scholarly journals Respiratory drug delivery to targeted lung lobes

2020 ◽  
Author(s):  
Irina Pyataeva
Keyword(s):  
Drug Delivery ◽  
Respiratory Drug Delivery ◽  
Lung Lobes

Computational Study of Atomization Models and Optimal Design of a Pressurized Inhaler

2021 ◽  
Vol 50 ◽  
pp. 123-134
Author(s):  
Anurag Tiwari ◽  
Siddharth Sharma ◽  
Vivek Kumar Srivastav ◽  
Anuj Jain ◽  
Akshoy Ranjan Paul
Keyword(s):  
Drug Delivery ◽  
Particle Production ◽  
Computational Study ◽  
Nozzle Diameter ◽  
Inhalation Therapy ◽  
Respiratory Drug Delivery ◽  
Minimum Diameter ◽  
Inhaler Device ◽  
Swirl Atomizer ◽  
Pressure Swirl

Respiratory drug delivery has been under the spotlight of research for the past few decades, mainly due to rapid increase of pulmonary diseases. This type of drug delivery offers the highest efficiency for treatment. Despite its numerous benefits, there are some drawbacks in the method of respiratory drug delivery-the most important being poor delivery efficiency and high drug deposition in undesirable regions, such as the oropharynx. This study is focused on improving pressurized inhaler device, which is one of the most used devices for inhalation therapy throughout the world using the results and findings obtained from numerical analysis. In this study, three atomizer models are investigated and found that pressure swirl atomizer model closely represents the atomization phenomenon from a pressurized inhaler device. Parametric study is carried out using three parameters: nozzle diameter, dispersion angle and sheet constant to optimize the performance of the device. It is revealed that a reduction in nozzle diameter and dispersion angle help in generating fine (smaller diameter) particles, whereas increase in sheet constant is responsible for fine particle production. The values of nozzle diameter, dispersion angle and sheet constant are tuned to get the particles with minimum diameter as output which is desirable for the drug particles to get deposited in the smaller airways of lungs and increase the efficiency of drug delivery and improve the device performance.

Respiratory Drug Delivery

CHEST Journal ◽  
1997 ◽  
Vol 111 (5) ◽  
pp. 1155-1156 ◽  
Author(s):  
Paula J. Anderson
Keyword(s):  
Drug Delivery ◽  
Respiratory Drug Delivery

scholarly journals Use of computational fluid dynamics deposition modeling in respiratory drug delivery

2018 ◽  
Vol 16 (1) ◽  
pp. 7-26 ◽  
Author(s):  
P. Worth Longest ◽  
Karl Bass ◽  
Rabijit Dutta ◽  
Vijaya Rani ◽  
Morgan L. Thomas ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Drug Delivery ◽  
Computational Fluid Dynamics ◽  
Respiratory Drug Delivery ◽  
Deposition Modeling

Effervescent dry powder for respiratory drug delivery

2007 ◽  
Vol 65 (3) ◽  
pp. 346-353 ◽  
Author(s):  
Leticia Ely ◽  
Wilson Roa ◽  
Warren H. Finlay ◽  
Raimar Löbenberg
Keyword(s):  
Drug Delivery ◽  
Respiratory Drug Delivery ◽  
Dry Powder
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