scholarly journals GroFi: Large-scale fiber placement research facility

2016 ◽  
Vol 2 ◽  
Author(s):  
Christian Krombholz ◽  
Felix Kruse ◽  
Martin Wiedemann
Keyword(s):  
Production Technology ◽  
Large Scale ◽  
New Materials ◽  
Research Facility ◽  
New Production ◽  
Fiber Placement ◽  
Research Platform ◽  
German Aerospace ◽  
Development And Validation ◽  
Large Research

GroFi is a large research facility operated by the German Aerospace Center’s Center for Lightweight-Production-Technology in Stade. A combination of dierent layup technologies namely (dry) ber placement and tape laying, allows the development and validation of new production technologiesand processes for large-scale composite components. Due to the use of coordinated and simultaneously working layup units a high exibility of the research platform is achieved. This allows the investigation of new materials, technologies and processes on both, small coupons, but also large components such as wing covers or fuselage skins.

scholarly journals BALU: Largest autoclave research facility in the world

2016 ◽  
Vol 2 ◽  
Author(s):  
Hakan Ucan ◽  
Felix Kruse ◽  
Martin Wiedemann
Keyword(s):  
Carbon Fiber ◽  
Production Technology ◽  
Large Scale ◽  
Feedback System ◽  
Curing Process ◽  
Research Facility ◽  
Autoclave Process ◽  
Sensing Systems ◽  
The World ◽  
German Aerospace

Among the large-scale facilities operated at the Center for Lightweight-Production-Technology of the German Aerospace Center in Stade BALU is the world's largest research autoclave. With a loading length of 20m and a loading diameter of 5.8 m the main objective of the facility is the optimization of the curing process operated by components made of carbon fiber on an industrial scale. For this reason, a novel dynamic autoclaving control has been developed that is characterized by peripheral devices to expend the performance of the facility for differential applications, by sensing systems to detect the component state throughout the curing process and by a feedback system, which is capable to intervene into the running autoclave process.

scholarly journals EVo: Net Shape RTM Production Line

2016 ◽  
Vol 2 ◽  
Author(s):  
Sven Torstrick ◽  
Felix Kruse ◽  
Martin Wiedemann
Keyword(s):  
Production Technology ◽  
Production Line ◽  
Resin Transfer Molding ◽  
Hot Forming ◽  
Transfer Molding ◽  
Resin Injection ◽  
Research Platform ◽  
Technology Demonstration ◽  
German Aerospace

EVo research platform is operated by the Center for Lightweight-Production-Technology of the German Aerospace Center in Stade. Its objective is technology demonstration of a fully automated RTM (Resin Transfer Molding) production line for composite parts in large quantities. Process steps include cutting and ply handling, draping, stacking, hot-forming, preform-trimming to net shape, resin injection, curing and demolding.

Fits and Starts: A Current Look at Marine and Industrial Gas Turbine Electric Start Systems

2017 ◽  
Author(s):  
Glenn McAndrews
Keyword(s):  
Gas Turbine ◽  
Gas Turbines ◽  
Life Cycle Cost ◽  
Large Scale ◽  
Past History ◽  
New Technology ◽  
Cost Benefit ◽  
New Production ◽  
Intense Activity ◽  
Industrial Gas Turbine

Electric starter development programs have been the subject of ASME technical papers for over two decades. Offering significant advantages over hydraulic or pneumatic starters, electric starters are now poised to be the preferred choice amongst gas turbine customers. That they are not now the dominant starter in the field after decades of investment and experimentation is attributable to many factors. As with any new technology, progress is often unsteady, depending on budgets, market conditions, customer buy-in, etc. Additionally, technological advances in the parent technologies, in this case electric motors, can abruptly and rapidly change, further disturbing the best laid introduction plans. It is therefore not too surprising that only recently, is the industry beginning to see the deployment of electric starters on production gas turbines. The earliest adoption occurred on smaller gas turbine units, generally less than 10 MW in power. More recently, gas turbines greater than 10 MWs are being sold with electric starters. The authors expect that regardless of their size or fuel supply, most all future gas turbine users will opt for electric starters. This may even include the “larger” frame machines with power greater than 100 MW. Starting with some past history, this paper will not only summarize past development efforts, it will attempt to examine the current deployment of electric starters throughout the marine and industrial gas turbine landscapes. The large-scale acceptance of electric start systems for both new production and retrofit will depend on the favorable cost/benefit assessment when weighing both first cost and life cycle cost. The current and intense activity in electric vehicle applications is giving rise to even more power dense motors. The paper will look at some of these exciting applications, the installed products, and the technologies behind the products. To what extent these new products may serve the needs of the gas turbine community will be the central question this paper attempts to answer.

