scholarly journals Features of case management with neuromuscular disease during Covid-19. Clinical impression.

2020 ◽  
Author(s):  
Olga Karpova
Keyword(s):  
Risk Factors ◽  
Case Management ◽  
Clinical Picture ◽  
Neuromuscular Disease ◽  
Neuromuscular Transmission ◽  
Clinical Impression ◽  
Cytokine Storm ◽  
Pathogenetic Mechanism ◽  
Coronavirus Infection ◽  
Immunopathological Process

The new COVID-19 coronavirus infection, which has become a pandemic, is a very dangerous disease, the clinical picture of which can vary from mild to extremely severe forms of the course. Currently, there is no complete data on the pathogenetic mechanism of SARS-CoV-2 virulence, but there is probable data on risk factors for the development of extremely severe forms of COVID-19. The study of such factors becomes most suitable in terms of preventing the development and influence on the course of the disease in immunocompromised individuals and patients with impaired neuromuscular transmission. The article describes two clinical cases of extremely severe COVID-19 in patients with impaired neuromuscular transmission. Based on the analysis of the course of diseases, conclusions are made about the possible aggravation and mutual activation of the immunopathological process with the launch of the cascade mechanism of the "cytokine storm". An assumption has been made about the influence of HLA on the severity of COVID-19, which is confirmed by positive dynamics against the background of the introduction of IVIG, GCS, virusinactivated plasma, and extracorporeal detoxification methods.

Covid-19: features of the pathogenesis of the disease and targets for immunotherapeutic effects

2020 ◽  
Vol 20 (3) ◽  
pp. 75-88
Author(s):  
N. A. Klimov ◽  
A. S. Simbirtsev
Keyword(s):  
Life Cycle ◽  
Immune System ◽  
Clinical Picture ◽  
Scientific Literature ◽  
Renin Angiotensin System ◽  
Cytokine Storm ◽  
Laboratory Mice ◽  
Angiotensin System ◽  
Coronavirus Infection ◽  
The Complement System

An analysis of current scientific literature on the pathogenesis of the coronavirus infection that caused the 2019 pandemic, COVID-19, was carried out. The structure, genome, introduction into the cell and the life cycle of the SARS-CoV-2 virus that caused the pandemic, the mechanisms of protection of the virus from the hosts immune system, features of the clinical picture of coronavirus infection, the pathogenesis of viral pneumonia, in particular, disruption of the renin-angiotensin system, cytokine storm, participation of the complement system in the pathogenesis of COVID-19 are reviewed. The models of infections caused by SARS-CoV and SARS-CoV-2 in laboratory mice are also considered.

scholarly journals Clinical manifestations of new coronavirus infection (COVID-19) in children admitted to hospital

2021 ◽  
Vol 66 (5) ◽  
pp. 88-96
Author(s):  
D. I. Sadykova ◽  
S. V. Khaliullina ◽  
V. A. Anokhin ◽  
A. I. Ziatdinov ◽  
S. A. Senek ◽  
...  
Keyword(s):  
Risk Factors ◽  
Viral Infection ◽  
Clinical Picture ◽  
Clinical Manifestations ◽  
Infection Risk ◽  
Hospitalized Children ◽  
Respiratory Viral Infection ◽  
Laboratory Features ◽  
Infection Risk Factors ◽  
Coronavirus Infection

Objective. To describe clinical and laboratory features of COVID-19 in children admitted to the hospital.Children characteristics and research methods. The authors carried out a retrospective observational study, which included 204 children admitted to the Kazan hospital with a diagnosis of “new coronavirus infection” in the period from May 1 to October 30, 2020.Results. It was revealed that all hospitalized children had RNA of the SARS-CoV-2 virus (100%) in a smear from the nasopharynx and oropharynx detected by PCR and only 50% of patients were diagnosed with lung tissue lesions by computed tomography. The clinical picture of COVID-19 in children most often corresponds to the classic manifestations of a respiratory viral infection. Risk factors for the development of severe forms, described in adults, were recorded only in isolated cases in our study.Conclusion. The clinical picture of COVID-19 in children most often corresponds to the classic manifestations of a respiratory viral infection. Risk factors for the development of severe forms, described in adults, were recorded in isolated cases in our study.

