. Elvira ◽  
M. Callus ◽  
...  
Keyword(s):  
Rectal Temperature ◽  
Humoral Response ◽  
Specific Humoral Response

scholarly journals Comparative Analysis of the Independent Medical Examination Reports and Legal Decisions in Pain Medicine

2010 ◽  
Vol 23 (1) ◽  
pp. 28 ◽  
Author(s):  
Francis Sahngun Nahm ◽  
Pyung Bok Lee ◽  
Tae Hun Kim ◽  
Yong Chul Kim ◽  
Chul Joong Lee
Keyword(s):  
Comparative Analysis ◽  
Medical Examination ◽  
Pain Medicine ◽  
Legal Decisions ◽  
Independent Medical Examination

scholarly journals Pertussis in a child of the first month of life from family contact

2021 ◽  
Vol 13 (2) ◽  
pp. 149-153
Author(s):  
O. V. Iozefovich ◽  
S. M. Kharit ◽  
E. I. Bobova ◽  
E. A. Budnikova
Keyword(s):  
Young Children ◽  
Pregnant Women ◽  
Clinical Observation ◽  
Whooping Cough ◽  
Pertussis Infection ◽  
Early Stages ◽  
Parents And Children ◽  
The Family ◽  
The Face ◽  
Family Contact

A case of whooping cough in a moderate form in a child of the first month of life is described in the presented clinical observation. The moderate form was manifested by the duration of the preconvulsive period up to 5 days, the appearance of cyanosis of the face when coughing in the early stages of the disease (1 week), an increase in the number of coughing attacks. The difficulties of treating pertussis in young children are demonstrated by our observation of the course of the disease. There is no vaccination against pertussis in children in the family due to the refusal of parents and children with prolonged coughing were not examined at the outpatient stage. As a result, chemoprophylaxis was not performed on time and the newborn was discharged from the hospital to the center of pertussis infection. The solution to the problem of reducing the incidence in children in the first months of life should be vaccination of pregnant women in the last stages, and vaccination of the environment, including agerelated revaccinations. 

scholarly journals Assessment of the timeliness of vaccination against pertussis in children of the first year of life and the reasons for the violation of the vaccination schedule

2021 ◽  
Vol 13 (2) ◽  
pp. 79-86
Author(s):  
T. M. Chernova ◽  
V. N. Timchenko ◽  
A. I. Pedash ◽  
M. D. Subbotina ◽  
O. I. Bulina ◽  
...  
Keyword(s):  
Young Children ◽  
Whooping Cough ◽  
Vaccination Schedule ◽  
Severe Form ◽  
Recombinant Interferon ◽  
Post Vaccination ◽  
Ifn Alpha ◽  
Vaccination History ◽  
Acute Respiratory Viral Infection ◽  
Vaccination Period

The maximum incidence of pertussis in young children confirms the importance of their timely immunization.The goal is – to study the timeliness of vaccination against whooping cough, causes of violation of the vaccination schedule in young children, the effect of recombinant interferon-a on the post-vaccination period.Materials and methods: the vaccination history and data on the course of the post-vaccination period after immunization with DPT and DaPT vaccines of 469 children at the age of 3–24 months were studied.Results. The analysis showed that 14,9% of the observed children were not vaccinated against whooping cough in a timely manner. Of these: 34,3% had a written refusal to vaccinate (5.1% of the total number of observed children), in 32,8% of cases, the vaccination schedule was violated due to late arrival of parents, 32,9% of children by the start of immunization had medical challenges, and only half of them had justified contraindications. Non-serious side effects associated with immunization were observed in 11.3% of cases, statistically more often with DTP (22,0%) compared with DaPT (5.,5%). General and local reactions, in general, were recorded on DPT (6,9% and 15,1%, respectively) and less often developed with the use of DaPT (1,0% and 4,5%, respectively). Within 1 month after immunization, 16,2% of the observed children had an acute respiratory viral infection of varying severity. Those who did not receive antiviral therapy more often carried the disease in a moderate and severe form, which in all cases led to the postponement of the administration of the second and third doses of the vaccine.Conclusion. To increase the timeliness of vaccination of children against whooping cough, medical professionals should persistently remind parents about the timing of turnout for the next vaccination, when making medical withdrawals, be guided by modern methodological documents and instructions for vaccines. The use of antiviral and immunomodulatory effects of IFN-alpha drugs allows us to comply with the recommended schedule for vaccination of children with a high risk of SARS in the post-vaccination period.

scholarly journals Specific humoral response in cancer patients treated with a VEGF-specific active immunotherapy procedure within a compassionate use program

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Javier Sánchez Ramírez ◽  
◽  
Yanelys Morera Díaz ◽  
Mónica Bequet-Romero ◽  
Francisco Hernández-Bernal ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Humoral Response ◽  
Active Immunotherapy ◽  
Compassionate Use ◽  
Specific Active Immunotherapy ◽  
Specific Humoral Response

scholarly journals The expression of an intraspecific aggressive reaction in the face of a stressor agent alters the immune response in rats

2005 ◽  
Vol 65 (2) ◽  
pp. 203-209 ◽  
Author(s):  
J. M. Barreto-Medeiros ◽  
E. G. Feitoza ◽  
K. Magalhães ◽  
R. R. da Silva ◽  
F. M. Manhães-de-Castro ◽  
...  
Keyword(s):  
Immune Response ◽  
Immune System ◽  
Humoral Response ◽  
Aggressive Response ◽  
Control Group ◽  
Blood Samples ◽  
Humoral Immune ◽  
The Face ◽  
Intraspecific Aggressiveness ◽  
Specific Humoral Response

The repercussion on the immune response of the expression of intraspecific aggressiveness in the face of a stressor agent was investigated in rats. Ninety-day-old animals were divided into three groups: the control group (only immunological measurements were performed), the foot-shock (FS) (animals individually receiving FS), and the intraspecific aggressive response (IAR) group (animals receiving FS and presenting IAR). For immunological measurements, blood samples were collected promptly at 7 and 15 days after FS or IAR. The FS reduced the total leukocyte amount presented. However, aggressiveness triggered not only reduction of the leukocytes, but also lymphocyte decrease and neutrophil increase. Moreover, an elevation in total leukocytes associated with an increase in the humoral immune response was also observed one week after IAR. In this study, the expression of intraspecific aggressiveness in the face of a stressor seemed to activate the immune system and to potentiate the antigen specific humoral response.

scholarly journals Specific humoral response of hosts with variable schistosomiasis susceptibility

2015 ◽  
Vol 94 (1) ◽  
pp. 52-65 ◽  
Author(s):  
Patrick Driguez ◽  
Hamish EG McWilliam ◽  
Soraya Gaze ◽  
David Piedrafita ◽  
Mark S Pearson ◽  
...  
Keyword(s):  
Humoral Response ◽  
Specific Humoral Response
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