scholarly journals Engineered bioactive rosette nanotubes

2018 ◽  
Author(s):  
Fan
Keyword(s):  
Rosette Nanotubes

scholarly journals Scanning Tunneling Microscope Investigation of Self-Assembled Rosette Nanotubes on Highly Ordered Pyrolytic Graphite

2010 ◽  
Vol 16 (S2) ◽  
pp. 470-471 ◽  
Author(s):  
J-Y Cho ◽  
G Borzsonyi ◽  
H Fenniri
Keyword(s):  
Scanning Tunneling Microscope ◽  
Pyrolytic Graphite ◽  
Scanning Tunneling ◽  
Tunneling Microscope ◽  
Microscope Investigation ◽  
Rosette Nanotubes ◽  
Highly Ordered Pyrolytic Graphite ◽  
Self Assembled

Extended abstract of a paper presented at Microscopy and Microanalysis 2010 in Portland, Oregon, USA, August 1 – August 5, 2010.

Hierarchical Self-Assembly of Organic Prolate Nanospheroids from Hydrophobic Rosette Nanotubes

Langmuir ◽  
2008 ◽  
Vol 24 (9) ◽  
pp. 4447-4450 ◽  
Author(s):  
Grigory Tikhomirov ◽  
Takeshi Yamazaki ◽  
Andriy Kovalenko ◽  
Hicham Fenniri
Keyword(s):  
Self Assembly ◽  
Rosette Nanotubes

Helical Rosette Nanotubes as a Potentially More Effective Orthopaedic Implant Material

2004 ◽  
Vol 845 ◽  
Author(s):  
Ai Lin Chun ◽  
Hicham Fenniri ◽  
Thomas J. Webster
Keyword(s):  
Tissue Engineering ◽  
Surface Roughness ◽  
Bone Cells ◽  
In Vitro Study ◽  
Orthopaedic Implant ◽  
Rosette Nanotubes ◽  
Osteoblast Adhesion ◽  
Organic Nanotubes ◽  
First Time

ABSTRACTOrganic nanotubes called helical rosette nanotubes (HRN) have been synthesized in this study for bone tissue engineering applications. They possess intriguing properties for various bionanotechnology applications since they can be designed to mimic the nanostructured constituent components in bone such as collagen fibers and hydroxyapatite (Ca5(PO4)3(OH)) which bone cells are naturally accustomed to interacting with. This is in contrast to currently used orthopaedic materials such as titanium which do not possess desirable nanometer surface roughness. The objective of this in vitro study was to determine bone-forming cell (osteoblasts) interactions on titanium coated with HRNs. Results of this study showed for the first time increased osteoblast adhesion on titanium coated with HRNs compared to those not coated with HRNs. In this manner, this study provided evidence that HRNs should be further considered for orthopaedic applications.

Bioactive Rosette Nanotubes for Bone Tissue Engineering and Drug Delivery

2013 ◽  
pp. 313-357
Author(s):  
Rachel L. Beingessner ◽  
Alaaeddin Alsbaiee ◽  
Baljit Singh ◽  
Thomas J. Webster ◽  
Hicham Fenniri
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Rosette Nanotubes

Synthesis of rhenium chelated MAG3 functionalized rosette nanotubes

2012 ◽  
Vol 53 (13) ◽  
pp. 1645-1651 ◽  
Author(s):  
Alaaeddin Alsbaiee ◽  
Mustapha St. Jules ◽  
Rachel L. Beingessner ◽  
Jae-Young Cho ◽  
Takeshi Yamazaki ◽  
...  
Keyword(s):  
Rosette Nanotubes

Bone morphogenetic factor peptide functionalized rosette nanotubes for orthopedic applications

2014 ◽  
Author(s):  
Linlin Sun ◽  
Thomas J. Webster ◽  
Gujie Mi ◽  
Alaaeddin Alsbaiee ◽  
Usha D. Hemraz ◽  
...  
Keyword(s):  
Rosette Nanotubes ◽  
Orthopedic Applications

Osteoblast Behaviors on Novel Self-assembled Helical Rosette Nanotubes and Hydrogel Composites for Bone Tissue Engineering

2007 ◽  
Vol 1056 ◽  
Author(s):  
Lijie Zhang ◽  
Sharwatie Ramsaywack ◽  
Hicham Fenniri ◽  
Thomas J Webster
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Growth ◽  
Bone Fractures ◽  
Bone Substitutes ◽  
Bone Defects ◽  
The Self ◽  
Rosette Nanotubes ◽  
Osteoblast Adhesion ◽  
Hydrogel Composites

ABSTRACTTo date, although traditional autografts and allografts have been standard methods to treat bone fractures and defects, the formation of biocompatible and injectable scaffolds to induce new bone growth is still a promising method to repair bone defects considering their minimally invasive and osteoinductive features. In this study, a novel bone tissue engineering scaffold based on the self-assembled properties of helical rosette nanotubes (HRNs) and biocompatible hydrogels (specifically, poly(2-hydroxyethyl methacrylate)-pHEMA) was designed to fill bone fractures and repair bone defects. HRNs are a new class of organic nanotubes with a hollow core 11 Å in diameter, which originate from the self-assembly of DNA base pair building blocks (guanine-cytosine) in aqueous solutions. Since HRNs can significantly change their aggregation state and become more viscous based on heating or when added to serum free medium at body temperature, HRNs may provide an exciting therapy to heal bone fractures as injectable bone substitutes. In addition, biocompatible hydrogels were used in conjunction with HRNs in this study to strengthen the bone substitutes and also to serve as a potential drug releasing carrier to stimulate new bone growth at such fracture sites. Two types of HRNs, one with a lysine side chain and the other conjugated to 1% and 10% RGD (arginine-glycine-aspartic acid) peptides on HRNs, were prepared and dispersed into hydrogels. Due to their nanometric features and the helical architecture of HRNs which biomimic collagen, results showed that these HRN hydrogel composites can significantly improve osteoblast adhesion compared to hydrogel controls. Furthermore, 0.01 mg/ml HRNs with RGD embedded in and coated on hydrogels can also enhance osteoblast attachment compared to 0.01 mg/ml HRNs with lysine side chains embedded in and coated on hydrogels. Results showed an increasing trend of osteoblast adhesion on these scaffolds with more RGD groups (10%) on HRNs. In this manner, nanostructured HRN hydrogel composites provide a promising alternative to repair bone defects considering the flexibility in the design of HRNs and their exceptional cytocompatibilty properties.

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