Effervescent dry powder for respiratory drug delivery

2007 ◽  
Vol 65 (3) ◽  
pp. 346-353 ◽  
Author(s):  
Leticia Ely ◽  
Wilson Roa ◽  
Warren H. Finlay ◽  
Raimar Löbenberg
Keyword(s):  
Drug Delivery ◽  
Respiratory Drug Delivery ◽  
Dry Powder

Use of a Fundamental Approach to Spray-Drying Formulation Design to Facilitate the Development of Multi-Component Dry Powder Aerosols for Respiratory Drug Delivery

2013 ◽  
Vol 31 (2) ◽  
pp. 449-465 ◽  
Author(s):  
Susan Hoe ◽  
James W. Ivey ◽  
Mohammed A. Boraey ◽  
Abouzar Shamsaddini-Shahrbabak ◽  
Emadeddin Javaheri ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Spray Drying ◽  
Respiratory Drug Delivery ◽  
Dry Powder ◽  
Formulation Design ◽  
Dry Powder Aerosols ◽  
Powder Aerosols

scholarly journals Microfabricated Engineered Particle Systems for Respiratory Drug Delivery and Other Pharmaceutical Applications

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Andres Garcia ◽  
Peter Mack ◽  
Stuart Williams ◽  
Catherine Fromen ◽  
Tammy Shen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Small Molecule ◽  
Pulmonary Delivery ◽  
Respiratory Drug Delivery ◽  
Dry Powder ◽  
Powder Characteristics ◽  
Powder Particles ◽  
Microelectronics Industry ◽  
Delivery Technology ◽  
Microfabrication Techniques

Particle Replication in Non-Wetting Templates (PRINT®) is a platform particle drug delivery technology that coopts the precision and nanoscale spatial resolution inherently afforded by lithographic techniques derived from the microelectronics industry to produce precisely engineered particles. We describe the utility of PRINT technology as a strategy for formulation and delivery of small molecule and biologic therapeutics, highlighting previous studies where particle size, shape, and chemistry have been used to enhance systemic particle distribution properties. In addition, we introduce the application of PRINT technology towards respiratory drug delivery, a particular interest due to the pharmaceutical need for increased control over dry powder characteristics to improve drug delivery and therapeutic indices. To this end, we have produced dry powder particles with micro- and nanoscale geometric features and composed of small molecule and protein therapeutics. Aerosols generated from these particles show attractive properties for efficient pulmonary delivery and differential respiratory deposition characteristics based on particle geometry. This work highlights the advantages of adopting proven microfabrication techniques in achieving unprecedented control over particle geometric design for drug delivery.

Computational Study of Atomization Models and Optimal Design of a Pressurized Inhaler

2021 ◽  
Vol 50 ◽  
pp. 123-134
Author(s):  
Anurag Tiwari ◽  
Siddharth Sharma ◽  
Vivek Kumar Srivastav ◽  
Anuj Jain ◽  
Akshoy Ranjan Paul
Keyword(s):  
Drug Delivery ◽  
Particle Production ◽  
Computational Study ◽  
Nozzle Diameter ◽  
Inhalation Therapy ◽  
Respiratory Drug Delivery ◽  
Minimum Diameter ◽  
Inhaler Device ◽  
Swirl Atomizer ◽  
Pressure Swirl

Respiratory drug delivery has been under the spotlight of research for the past few decades, mainly due to rapid increase of pulmonary diseases. This type of drug delivery offers the highest efficiency for treatment. Despite its numerous benefits, there are some drawbacks in the method of respiratory drug delivery-the most important being poor delivery efficiency and high drug deposition in undesirable regions, such as the oropharynx. This study is focused on improving pressurized inhaler device, which is one of the most used devices for inhalation therapy throughout the world using the results and findings obtained from numerical analysis. In this study, three atomizer models are investigated and found that pressure swirl atomizer model closely represents the atomization phenomenon from a pressurized inhaler device. Parametric study is carried out using three parameters: nozzle diameter, dispersion angle and sheet constant to optimize the performance of the device. It is revealed that a reduction in nozzle diameter and dispersion angle help in generating fine (smaller diameter) particles, whereas increase in sheet constant is responsible for fine particle production. The values of nozzle diameter, dispersion angle and sheet constant are tuned to get the particles with minimum diameter as output which is desirable for the drug particles to get deposited in the smaller airways of lungs and increase the efficiency of drug delivery and improve the device performance.

scholarly journals Aggregated Nanotransfersomal Dry Powder Inhalation of Itraconazole for Pulmonary Drug Delivery

2016 ◽  
Vol 6 (1) ◽  
pp. 57-64 ◽  
Author(s):  
Mehdi Hassanpour Aghdam ◽  
Saeed Ghanbarzadeh ◽  
Yousef Javadzadeh ◽  
Hamed Hamishehkar
Keyword(s):  
Drug Delivery ◽  
Pulmonary Drug Delivery ◽  
Dry Powder Inhalation ◽  
Dry Powder

scholarly journals Dry powder aerosol containing muco-inert particles for excipient enhanced growth pulmonary drug delivery

2020 ◽  
Vol 29 ◽  
pp. 102262
Author(s):  
Guihong Chai ◽  
Amr Hassan ◽  
Tuo Meng ◽  
Lihua Lou ◽  
Jonathan Ma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Pulmonary Drug Delivery ◽  
Dry Powder ◽  
Inert Particles ◽  
Dry Powder Aerosol ◽  
Powder Aerosol
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