scholarly journals Tumorsphere as an effective in vitro platform for screening anti-cancer stem cell drugs

Oncotarget ◽  
2015 ◽  
Vol 7 (2) ◽  
pp. 1215-1226 ◽  
Author(s):  
Che-Hsin Lee ◽  
Cheng-Chia Yu ◽  
Bing-Yen Wang ◽  
Wen-Wei Chang
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Anti Cancer

scholarly journals Assessment of potential anti-cancer stem cell activity of marine algal compounds using an in vitro mammosphere assay

2013 ◽  
Vol 13 (1) ◽  
pp. 39 ◽  
Author(s):  
Jo-Anne de la Mare ◽  
Jason N Sterrenberg ◽  
Mugdha G Sukhthankar ◽  
Maynard T Chiwakata ◽  
Denzil R Beukes ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cell Activity ◽  
Anti Cancer ◽  
Stem Cell Activity ◽  
Marine Algal ◽  
Mammosphere Assay

scholarly journals Isolation and Establishment of a Highly Proliferative, Cancer Stem Cell-Like, and Naturally Immortalized Triple-Negative Breast Cancer Cell Line, KAIMRC2

Cells ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1303
Author(s):  
Rizwan Ali ◽  
Hajar Al Zahrani ◽  
Tlili Barhoumi ◽  
Alshaimaa Alhallaj ◽  
Abdullah Mashhour ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cell Line ◽  
Cancer Cell ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cell Line ◽  
Triple Negative ◽  
Cancer Cell Line

In vitro studies of a disease are key to any in vivo investigation in understanding the disease and developing new therapy regimens. Immortalized cancer cell lines are the best and easiest model for studying cancer in vitro. Here, we report the establishment of a naturally immortalized highly tumorigenic and triple-negative breast cancer cell line, KAIMRC2. This cell line is derived from a Saudi Arabian female breast cancer patient with invasive ductal carcinoma. Immunocytochemistry showed a significant ratio of the KAIMRC2 cells’ expressing key breast epithelial and cancer stem cells (CSCs) markers, including CD47, CD133, CD49f, CD44, and ALDH-1A1. Gene and protein expression analysis showed overexpression of ABC transporter and AKT-PI3Kinase as well as JAK/STAT signaling pathways. In contrast, the absence of the tumor suppressor genes p53 and p73 may explain their high proliferative index. The mice model also confirmed the tumorigenic potential of the KAIMRC2 cell line, and drug tolerance studies revealed few very potent candidates. Our results confirmed an aggressive phenotype with metastatic potential and cancer stem cell-like characteristics of the KAIMR2 cell line. Furthermore, we have also presented potent small molecule inhibitors, especially Ryuvidine, that can be further developed, alone or in synergy with other potent inhibitors, to target multiple cancer-related pathways.

scholarly journals Forced expression of Nanog with mRNA synthesized in vitro to evaluate the malignancy of HeLa cells through acquiring cancer stem cell phenotypes

2016 ◽  
Vol 35 (5) ◽  
pp. 2643-2650 ◽  
Author(s):  
YAN DING ◽  
AI QING YU ◽  
XIAO LI WANG ◽  
XING RONG GUO ◽  
YA HONG YUAN ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Hela Cells ◽  
Cell Phenotypes

The cancer stem cell microenvironment and anti-cancer therapy

2009 ◽  
Vol 85 (11) ◽  
pp. 955-962 ◽  
Author(s):  
Veerander P. S. Ghotra ◽  
Jordi C. Puigvert ◽  
Erik H. J. Danen
Keyword(s):  
Stem Cell ◽  
Cancer Therapy ◽  
Cancer Stem Cell ◽  
Cell Microenvironment ◽  
Anti Cancer

The palladacycle, AJ-5, exhibits anti-tumour and anti-cancer stem cell activity in breast cancer cells

2015 ◽  
Vol 357 (1) ◽  
pp. 206-218 ◽  
Author(s):  
Saeb Aliwaini ◽  
Jade Peres ◽  
Wendy L. Kröger ◽  
Angelique Blanckenberg ◽  
Jo de la Mare ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Cell Activity ◽  
Anti Cancer ◽  
Stem Cell Activity

scholarly journals Repositioning CEP-1347, a chemical agent originally developed for the treatment of Parkinson’s disease, as an anti-cancer stem cell drug

Oncotarget ◽  
2017 ◽  
Vol 8 (55) ◽  
pp. 94872-94882 ◽  
Author(s):  
Masashi Okada ◽  
Hiroyuki Takeda ◽  
Hirotsugu Sakaki ◽  
Kenta Kuramoto ◽  
Shuhei Suzuki ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Chemical Agent ◽  
Anti Cancer

658 CD44, Pancreatic Cancer Stem Cell Marker, Positive Cells Are Responsible for the Acquiring Gemcitabine Induced Chemoresistance In Vitro

2008 ◽  
Vol 134 (4) ◽  
pp. A-96
Author(s):  
Sung Pil Hong ◽  
Jeong Youp Park ◽  
Jing Wen ◽  
Jin Wook Yoon ◽  
Kyung Hwa Park ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Stem Cell Marker ◽  
Cancer Stem Cell Marker ◽  
Cell Marker
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