scholarly journals Methods of diagnosis in cardio-oncology

2018 ◽  
Vol 9 (1) ◽  
pp. 50-62
Author(s):  
E. V. Plokhova ◽  
A. V. Sorokin ◽  
A. V. Staferov ◽  
D. P. Dundua
Keyword(s):  
Side Effects ◽  
Cancer Therapy ◽  
Early Diagnosis ◽  
Myocardial Dysfunction ◽  
Three Dimensional ◽  
Patients With Cancer ◽  
Dimensional Echocardiography ◽  
After Cancer ◽  
Effects Of Radiation ◽  
Three Dimensional Echocardiography

Early diagnosis and advances in treatment have led to improved survival of patients with cancer, but have also increased morbidity and mortality due to treatment side effects. Cardiovascular diseases (CVDs) are one of the most frequent of these side effects. As a result of the direct effects of radiation therapy and chemotherapy on heart and vessels сan be: acceleration of atherosclerosis, damage of cardiomyocytes and endothelium, and arterial and venous thrombosis. The direct effect of the cancer treatment on the heart is called cardiotoxicity. Early diagnosis and identification of patients at high risk of cardiotoxicity is the first step towards successful prevention of CVD in cancer patients without compromising cancer care, which ultimately leads to a reduction in mortality. Echocardiography is the method of choice for the detection of myocardial dysfunction during and after cancer therapy. New methods of imaging like three-dimensional echocardiography, speckle-tracking echocardiography, cardiac magnetic resonance show a higher sensitivity in detecting of early myocardial dysfunction during cancer therapy. This review outlines the main diagnostic algorithms and approaches used in cardiooncology.

scholarly journals Assessment of Myocardial Dysfunction by Three-Dimensional Echocardiography Combined With Myocardial Contrast Echocardiography in Type 2 Diabetes Mellitus

2021 ◽  
Vol 8 ◽  
Author(s):  
Wei Li ◽  
Xiao-zhou Lv ◽  
Jia Liu ◽  
Jia-hui Zeng ◽  
Min Ye ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Myocardial Dysfunction ◽  
Microvascular Complications ◽  
Contrast Echocardiography ◽  
Three Dimensional ◽  
Left Ventricular ◽  
Dimensional Echocardiography ◽  
Three Dimensional Echocardiography

Background: We aimed to explore the value of combining real-time three-dimensional echocardiography (RT-3DE) and myocardial contrast echocardiography (MCE) in the left ventricle (LV) evaluating myocardial dysfunction in type 2 diabetes mellitus (T2DM) patients.Patients and Methods: A total of 58 T2DM patients and 32 healthy individuals were selected for this study. T2DM patients were further divided into T2DM without microvascular complications (n = 29) and T2DM with microvascular complications (n = 29) subgroups. All participants underwent RT-3DE and MCE. The standard deviation (SD) and the maximum time difference (Dif) of the time to the minimum systolic volume (Tmsv) of the left ventricle were measured by RT-3DE. MCE was performed to obtain the perfusion measurement of each segment of the ventricular wall, including acoustic intensity (A), flow velocity (β), and A·β.Results: There were significant differences in all Tmsv indices except for Tmsv6-Dif among the three groups (all P < 0.05). After heart rate correction, all Tmsv indices of the T2DM with microvascular complications group were prolonged compared with the control group (all P < 0.05). The parameters of A, β, and A·β for overall segments showed a gradually decreasing trend in three groups, while the differences between the three groups were statistically significant (all P < 0.01). For segmental evaluation of MCE, the value of A, β, and A·β in all segments showed a decreasing trend and significantly differed among the three groups (all P < 0.05).Conclusions: The RT-3DE and MCE can detect subclinical myocardial dysfunction and impaired myocardial microvascular perfusion. Left ventricular dyssynchrony occurred in T2DM patients with or without microvascular complications and was related to left ventricular dysfunction. Myocardial perfusion was reduced in T2DM patients, presenting as diffuse damage, which was aggravated by microvascular complications in other organs.

scholarly journals Clinical Manual for Diagnosis, Prevention and Treatment of Cardiovascular Complications of Cancer Therapy. Parts II-V

2017 ◽  
Vol 14 (4) ◽  
pp. 6-19
Author(s):  
I Ye Chazova ◽  
S A Tyulyandin ◽  
M V Vitsenia ◽  
M G Poltavskaya ◽  
M Yu Gilyarov ◽  
...  
Keyword(s):  
Side Effects ◽  
Cancer Therapy ◽  
Arterial Hypertension ◽  
Myocardial Dysfunction ◽  
Cardiovascular Complications ◽  
Cancer Therapies ◽  
Patients With Cancer ◽  
Prevention And Treatment ◽  
Artery Disease

