Novel allosteric modulators of α7 nicotinic acetylcholine receptor and development of efficient methodologies enabling synthesis of tetrahydroquinolines and unsymmetrical ureas

Discovery of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor: Scaffold hopping approach

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2021.113189 ◽

2021 ◽

Vol 214 ◽

pp. 113189

Author(s):

István Ledneczki ◽

Pál Tapolcsányi ◽

Eszter Gábor ◽

András Visegrády ◽

Márton Vass ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Allosteric Modulators ◽

Scaffold Hopping ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Positive Allosteric Modulators

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Advances in the Discovery of Novel Positive Allosteric Modulators of the α7 Nicotinic Acetylcholine Receptor

Recent Patents on CNS Drug Discovery ◽

10.2174/157488907780832751 ◽

2007 ◽

Vol 2 (2) ◽

Cited By ~ 27

Author(s):

Ramin Faghih ◽

Gregory A. Gfesser ◽

Murali Gopalakrishnan

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Allosteric Modulators ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Positive Allosteric Modulators

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3 α7 Nicotinic Acetylcholine Receptor Agonists and Positive Allosteric Modulators

Progress in Medicinal Chemistry - Progress in Medicinal Chemistry Volume 46 ◽

10.1016/s0079-6468(07)00003-3 ◽

2008 ◽

pp. 131-171 ◽

Cited By ~ 31

Author(s):

Andrew P. Lightfoot ◽

James N.C. Kew ◽

John Skidmore

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Allosteric Modulators ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Receptor Agonists ◽

Positive Allosteric Modulators

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ChemInform Abstract: Allosteric Modulators of the α7 Nicotinic Acetylcholine Receptor

ChemInform ◽

10.1002/chin.200821257 ◽

2008 ◽

Vol 39 (21) ◽

Author(s):

Ramin Faghih ◽

Murali Gopalakrishnan ◽

Clark A. Briggs

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Allosteric Modulators ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine

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Design and synthesis of novel allosteric modulators of α7 nicotinic acetylcholine receptor

10.17760/d20285382 ◽

2017 ◽

Author(s):

Raja

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Allosteric Modulators ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Design And Synthesis

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Characterization of the effects of novel positive allosteric modulators on the functionality of the α7 nicotinic acetylcholine receptor (nAChR)

The FASEB Journal ◽

10.1096/fasebj.2018.32.1_supplement.533.80 ◽

2018 ◽

Vol 32 (S1) ◽

Author(s):

Francis Reilly‐Andujar ◽

José A. Lasalde ◽

José O. Colón

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Allosteric Modulators ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Positive Allosteric Modulators

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Positive allosteric modulators of the α7 nicotinic acetylcholine receptor potentiate glutamate release in the prefrontal cortex of freely-moving rats

Neuropharmacology ◽

10.1016/j.neuropharm.2016.08.033 ◽

2016 ◽

Vol 111 ◽

pp. 78-91 ◽

Cited By ~ 3

Author(s):

D.M. Bortz ◽

B.A. Upton ◽

J.D. Mikkelsen ◽

J.P. Bruno

Keyword(s):

Prefrontal Cortex ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Glutamate Release ◽

Allosteric Modulators ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Freely Moving Rats ◽

Freely Moving ◽

Positive Allosteric Modulators

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HTS-based discovery and optimization of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2021.113560 ◽

2021 ◽

pp. 113560

Author(s):

István Ledneczki ◽

Anita Horváth ◽

Pál Tapolcsányi ◽

János Éles ◽

Katalin Dudás Molnár ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Allosteric Modulators ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Positive Allosteric Modulators

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Identification by virtual screening and functional characterisation of novel positive and negative allosteric modulators of the α7 nicotinic acetylcholine receptor

Neuropharmacology ◽

10.1016/j.neuropharm.2018.07.009 ◽

2018 ◽

Vol 139 ◽

pp. 194-204 ◽

Cited By ~ 3

Author(s):

Charles L.C. Smelt ◽

Victoria R. Sanders ◽

Joseph Newcombe ◽

Richard P. Burt ◽

Tom D. Sheppard ◽

...

Keyword(s):

Virtual Screening ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Allosteric Modulators ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Functional Characterisation

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A Series of α7 Nicotinic Acetylcholine Receptor Allosteric Modulators with Close Chemical Similarity but Diverse Pharmacological Properties

Molecular Pharmacology ◽

10.1124/mol.111.076026 ◽

2012 ◽

Vol 81 (5) ◽

pp. 710-718 ◽

Cited By ~ 37

Author(s):

JasKiran K. Gill ◽

Persis Dhankher ◽

Tom D. Sheppard ◽

Emanuele Sher ◽

Neil S. Millar

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Pharmacological Properties ◽

Allosteric Modulators ◽

Chemical Similarity ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine

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