scholarly journals CLINICAL AND LABORATORY FEATURES OF ENTEROVIRAL MENINGITIS IN CHILDREN UNDER MODERN CONDITIONS, (ACCORDING TO THE DATA OF YAROSLAVL REGION)

2012 ◽  
Vol 17 (3) ◽  
pp. 38-42
Author(s):  
S. N. Eshmolov ◽  
I. G. Sitnikov ◽  
I. M. Melnikov
Keyword(s):  
Nervous System ◽  
Protective Role ◽  
Treatment Programs ◽  
Basic Therapy ◽  
Enteroviral Infection ◽  
Laboratory Features ◽  
Enteroviral Meningitis ◽  
Meningitis In Children ◽  
Discharge From Hospital

152 cases of enteroviral meningitis in children aged 3 to 17years treated at the Infectious Diseases Hospital in Yaroslavl have been analyzed. The dominance of moderate forms of the disease with hypertension-hydrocephalic syndrome has been established. The combination with other clinical forms of enteroviral infection was rare, except for reactive pancreatitis. In patients with aseptic meningitis in the acute phase of illness an imbalance of cytokine profile due to increasing the production ofproinflammatory and reduction of the protective role of anti-inflammatory cytokines took place. Despite the relatively favorable course, a high risk of developing functional and organic disorders of the nervous system in a period of convalescence maintained, which creates conditions for the revision and supplement the standard protocols of treatment programs by including in them medicines of etiotropic targeting. The authors have developed regimens and performed the analysis of clinical and immunological efficacy of drugs with antiviral and interferonogenic action - arbidol and amiksin - in the content of complex basic therapy. In addition, the results of outpatient monitoring ofconvalescents 3 months after discharge from hospital have been analyzed. These data justify the need and desirability of inclusion of etiotropic drugs in standards of the basic therapy of enteroviral meningitis in children.

scholarly journals Activation and Role of Astrocytes in Ischemic Stroke

2021 ◽  
Vol 15 ◽  
Author(s):  
Xin-Ya Shen ◽  
Zhen-Kun Gao ◽  
Yu Han ◽  
Mei Yuan ◽  
Yi-Sha Guo ◽  
...  
Keyword(s):  
Nervous System ◽  
Ischemic Stroke ◽  
Protective Role ◽  
Reactive Astrocytes ◽  
High Morbidity ◽  
Temporal Expression ◽  
The Central Nervous System ◽  
Controversial Topic ◽  
And Function

Ischemic stroke refers to the disorder of blood supply of local brain tissue caused by various reasons. It has high morbidity and mortality worldwide. Astrocytes are the most abundant glial cells in the central nervous system (CNS). They are responsible for the homeostasis, nutrition, and protection of the CNS and play an essential role in many nervous system diseases’ physiological and pathological processes. After stroke injury, astrocytes are activated and play a protective role through the heterogeneous and gradual changes of their gene expression, morphology, proliferation, and function, that is, reactive astrocytes. However, the position of reactive astrocytes has always been a controversial topic. Many studies have shown that reactive astrocytes are a double-edged sword with both beneficial and harmful effects. It is worth noting that their different spatial and temporal expression determines astrocytes’ various functions. Here, we comprehensively review the different roles and mechanisms of astrocytes after ischemic stroke. In addition, the intracellular mechanism of astrocyte activation has also been involved. More importantly, due to the complex cascade reaction and action mechanism after ischemic stroke, the role of astrocytes is still difficult to define. Still, there is no doubt that astrocytes are one of the critical factors mediating the deterioration or improvement of ischemic stroke.

scholarly journals The evolution of clinical and laboratory features enteroviral meningitis in children

2019 ◽  
Vol 18 (4) ◽  
pp. 43-48
Author(s):  
S. P. Kokoreva ◽  
N. V. Kazartseva ◽  
V. B. Kotlova
Keyword(s):  
Incidence Rate ◽  
Russian Federation ◽  
Enterovirus Infection ◽  
Clinical Form ◽  
Evolutionary Changes ◽  
Laboratory Features ◽  
The Russian Federation ◽  
Enteroviral Meningitis ◽  
Meningitis In Children

In recent years, enterovirus infection (EVI) retains its cyclical nature with an increase in the incidence rate in the Russian Federation in 2000, 2006, 2009, 2013 and 2017. Observation of 41 patients with laboratory-confirmed enteroviral meningitis (EVM) in 2000, 54 children in 2013, and 56 patients in 2018 revealed the clinical and laboratory features of this clinical form of the disease, mainly concerning changes in hemo- and liquorogram parameters, which allowed to trace the evolutionary changes during this infection in children.