scholarly journals Naringenin as a Possible Candidate Against SARS-CoV-2 Infection and in the Pathogenesis of COVID-19

2021 ◽  
Vol 16 (12) ◽  
pp. 1934578X2110667
Author(s):  
Pawan K. Agrawal ◽  
Chandan Agrawal ◽  
Gerald Blunden
Keyword(s):  
Risk Factors ◽  
Fruits And Vegetables ◽  
Therapeutic Targets ◽  
Computational Studies ◽  
Cytokine Storm ◽  
Host Interactions ◽  
Coronavirus Infection ◽  
Anti Inflammatory ◽  
Associated Risk Factors

Naringenin, widely distributed in fruits and vegetables, is endowed with antiviral and other health beneficial activities, such as immune-stimulating and anti-inflammatory actions that could play a role in contributing, to some extent, to either preventing or alleviating coronavirus infection. Several computational studies have identified naringenin as one of the prominent flavonoids that can possibly inhibit internalization of the virus, virus-host interactions that trigger the cytokine storm, and replication of the virus. This review highlights the antiviral potential of naringenin in COVID-19 associated risk factors and its predicted therapeutic targets against SARS-CoV-2 infection.

Clinical case of a comorbid patient with arterial hypertension

2020 ◽  
pp. 31-39
Author(s):  
Ella Polozova ◽  
Vsevolod Skvortsov ◽  
Olga Radaykina ◽  
Mariya Narvatkina ◽  
Anastasiya Seskina ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Risk Factors ◽  
Arterial Hypertension ◽  
Clinical Picture ◽  
Clinical Case ◽  
Diagnosis And Treatment ◽  
The Moment

The widespread prevalence of comorbid pathology determines the relevance of this problem. Comorbid pathology due to the interaction of diseases, drug pathomorphism, age characteristics of the patient, significantly changes clinical picture and course of the main nosology, affects severity of complications and their nature, significantly affects quality of life and prognosis of patients. Diagnosis and treatment of many diseases is complicated in the conditions of comorbidity. The article presents a clinical case of a comorbid patient with arterial hypertension from the moment of exposure to risk factors and ending with the formation of many concomitant diseases, as an example of trans-nosological comorbidity.

Features of the course of coronavirus infection in patients with diabetes mellitus

2022 ◽  
pp. 18-21
Author(s):  
Vladimir Anatolievich Klimov ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Human Population ◽  
Fatal Outcome ◽  
Significant Risk ◽  
Adverse Outcomes ◽  
Concomitant Disease ◽  
Patients With Diabetes ◽  
Coronavirus Infection ◽  
Population Mortality

Diabetesmellitus, overweight and the age of a patient over 65 years old are identified by clinicians as themain factors that can complicate the course of the coronavirus infection and increase the likelihood of fatal outcome. Although in the general human population mortality from coronavirus fluctuateswithin 3–5 %, sometimes very significantly differing in individual countries, this level can reach 15–25 % among patientswith diabetes, especially for those receiving insulin therapy. Diabetes mellitus as a concomitant disease in COVID-19 is considered one of the most significant risk factors for the development of adverse outcomes due to a more severe course of infection in conditions of hyperglycemia and other aggravating factors.

High cytokine levels and cytokine storm in the novel coronavirus infection

2021 ◽  
pp. 38-47
Author(s):  
Maksim Leonidovich Maksimov ◽  
Albina Ayratovna Zvegintseva ◽  
Lyudmila Yurievna Kulagina ◽  
Albina Zainutdinovna Nigmedzyanova ◽  
Elvina Ramisovna Kadyseva
Keyword(s):  
Peripheral Blood ◽  
High Frequency ◽  
The Novel ◽  
Cytokine Storm ◽  
The Public ◽  
Systemic Inflammatory Reaction ◽  
Scientific World ◽  
Cytokine Levels ◽  
Coronavirus Infection ◽  
Novel Coronavirus

