Design, synthesis, methodology development, and evaluation of PET imaging agents targeting cancer and CNS disorders

Design, Synthesis, and Evaluation of (2-Aminocyclopropyl)phenyl Derivatives as Novel Positron Emission Tomography Imaging Agents for Lysine-Specific Demethylase 1 in the Brain

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.0c01937 ◽

2021 ◽

Vol 64 (7) ◽

pp. 3780-3793

Author(s):

Yasushi Hattori ◽

Satoru Matsuda ◽

Rina Baba ◽

Kouta Matsumiya ◽

Shinji Iwasaki ◽

...

Keyword(s):

Positron Emission Tomography ◽

Positron Emission Tomography Imaging ◽

Emission Tomography ◽

Imaging Agents ◽

Design Synthesis ◽

Tomography Imaging ◽

Lysine Specific Demethylase ◽

Positron Emission ◽

The Brain

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Novel gallium(III) complexes transported by MDR1 P-glycoprotein: potential PET imaging agents for probing P-glycoprotein-mediated transport activity in vivo

Chemistry & Biology ◽

10.1016/s1074-5521(00)00111-3 ◽

2000 ◽

Vol 7 (5) ◽

pp. 335-343 ◽

Cited By ~ 35

Author(s):

V Sharma ◽

A Beatty ◽

S-P Wey ◽

J Dahlheimer ◽

CM Pica ◽

...

Keyword(s):

Pet Imaging ◽

Imaging Agents ◽

Transport Activity ◽

P Glycoprotein

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Design, synthesis and biological evaluation of 1,4-Diazobicylco[3.2.2]nonane derivatives as α7-Nicotinic acetylcholine receptor PET/CT imaging agents and agonists for Alzheimer's disease

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2018.09.064 ◽

2018 ◽

Vol 159 ◽

pp. 255-266 ◽

Cited By ~ 2

Author(s):

Shuxia Wang ◽

Yu Fang ◽

Huan Wang ◽

Hang Gao ◽

Guohua Jiang ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Biological Evaluation ◽

Ct Imaging ◽

Imaging Agents ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Design Synthesis ◽

Pet Ct ◽

Synthesis And Biological Evaluation

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Synthesis and evaluation of pyridylbenzofuran, pyridylbenzothiazole and pyridylbenzoxazole derivatives as 18F-PET imaging agents for β-amyloid plaques

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2012.05.011 ◽

2012 ◽

Vol 22 (13) ◽

pp. 4332-4337 ◽

Cited By ~ 14

Author(s):

Britt-Marie Swahn ◽

Johan Sandell ◽

David Pyring ◽

Margareta Bergh ◽

Fredrik Jeppsson ◽

...

Keyword(s):

Pet Imaging ◽

Amyloid Plaques ◽

Imaging Agents ◽

Β Amyloid

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Incorporation of Fluorine into an OBOC Peptide Library by Copper-Free Click Chemistry toward the Discovery of PET Imaging Agents

ACS Combinatorial Science ◽

10.1021/acscombsci.9b00146 ◽

2020 ◽

Vol 22 (3) ◽

pp. 109-113

Author(s):

Emily Murrell ◽

Leonard G. Luyt

Keyword(s):

Click Chemistry ◽

Pet Imaging ◽

Peptide Library ◽

Imaging Agents

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Preparation and evaluation of 17-ethynyl-substituted 16α-[18F]fluoroestradiols: Selective receptor-based PET imaging agents

International Journal of Radiation Applications and Instrumentation Part B Nuclear Medicine and Biology ◽

10.1016/0883-2897(92)90122-f ◽

1992 ◽

Vol 19 (3) ◽

pp. 363-374 ◽

Cited By ~ 14

Author(s):

Henry F. Vanbrocklin ◽

Martin G. Pomper ◽

Kathryn E. Carlson ◽

Michael J. Welch ◽

John A. Katzenellenbogen

Keyword(s):

Pet Imaging ◽

Imaging Agents ◽

Preparation And Evaluation

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Design, Synthesis, and Evaluation of a Low-Molecular-Weight 11C-Labeled Tetrazine for Pretargeted PET Imaging Applying Bioorthogonal in Vivo Click Chemistry

Bioconjugate Chemistry ◽

10.1021/acs.bioconjchem.6b00234 ◽

2016 ◽

Vol 27 (7) ◽

pp. 1707-1712 ◽

Cited By ~ 41

Author(s):

Christoph Denk ◽

Dennis Svatunek ◽

Severin Mairinger ◽

Johann Stanek ◽

Thomas Filip ◽

...

Keyword(s):

Molecular Weight ◽

Click Chemistry ◽

Pet Imaging ◽

Low Molecular Weight ◽

Design Synthesis

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Synthesis of 2-R1-2-(4-(2-fluoroethoxy)benzamido)acetate as potential PET imaging agents

Medicinal Chemistry Research ◽

10.1007/s00044-011-9577-5 ◽

2011 ◽

Vol 21 (6) ◽

pp. 944-951 ◽

Cited By ~ 1

Author(s):

Yong He ◽

Jingli Xu ◽

Hang Liu ◽

Man Feng ◽

Xiao Wang ◽

...

Keyword(s):

Pet Imaging ◽

Imaging Agents

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Overview of a HTHL Hands-On SAV Design Synthesis Methodology

45th AIAA Aerospace Sciences Meeting and Exhibit ◽

10.2514/6.2007-241 ◽

2007 ◽

Author(s):

Xiao Huang ◽

Bernd Chudoba

Keyword(s):

Design Synthesis ◽

Hands On ◽

Synthesis Methodology

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Synthesis and evaluation of novel F-18-labeled pyrimidine derivatives: potential FAK inhibitors and PET imaging agents for cancer detection

RSC Advances ◽

10.1039/c6ra28851k ◽

2017 ◽

Vol 7 (36) ◽

pp. 22388-22399 ◽

Cited By ~ 1

Author(s):

Dawei Wang ◽

Yu Fang ◽

Hang Wang ◽

Xingyu Xu ◽

Jianping Liu ◽

...

Keyword(s):

Cancer Detection ◽

Pet Imaging ◽

Imaging Study ◽

Imaging Agents ◽

Post Injection ◽

Pyrimidine Derivatives ◽

Micropet Imaging ◽

Tumor Bearing ◽

Biodistribution Data

Compound [18F]-8a exhibited good in vivo biodistribution data in mice bearing S180 tumor. And the microPET imaging study of [18F]-8a in S180 tumor-bearing mice was also preformed, which illustrated that the uptake in S180 tumor at 60 min post-injection of [18F]-8a was obvious.

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