Advances in treatment have led to improved survival of patients with cancer but have also resulted in untoward side effects associated with treatment. Cardiovascular diseases are one of the most frequent of these side effects. Myocardial dysfunction and heart failure, myocardial ischaemia, arrhythmias, arterial hypertension, thromboembolic disease and other cardiovascular complications can interfere with the efficacy of treatment, decrease quality of life, or impact the actual survival of the patient with cancer. This manual discusses concepts for timely diagnosis, intervention, and surveillance of patients treated with cardiotoxic cancer therapies. In this second part оf manual we discuss the diagnostic, prevention and treatment aspects of cancer therapy-related coronary artery disease, arterial hypertension, arrhythmias and pulmonary hypertension.

scholarly journals Clinical Manual for Diagnosis, Prevention and Treatment of Cardiovascular Complications of Cancer Therapy. Part I

2017 ◽  
Vol 14 (3) ◽  
pp. 6-20
Author(s):  
I Ye Chazova ◽  
S A Tyulyandin ◽  
M V Vitsenia ◽  
A G Ovchinnikov ◽  
M G Poltavskaya ◽  
...  
Keyword(s):  
Heart Failure ◽  
Side Effects ◽  
Cancer Therapy ◽  
Myocardial Dysfunction ◽  
Cardiovascular Complications ◽  
Cancer Therapies ◽  
Patients With Cancer ◽  
Prevention And Treatment ◽  
Actual Survival

Advances in treatment have led to improved survival of patients with cancer but have also resulted in untoward side effects associated with treatment. Cardiovascular diseases are one of the most frequent of these side effects. Myocardial dysfunction and heart failure, myocardial ischaemia, arrhythmias, arterial hypertension, thromboembolic disease and other cardiovascular complications can interfere with the efficacy of treatment, decrease quality of life, or impact the actual survival of the patient with cancer. This manual discusses concepts for timely diagnosis, intervention, and surveillance of patients treated with cardiotoxic cancer therapies. In this first part оf manual we discuss the diagnostic, prevention and treatment aspects of cancer therapy-related cardiac dysfunction and heart failure.

scholarly journals Clinical manual for diagnosis, prevention and treatment of cardiovascular complications of cancer therapy. Parts VI-VII

2018 ◽  
Vol 15 (1) ◽  
pp. 6-20
Author(s):  
I Ye Chazova ◽  
S A Tyulyandin ◽  
M V Vitsenia ◽  
E P Panchenko ◽  
Yu A Fedotkina ◽  
...  
Keyword(s):  
Side Effects ◽  
Cancer Therapy ◽  
Myocardial Dysfunction ◽  
Cardiovascular Complications ◽  
Thromboembolic Disease ◽  
Cancer Therapies ◽  
Patients With Cancer ◽  
Prevention And Treatment ◽  
Actual Survival

Advances in treatment have led to improved survival of patients with cancer but have also resulted in untoward side effects associated with treatment. Cardiovascular diseases are one of the most frequent of these side effects. Myocardial dysfunction and heart failure, myocardial ischaemia, arrhythmias, arterial hypertension, thromboembolic disease and other cardiovascular complications can interfere with the efficacy of treatment, decrease quality of life, or impact the actual survival of the patient with cancer. This manual discusses concepts for timely diagnosis, intervention, and surveillance of patients treated with cardiotoxic cancer therapies. In this part оf manual we discuss the diagnostic, prevention and treatment aspects of cancer therapy-related thromboembolism and complications of radiotherapy.

scholarly journals Early Diagnosis of Cardiovascular Diseases in Workers: Role of Standard and Advanced Echocardiography

2018 ◽  
Vol 2018 ◽  
pp. 1-15 ◽  
Author(s):  
Lidia Capotosto ◽  
Francesco Massoni ◽  
Simone De Sio ◽  
Serafino Ricci ◽  
Antonio Vitarelli
Keyword(s):  
Cardiovascular Diseases ◽  
Early Diagnosis ◽  
Myocardial Dysfunction ◽  
Three Dimensional ◽  
Left Ventricular ◽  
Diagnostic Strategy ◽  
Additional Risk Factor ◽  
Multiple Perspectives ◽  
Clinical Tool ◽  
Three Dimensional Echocardiography

Cardiovascular disease (CVD) still remains the main cause of morbidity and mortality and consequently early diagnosis is of paramount importance. Working conditions can be regarded as an additional risk factor for CVD. Since different aspects of the job may affect vascular health differently, it is important to consider occupation from multiple perspectives to better assess occupational impacts on health. Standard echocardiography has several targets in the cardiac population, as the assessment of myocardial performance, valvular and/or congenital heart disease, and hemodynamics. Three-dimensional echocardiography gained attention recently as a viable clinical tool in assessing left ventricular (LV) and right ventricular (RV) function, volume, and shape. Two-dimensional (2DSTE) and, more recently, three-dimensional speckle tracking echocardiography (3DSTE) have also emerged as methods for detection of global and regional myocardial dysfunction in various cardiovascular diseases and applied to the diagnosis of subtle LV and RV dysfunction. Although these novel echocardiographic imaging modalities have advanced our understanding of LV and RV mechanics, overlapping patterns often show challenges that limit their clinical utility. This review will describe the current state of standard and advanced echocardiography in early detection (secondary prevention) of CVD and address future directions for this potentially important diagnostic strategy.

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