A review article is based on current foreign sources. The level of cytokines in the peripheral blood can be increased in many diseases, but in some cases there may be an excess of their normal concentration in tens, hundreds or more times with the development of a peculiar clinical picture, which is based on a systemic inflammatory reaction. In the literature this condition has received the figurative name «cytokine storm», which highlights an extremely violent reaction of the immune system with an unknown (often unfavorable) outcome. Close attention of the scientific world and the public to the problem of extremely high levels of cytokines in the peripheral blood (hypercytokinemia) was drawn due to the high frequency of the cytokine storm in the novel coronavirus infection.

scholarly journals Influence of sexually transmitted infections in a horse breeding

2015 ◽  
Vol 69 (5-6) ◽  
pp. 443-452
Author(s):  
Marjan Kosec ◽  
Natasa Sterbenc ◽  
Janko Mrkun ◽  
Igor Klobucar ◽  
Primoz Klinc
Keyword(s):  
Risk Factors ◽  
Sexually Transmitted Diseases ◽  
Artificial Insemination ◽  
Clinical Picture ◽  
Preventive Measures ◽  
Sexually Transmitted ◽  
Direct Damage ◽  
Horse Breeding ◽  
Common Causes ◽  
Infectious Etiology

The most frequent problems in horses reproduction are generally divided into those of infectious and non infectious etiology. Common causes of infectious diseases are usual?ly viruses and bacteria, and less frequently protozoa, mykoplasma and fungi. In this work there are presented the most important fact about sexually transmitted diseases, their clinical picture, risk factors, preventive measures as well as measures to prevent and eradicate the diseases. The biggest risk factor for sexually transmitted diseases in horses are breeding stallions, both in natural mating and in artificial insemination. Therefore, in order to prevent genital infections in horses, it is essential that the stallions used for breeding are healthy (non-infected). That can be determined with certainty only if the stallions are examined (tested) just before the breeding season on most frequent sexually transmitted diseases (CEM,EAV). It is well known that in most cases the clinical picture of sexually transmitted diseses is not manifested on genitals. As well, variations in clinical picture can be expected also in mares, depending on the stage of the disease and its etiology. Harms arising from sexually transmitted diseases can be divided into direct and indirect. Direct damage occurs in the form of endometritis, miscarriage, stillbirths and births of weak foals, and indirect in restricting the traffic of infected and suspicios animals, isolation of the infected ones as well as medical treatment and interrupting mating.

scholarly journals The Risk Factors-Based Nursing Case Management Could Effectively Reduce the Incidence of Pressure Sores in Hospitalized Patients

2021 ◽  
Author(s):  
Hong JIANG ◽  
Yanwen LIANG ◽  
Xinmei LIU ◽  
Donghong YE ◽  
Mengmiao PENG ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Weight ◽  
Case Management ◽  
Hospital Stay ◽  
Operative Time ◽  
Intervention Group ◽  
Hospitalized Patients ◽  
Normal Group ◽  
Control Group ◽  
Pressure Sores

Background: To explore the effects of risk factors-based nursing management on the occurrence of pressure sores in hospitalized patients. Methods: From Jan 2018 to Jun 2018, 289 hospitalized patients were divided into pressure sores group [100] and control group [189] for retrospective analysis. Overall, 260 hospitalized patients from Jun 2018 to Dec 2018 were followed up for nursing intervention. Overall 130 patients received risk factors-based nursing case management were in the intervention group, whereas 130 patients who received routine nursing care were in the control group. The chi-square test and t-test were used to compare the count data and the measurement data between groups, respectively. Results: Age, body weight and proportions of patients with impaired nutritional intake, diabetes or stroke in pressure sores group were higher than those in normal group (P<0.05). Hospital stay and operative time in pressure sores group was longer than those in normal group (P<0.05). The frequency of assistant activity in pressure sores group was significantly lower than that in control group (P<0.05).In addition, the score of uroclepsia in pressure sores group was lower than that in normal group (P<0.05). Patients in the intervention group showed lower risk for pressure sores and more satisfied than patients in control group (P<0.001). Conclusion: Advanced age, high body weight, diabetes and stroke, long hospital stay, long operative time, poor nutritional status and severe uroclepsia were independent risk factors of pressure sores. Risk factorsbased nursing case management can effectively reduce the occurrence and risk of pressure sores for hospitalized patients.

Sign in / Sign up

Export Citation Format

Share Document