Extramedullary Hematopoiesis in a Man With β-Thalassemia: An Uncommon Cause of an Adrenal Mass

2015 ◽  
Vol 3 (2) ◽  
Author(s):  
Shahryar Zeighami ◽  
Seyed Ali Eslahi ◽  
Mohammad Mehdi Hosseini ◽  
Ali Ariafar ◽  
Sara Pakbaz ◽  
...  
2014 ◽  
Vol 6 (5) ◽  
Author(s):  
Hossein Karami ◽  
Mehrnoush Kosaryan ◽  
Mehrdad Taghipour ◽  
Rayka Sharifian ◽  
Aili Aliasgharian

2020 ◽  
Vol 30 ◽  
pp. 101120 ◽  
Author(s):  
N.H. Kolev ◽  
P.P. Genov ◽  
V.R. Dunev ◽  
B.A. Stoykov

2020 ◽  
Vol 6 (1) ◽  
pp. 030-032
Author(s):  
Elorza-Echaniz Garazi ◽  
Borda-Aguirrezabalaga Nerea ◽  
Aguirre-Allende Ignacio ◽  
Andres-Imaz Ainhoa ◽  
Bollo-Arocena Elisabet ◽  
...  

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Tyler Zachary ◽  
Lillian Lien

Abstract Introduction: Adrenal adenomas are incidentally noted during nonadrenal disease imaging at a rate up to 4%. Frequency of incidentalomas increases with age, most being adrenocortical adenomas. This case highlights an uncommon etiology of such an adrenal mass finding. Case Description: A 37-year-old with a history of hypertension, hypothyroidism, and tobacco use was admitted after post-operative complication. Prior to surgery, she had been experiencing right upper quadrant pain along with 70 lb weight loss and diarrhea. She otherwise had frequent palpitations. Patient had undergone cholecystectomy and common hepatic duct injury was noted. Imaging revealed a 5.3 x 3.5 cm right adrenal mass previously unknown prior to surgery. Hormonal workup was negative for overproduction of aldosterone, cortisol, DHEA-S or metanephrines. Discussion: Patient underwent successful resection of adrenal mass, revealing adrenal adenoma with osseous metaplasia and hematopoiesis. Extramedullary hematopoiesis is a usually discovered incidentally as in this case. Typical sites are the spleen and liver. Cases of adrenal gland manifestations have been reported in the presence of hemoglobinopathies (thalassemia, hereditary spherocytosis) or myelofibrosis. At four-month follow-up, laboratory testing on this patient didn’t suggest any erythrocytic or leukocytic disorder. Conclusion: This case highlights an uncommon finding of hematopoiesis in an adrenal incidentaloma without any underlying hematologic defect or disease. References: Motta, I., Boiocchi, L., Delbini, P., Migone De Amicis, M., Cassinerio, E., Dondossola, D., Rossi, G. and Cappellini, M. D. (2016), A giant adrenal myelolipoma in a beta-thalassemia major patient: Does ineffective erythropoiesis play a role?. Am. J. Hematol., 91: 1281-1282. doi:10.1002/ajh.24446. Stewart P, Newell-Price J. (2016). The Adrenal Cortex. In Melmed S, Polonsky K, Larsen P, Kronenberg H, Williams Textbook of Endocrinology. (13th ed., pp 489-555). Philadelphia, PA: Elsevier


2013 ◽  
Vol 7 (5-6) ◽  
pp. 436 ◽  
Author(s):  
John S. Banerji ◽  
Kumar Manoj Ramani ◽  
A. Devasia

Extramedullary haematopoiesis (EMH) is common in the spleen, liver and lymph nodes, or in para osseus sites. EMH in the adrenal is rare, with fewer than 10 cases reported. We report the case of a 40-year-old male who underwent laparoscopic adrenalectomy for an incidentally detected adrenal mass. The histology showed extramedullary hematopoesis. In patients with a known history of haemolytic anaemia, an enlarged adrenal gland in an asymptomatic individual could represent extramedullary haematopoesis. A confirmatory biopsy would be all that is necessary to avoid adrenalectomy.


2001 ◽  
Vol 31 (12) ◽  
pp. 879-881 ◽  
Author(s):  
S. K. Calhoun ◽  
R. C. Murphy ◽  
N. Shariati ◽  
N. Jacir ◽  
K. Bergman

2017 ◽  
Author(s):  
Abdulrhman Alnaim ◽  
Ming Young Simon Wan ◽  
Tarek Ezzat Abdel-Aziz ◽  
Teng-Teng Chung ◽  
Tom Kurzawinski ◽  
...  
Keyword(s):  

2020 ◽  
Vol 78 (10) ◽  
pp. 663-664
Author(s):  
Renan Ramon Souza LOPES ◽  
Larissa Soares CARDOSO ◽  
Franz ONISHI

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