scholarly journals SCIENTIFIC AND THEORETICAL VALIDATION OF DEVELOPMENT OF PERSONALIZED ANTI-CANCER CELL PREPARATION ONTHE BASES OF CLINICAL ONCOPROTEOMICS TECHNOLOGY

2014 ◽  
Vol 5 (1) ◽  
pp. 44-60
Author(s):  
I S Bryukhovetskiy ◽  
A S Bryukhovetskiy
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Information Structure ◽  
Malignant Tumors ◽  
Tumor Therapy ◽  
Malignant Neoplasms ◽  
Alternative Approach ◽  
Anti Cancer ◽  
Main Target ◽  
A Cell

In the article the authors present analysis of current conventional methodological and technological approaches to contemporary therapy of cancer and certain malignant neoplasms. Based upon the revision of available concepts of clinical oncology, the scientific and theoretical validation of novel approaches to the development of innovative technologies of proteomebased regulatory tumor therapy was attempted. The authors defined their original viewpoint on the development of the preparations for personalized therapy of cancer and proposed a new methodology and alternative approach to the malignant tumors therapy when a cancer stem cell becomes the main target of anticancer therapy. The authors showed that proteome of a cancer stem cell is the most stable information structure of a cell and can be perceived as the main therapeutic target.

The cancer stem cell microenvironment and anti-cancer therapy

2009 ◽  
Vol 85 (11) ◽  
pp. 955-962 ◽  
Author(s):  
Veerander P. S. Ghotra ◽  
Jordi C. Puigvert ◽  
Erik H. J. Danen
Keyword(s):  
Stem Cell ◽  
Cancer Therapy ◽  
Cancer Stem Cell ◽  
Cell Microenvironment ◽  
Anti Cancer

The palladacycle, AJ-5, exhibits anti-tumour and anti-cancer stem cell activity in breast cancer cells

2015 ◽  
Vol 357 (1) ◽  
pp. 206-218 ◽  
Author(s):  
Saeb Aliwaini ◽  
Jade Peres ◽  
Wendy L. Kröger ◽  
Angelique Blanckenberg ◽  
Jo de la Mare ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Cell Activity ◽  
Anti Cancer ◽  
Stem Cell Activity

scholarly journals Repositioning CEP-1347, a chemical agent originally developed for the treatment of Parkinson’s disease, as an anti-cancer stem cell drug

Oncotarget ◽  
2017 ◽  
Vol 8 (55) ◽  
pp. 94872-94882 ◽  
Author(s):  
Masashi Okada ◽  
Hiroyuki Takeda ◽  
Hirotsugu Sakaki ◽  
Kenta Kuramoto ◽  
Shuhei Suzuki ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Chemical Agent ◽  
Anti Cancer

scholarly journals Tumorsphere as an effective in vitro platform for screening anti-cancer stem cell drugs

Oncotarget ◽  
2015 ◽  
Vol 7 (2) ◽  
pp. 1215-1226 ◽  
Author(s):  
Che-Hsin Lee ◽  
Cheng-Chia Yu ◽  
Bing-Yen Wang ◽  
Wen-Wei Chang
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Anti Cancer

scholarly journals Genes Involved in the Transcriptional Regulation of Pluripotency Are Expressed in Malignant Tumors of the Uterine Cervix and Can Induce Tumorigenic Capacity in a Nontumorigenic Cell Line

2019 ◽  
Vol 2019 ◽  
pp. 1-14
Author(s):  
Graciela Ruiz ◽  
Heriberto A. Valencia-González ◽  
Delia Pérez-Montiel ◽  
Felipe Muñoz ◽  
Rodolfo Ocadiz-Delgado ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Stem Cell ◽  
Transcription Factors ◽  
Cancer Stem Cell ◽  
Cell Line ◽  
Target Genes ◽  
Malignant Tumors ◽  
Expression Profiles ◽  
Ectopic Expression ◽  
Normal Tissues

Transcription factors OCT4, SOX2, KLF4, C-MYC, and NANOG (OSKM-N) regulate pluripotency and stemness, and their ectopic expression reprograms human and murine fibroblasts that constitute the key of regenerative medicine. To determine their contribution to cell transformation, we analyzed the gene expression profiles of these transcription factors in cervical cancer samples and found that they are preferentially expressed in the tumor component. Also, cancer stem cell-enriched cultures grown as sphere cultures showed overexpression of OSKM-N genes. Importantly, we observed that lentiviral-mediated transduction of these factors confers, to a nontumorigenic immortalized human cell line, properties of cancer stem cells as the ability to form tumors in a mouse model. When we performed a meta-analysis using microarray data from cervical cancer biopsies and normal tissues, we found that the expression of OSKM-N and some target genes allowed separating tumor and normal tissues between samples, which enhanced the importance of OSKM-N in the tumorigenesis. Finally, we analyzed and compared both transcript and protein expression profiles of these factors within a cohort of patients with cervical cancer. To our knowledge, this is the first time that the expression of OSKM-N is described to induce one of the main characteristics of the cancer stem cell, the tumorigenicity. And, more importantly, its exogenous expression in a nontumorigenic cell line is sufficient to induce a tumorigenic phenotype; furthermore, the differential expression of this transcription factor distinguishes tumor tissue and normal tissue in cervical samples.

scholarly journals Assessment of potential anti-cancer stem cell activity of marine algal compounds using an in vitro mammosphere assay

2013 ◽  
Vol 13 (1) ◽  
pp. 39 ◽  
Author(s):  
Jo-Anne de la Mare ◽  
Jason N Sterrenberg ◽  
Mugdha G Sukhthankar ◽  
Maynard T Chiwakata ◽  
Denzil R Beukes ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cell Activity ◽  
Anti Cancer ◽  
Stem Cell Activity ◽  
Marine Algal ◽  
Mammosphere Assay

scholarly journals Anti-cancer stem cell activity of a sesquiterpene lactone isolated from Ambrosia arborescens and of a synthetic derivative

PLoS ONE ◽  
2017 ◽  
Vol 12 (9) ◽  
pp. e0184304 ◽  
Author(s):  
Wendy Soria Sotillo ◽  
Rodrigo Villagomez ◽  
Sandra Smiljanic ◽  
Xiaoli Huang ◽  
Atena Malakpour ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Sesquiterpene Lactone ◽  
Cell Activity ◽  
Anti Cancer ◽  
Stem Cell Activity ◽  
Synthetic Derivative

scholarly journals Lipophilic Modification of an Anti‐Cancer Stem Cell Agent Improves Pharmacokinetic and Anti‐Cancer Properties

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Shravan Morla ◽  
Daniel K. Afosah ◽  
Connor O'Hara ◽  
Rio Boothello ◽  
Bhaumik B. Patel ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Anti Cancer

A phase 1b study of the anti-cancer stem cell agent demcizumab (DEM), pemetrexed (PEM) & carboplatin (CARBO) in pts with 1st line non-squamous NSCLC.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. 8045-8045 ◽  
Author(s):  
Dusan Kotasek ◽  
Brett Gordon Maxwell Hughes ◽  
Ben Markman ◽  
Michael Millward ◽  
Esther Holgado ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Anti Cancer ◽  
Phase 1B
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