scholarly journals A new pest management research facility Scions largescale precision track sprayer

2014 ◽  
Vol 67 ◽  
pp. 267-273
Author(s):  
S.F. Gous ◽  
T.M. Withers ◽  
A.J. Hewitt
Keyword(s):  
Large Scale ◽  
Spray Deposition ◽  
Management Research ◽  
Application Research ◽  
Pesticide Application ◽  
Research Facility ◽  
Liquid Pressure ◽  
Plant Canopies ◽  
Wide Range ◽  
Potential Use

A new large scale precision track sprayer has been developed and evaluated for spray deposition and pesticide application research under controlled conditions The spray room is fitted with a 4 m wide electrically driven boom suspended 4 m above ground running on a 12 m long Ibeam It is fitted with 9 independently controlled shut off valves and nozzles Sprays can be applied to live plant canopies up to 3 m tall within a 2 m times; 3 m sample area The number location and type of nozzle on the boom can be altered as can spray liquid pressure and boom speed in order to simulate a wide range of spray application scenarios Calibration of the largescale precision track sprayer has been undertaken for a range of droplet spectra from extremely coarse to very fine This paper documents the calibration results and discusses the potential use of this facility for pesticide application research

scholarly journals Inside the Decentralised Casino: A Longitudinal Study of Actual Cryptocurrency Gambling Transactions

2020 ◽  
Author(s):  
Oliver James Scholten ◽  
David Zendle ◽  
James Alfred Walker
Keyword(s):  
Data Analysis ◽  
Longitudinal Study ◽  
Large Scale ◽  
Online Gambling ◽  
Research Platform ◽  
Player Behaviour ◽  
Typical User

Decentralised gambling applications are a new way for individuals to engage in online gambling. Decentralised gambling applications are distinguished from traditional online casinos in that individuals use cryptocurrency as a stake. Furthermore, rather than being stored on a traditional server, decentralised gambling applications are stored on a cryptocurrency’s blockchain.Previous work in the player behaviour tracking literature has examined the spending profiles of gamblers on traditional online casinos. However, parallel work has not taken place in the decentralised gambling domain. The profile of gamblers on decentralised gambling applications are therefore not known.This paper explores 2,232,741 transactions from 24,234 unique addresses to three such applications operating atop the Ethereum cryptocurrency network over 583 days. We present spending profiles across these applications, providing the first detailed summary of spending behaviours in this technologically advanced domain. We find that the typical user spends approximately \$110 equivalent across a median of 6 bets in a single day, although heavily involved bettors spend approximately \$100,000 equivalent over a median of 644 bets across 35 days. Our findings suggest that the use of decentralised gambling applications typically involves lower and less frequent expenditures than other online casinos, but that the most heavily involved players in this new domain spend substantially more. Our findings also demonstrate the use of these applications as a research platform, specifically for large scale longitudinal in-vivo data analysis.

scholarly journals Accelerating manufacturing to start large-scale supply of a new adenovirus-vectored vaccine within 100 days

2021 ◽  
Author(s):  
Carina CD Joe ◽  
Rameswara R Segireddy ◽  
Cathy Oliveira ◽  
Adam Berg ◽  
Yuanyuan Li ◽  
...  
Keyword(s):  
Production Process ◽  
Large Scale ◽  
Scale Up ◽  
Adenovirus Vector ◽  
Drug Substance ◽  
Economic Modelling ◽  
New Production ◽  
Bulk Drug ◽  
Vectored Vaccine ◽  
Manufacturing Network