Glial-mediated neuroprotection: Evidence for the protective role of the NO-cGMP pathway via neuron-glial communication in the peripheral nervous system

Glia ◽  
2004 ◽  
Vol 49 (2) ◽  
pp. 197-210 ◽  
Author(s):  
Thimmasettappa Thippeswamy ◽  
Jennifer S. Mckay ◽  
Richard Morris ◽  
John Quinn ◽  
Liang-Fong Wong ◽  
...  
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System ◽  
Protective Role ◽  
Cgmp Pathway

ISDN2012_0292: Protective role of docosahexaenoic acid on aluminum induced neurochemical and neurobehavioral changes in rat central nervous system

2012 ◽  
Vol 30 (8) ◽  
pp. 691-692
Author(s):  
Manisha Chaudhary ◽  
Devesh Kumar Joshi ◽  
Mantosh Kumar Satapathy ◽  
Sandeep Kumar ◽  
Sandeep Tripathi
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Docosahexaenoic Acid ◽  
Protective Role

scholarly journals The Protective Effect of Omega 3 and Vitamin D in Preventing Damage Occurring in Central Nervous System of Neonatal Rats Exposed to Cigarette Smoke in Intrauterine Period

2021 ◽  
Vol 8 (2) ◽  
pp. 1-6
Author(s):  
Hayri Gözlükgiller ◽  
Keyword(s):  
Central Nervous System ◽  
Vitamin D ◽  
Nervous System ◽  
Cigarette Smoke ◽  
Protective Role ◽  
Toxic Effects ◽  
Cigarette Smoke Exposure ◽  
Neonatal Rats ◽  
Omega 3

In our study, the toxic effects of cigarette smoke exposure on central nervous system and the protective role of Omega 3 and Vitamin D against these toxic effects were investigated at biochemical and histological level.

Clinical and epidemiological features and residual manifestations of serous enteroviralmeningitis in children in North Ossetia-Alania

2016 ◽  
Vol 21 (32) ◽  
pp. 46-51
Author(s):  
Калоева ◽  
Zinaida Kaloeva ◽  
Гуссоева ◽  
I. Gussoeva ◽  
Албегова ◽  
...  
Keyword(s):  
Early Period ◽  
Immune Dysfunction ◽  
School Age ◽  
Epidemiological Features ◽  
Laboratory Features ◽  
The Central Nervous System ◽  
Typical Summer ◽  
Enteroviral Meningitis ◽  
Meningitis In Children ◽  
North Ossetia

The article presents the analysis of the epidemiological, clinical and laboratory features of serous meningitis enteroviral etiology in children hospitalized at the RCCH of Vladikavkaz in 2008–2012. We have also studied the residual manifestations of enteroviral meningitis in 44 patients in the early period of convalescence. The study showed that of RNO-Alania typical summer – autumn seasonality of serous meningitis enteroviral etiology in children. The central nervous system caused by enteroviruses more often develops in children of preschool and school age. The clinical picture of enteroviral meningitis remains a leading hypertension – hydrocephalic syndrome. In the early period of convalescence enteroviral meningitis in children often formed cerebro-asthenic, hypertension, neurosis-like syndromes and syndrome immune dysfunction.

scholarly journals MECHANISMS OF DAMAGE TO THE NERVOUS SYSTEM IN A REPERFUSION SYNDROME AND ITS CORRECTION

2021 ◽  
Vol 10 (4) ◽  
pp. 50-57
Author(s):  
V. Z. Kharchenko ◽  
R. A. Mnevets ◽  
A. A. Beketov
Keyword(s):  
Nervous System ◽  
Protective Role ◽  
Pathogenetic Therapy

This article describes protective role of the combined injection of the «Gordox» (Hungary) 10000 ATU/kg and «Cerebrolysin» (Austria) 0,7 ml/kg in a pathogenetic therapy of nervous system damage during reperfusion syndrome. It is determined that preventive usage of that kind combination before revascularization of the ischemic tissues leads to proteolysis activation prevention in a brain, prevents structural violations and leads to main functions of the nervous system saving.

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