A Series of α7 Nicotinic Acetylcholine Receptor Allosteric Modulators with Close Chemical Similarity but Diverse Pharmacological Properties

JasKiran K. Gill; Persis Dhankher; Tom D. Sheppard; Emanuele Sher; Neil S. Millar

doi:10.1124/mol.111.076026

A Series of α7 Nicotinic Acetylcholine Receptor Allosteric Modulators with Close Chemical Similarity but Diverse Pharmacological Properties

Molecular Pharmacology ◽

10.1124/mol.111.076026 ◽

2012 ◽

Vol 81 (5) ◽

pp. 710-718 ◽

Cited By ~ 37

Author(s):

JasKiran K. Gill ◽

Persis Dhankher ◽

Tom D. Sheppard ◽

Emanuele Sher ◽

Neil S. Millar

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Pharmacological Properties ◽

Allosteric Modulators ◽

Chemical Similarity ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine

Download Full-text

Discovery of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor: Scaffold hopping approach

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2021.113189 ◽

2021 ◽

Vol 214 ◽

pp. 113189

Author(s):

István Ledneczki ◽

Pál Tapolcsányi ◽

Eszter Gábor ◽

András Visegrády ◽

Márton Vass ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Allosteric Modulators ◽

Scaffold Hopping ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Positive Allosteric Modulators

Download Full-text

Advances in the Discovery of Novel Positive Allosteric Modulators of the α7 Nicotinic Acetylcholine Receptor

Recent Patents on CNS Drug Discovery ◽

10.2174/157488907780832751 ◽

2007 ◽

Vol 2 (2) ◽

Cited By ~ 27

Author(s):

Ramin Faghih ◽

Gregory A. Gfesser ◽

Murali Gopalakrishnan

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Allosteric Modulators ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Positive Allosteric Modulators

Download Full-text

3 α7 Nicotinic Acetylcholine Receptor Agonists and Positive Allosteric Modulators

Progress in Medicinal Chemistry - Progress in Medicinal Chemistry Volume 46 ◽

10.1016/s0079-6468(07)00003-3 ◽

2008 ◽

pp. 131-171 ◽

Cited By ~ 31

Author(s):

Andrew P. Lightfoot ◽

James N.C. Kew ◽

John Skidmore

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Allosteric Modulators ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Receptor Agonists ◽

Positive Allosteric Modulators

Download Full-text

ChemInform Abstract: Allosteric Modulators of the α7 Nicotinic Acetylcholine Receptor

ChemInform ◽

10.1002/chin.200821257 ◽

2008 ◽

Vol 39 (21) ◽

Author(s):

Ramin Faghih ◽

Murali Gopalakrishnan ◽

Clark A. Briggs

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Allosteric Modulators ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine

Download Full-text

Design and synthesis of novel allosteric modulators of α7 nicotinic acetylcholine receptor

10.17760/d20285382 ◽

2017 ◽

Author(s):

Raja

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Allosteric Modulators ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Design And Synthesis

Download Full-text

Characterization of the effects of novel positive allosteric modulators on the functionality of the α7 nicotinic acetylcholine receptor (nAChR)

The FASEB Journal ◽

10.1096/fasebj.2018.32.1_supplement.533.80 ◽

2018 ◽

Vol 32 (S1) ◽

Author(s):

Francis Reilly‐Andujar ◽

José A. Lasalde ◽

José O. Colón

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Allosteric Modulators ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Positive Allosteric Modulators

Download Full-text

Positive allosteric modulators of the α7 nicotinic acetylcholine receptor potentiate glutamate release in the prefrontal cortex of freely-moving rats

Neuropharmacology ◽

10.1016/j.neuropharm.2016.08.033 ◽

2016 ◽

Vol 111 ◽

pp. 78-91 ◽

Cited By ~ 3

Author(s):

D.M. Bortz ◽

B.A. Upton ◽

J.D. Mikkelsen ◽

J.P. Bruno

Keyword(s):

Prefrontal Cortex ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Glutamate Release ◽

Allosteric Modulators ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Freely Moving Rats ◽

Freely Moving ◽

Positive Allosteric Modulators

Download Full-text

HTS-based discovery and optimization of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2021.113560 ◽

2021 ◽

pp. 113560

Author(s):

István Ledneczki ◽

Anita Horváth ◽

Pál Tapolcsányi ◽

János Éles ◽

Katalin Dudás Molnár ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Allosteric Modulators ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Positive Allosteric Modulators

Download Full-text

Identification by virtual screening and functional characterisation of novel positive and negative allosteric modulators of the α7 nicotinic acetylcholine receptor

Neuropharmacology ◽

10.1016/j.neuropharm.2018.07.009 ◽

2018 ◽

Vol 139 ◽

pp. 194-204 ◽

Cited By ~ 3

Author(s):

Charles L.C. Smelt ◽

Victoria R. Sanders ◽

Joseph Newcombe ◽

Richard P. Burt ◽

Tom D. Sheppard ◽

...

Keyword(s):

Virtual Screening ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Allosteric Modulators ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Functional Characterisation

Download Full-text

Novel allosteric modulators of α7 nicotinic acetylcholine receptor and development of efficient methodologies enabling synthesis of tetrahydroquinolines and unsymmetrical ureas

10.17760/d20321690 ◽

2016 ◽

Author(s):

Abhijit Raghunath Kulkarni

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Allosteric Modulators ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine

Download Full-text