The Coalition for Epidemic Preparedness Innovations &rsquo &lsquo 100-day moonshot &rsquo aspires to launch a new vaccine within 100 days of pathogen identification. Here, we describe work to optimize adenovirus vector manufacturing for rapid response, by minimizing time to clinical trial and first large-scale supply, and maximizing the output from the available manufacturing footprint. We describe a rapid viral seed expansion workflow that allows vaccine release to clinical trials within 60 days of antigen sequence identification, followed by vaccine release from globally distributed sites within a further 40 days. We also describe a new perfusion-based upstream production process, designed to maximize output while retaining simplicity and suitability for existing manufacturing facilities. This improves upstream volumetric productivity of ChAdOx1 nCoV-19 by around four-fold and remains compatible with the existing downstream process, yielding drug substance sufficient for 10000 doses from each liter of bioreactor capacity. Transition to a new production process across a large manufacturing network is a major task. In the short term, the rapid seed generation workflow could be used with the existing production process. We also use techno-economic modelling to show that, if linear scale-up were achieved, a single cleanroom containing two 2000 L bioreactors running our new perfusion-based process could supply bulk drug substance for around 120 million doses each month, costing <0.20 EUR/dose. We estimate that a manufacturing network with 32000 L of bioreactor capacity could release around 1 billion doses of a new vaccine within 130 days of genomic sequencing of a new pathogen, in a hypothetical surge campaign with suitable prior preparation and resources, including adequate fill-and-finish capacity. This accelerated manufacturing process, along with other advantages such as thermal stability, supports the ongoing value of adenovirus-vectored vaccines as a rapidly adaptable and deployable platform for emergency response.

scholarly journals The cardiac nanoenvironment: form and function at the nanoscale

2021 ◽  
Author(s):  
Jashan P. Singh ◽  
Jennifer L. Young
Keyword(s):  
Large Scale ◽  
New Materials ◽  
Length Scales ◽  
Form And Function ◽  
Molecular Features ◽  
Wide Range ◽  
Physiological Homeostasis ◽  
Organ Level ◽  
And Function

AbstractMechanical forces in the cardiovascular system occur over a wide range of length scales. At the whole organ level, large scale forces drive the beating heart as a synergistic unit. On the microscale, individual cells and their surrounding extracellular matrix (ECM) exhibit dynamic reciprocity, with mechanical feedback moving bidirectionally. Finally, in the nanometer regime, molecular features of cells and the ECM show remarkable sensitivity to mechanical cues. While small, these nanoscale properties are in many cases directly responsible for the mechanosensitive signaling processes that elicit cellular outcomes. Given the inherent challenges in observing, quantifying, and reconstituting this nanoscale environment, it is not surprising that this landscape has been understudied compared to larger length scales. Here, we aim to shine light upon the cardiac nanoenvironment, which plays a crucial role in maintaining physiological homeostasis while also underlying pathological processes. Thus, we will highlight strategies aimed at (1) elucidating the nanoscale components of the cardiac matrix, and (2) designing new materials and biosystems capable of mimicking these features in vitro.

scholarly journals Six years of total ozone column measurements from SCIAMACHY nadir observations

2009 ◽  
Vol 2 (1) ◽  
pp. 87-98 ◽  
Author(s):  
C. Lerot ◽  
M. Van Roozendael ◽  
J. van Geffen ◽  
J. van Gent ◽  
C. Fayt ◽  
...  
Keyword(s):  
Cross Sections ◽  
Total Ozone ◽  
Large Scale ◽  
European Space Agency ◽  
Data Sets ◽  
Data Set ◽  
Ozone Data ◽  
Space Agency ◽  
German Aerospace ◽  
The Impact

Abstract. Total O3 columns have been retrieved from six years of SCIAMACHY nadir UV radiance measurements using SDOAS, an adaptation of the GDOAS algorithm previously developed at BIRA-IASB for the GOME instrument. GDOAS and SDOAS have been implemented by the German Aerospace Center (DLR) in the version 4 of the GOME Data Processor (GDP) and in version 3 of the SCIAMACHY Ground Processor (SGP), respectively. The processors are being run at the DLR processing centre on behalf of the European Space Agency (ESA). We first focus on the description of the SDOAS algorithm with particular attention to the impact of uncertainties on the reference O3 absorption cross-sections. Second, the resulting SCIAMACHY total ozone data set is globally evaluated through large-scale comparisons with results from GOME and OMI as well as with ground-based correlative measurements. The various total ozone data sets are found to agree within 2% on average. However, a negative trend of 0.2–0.4%/year has been identified in the SCIAMACHY O3 columns; this probably originates from instrumental degradation effects that have not yet been fully characterized.

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