scholarly journals De novo asymmetric syntheses of unnatural carbohydrates and their application in structural-activity relationship study of digitoxin analogues as anticancer agents

2012 ◽  
Author(s):  
Hua-Yu Leo Wang
Keyword(s):  
Anticancer Agents ◽  
De Novo ◽  
Activity Relationship ◽  
Asymmetric Syntheses ◽  
Structural Activity Relationship ◽  
Relationship Study

Synthesis and structure-activity relationship study of 8-hydroxyquinoline-derived Mannich bases as anticancer agents

2010 ◽  
Vol 45 (7) ◽  
pp. 2860-2867 ◽  
Author(s):  
Arthur Y. Shaw ◽  
Chun-Yi Chang ◽  
Mei-Yuan Hsu ◽  
Pei-Jung Lu ◽  
Chia-Ning Yang ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Structure Activity Relationship ◽  
Mannich Bases ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Study

Design, Synthesis and Structure-Activity Relationship Study of Coumarin Benzimidazole Hybrid as Potent Antibacterial and Anticancer Agents

2016 ◽  
Vol 1 (15) ◽  
pp. 4638-4644 ◽  
Author(s):  
Megharaja Holiyachi ◽  
Samundeeswari L. Shastri ◽  
Bahubali M. Chougala ◽  
Lokesh A. Shastri ◽  
Shrinivas D. Joshi ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Design Synthesis ◽  
Structure Activity ◽  
Relationship Study

Quantitative structural activity relationship study of bis-tetraazacyclic compounds. A novel series of HIV-1 and HIV-2 inhibitors

1995 ◽  
Vol 38 (19) ◽  
pp. 3865-3873 ◽  
Author(s):  
Heidi C. Joao ◽  
Karen De Vreese ◽  
Rudi Pauwels ◽  
Erik De Clercq ◽  
Geoff W. Henson ◽  
...  
Keyword(s):  
Activity Relationship ◽  
Structural Activity Relationship ◽  
Relationship Study ◽  
Quantitative Structural Activity Relationship ◽  
Hiv 1

scholarly journals Synthesis and Structure–Activity Relationship Study of 1-Phenyl-1-(quinazolin-4-yl)ethanols as Anticancer Agents

2015 ◽  
Vol 6 (3) ◽  
pp. 287-291 ◽  
Author(s):  
Kenta Kuroiwa ◽  
Hirosuke Ishii ◽  
Kenji Matsuno ◽  
Akira Asai ◽  
Yumiko Suzuki
Keyword(s):  
Anticancer Agents ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Study

scholarly journals An efficient synthesis of 4 H -pyrano quinolinone derivatives catalysed by a versatile organocatalyst tetra- n -butylammonium fluoride and their pharmacological screening

2017 ◽  
Vol 4 (11) ◽  
pp. 170764 ◽  
Author(s):  
Pratibha Prasad ◽  
Pratik G. Shobhashana ◽  
Manish P. Patel
Keyword(s):  
Aqueous Ethanol ◽  
Activity Relationship ◽  
Efficient Synthesis ◽  
One Pot ◽  
Experimental Procedure ◽  
Cyclocondensation Reaction ◽  
Structural Activity Relationship ◽  
Relationship Study ◽  
Bacteria And Fungi ◽  
Pharmacological Screening

A new series of indole-based pyranoquinoline derivatives P 1–24 has been synthesized by a one-pot cyclocondensation reaction of 2-(4-substituted)phenyl- N -allyl-indole-3-carbaldehydes 1a–d ; active methylenes 2a–c ; and 4-hydroxy-1-substituted quinolin-2(1 H )-one 3a–b catalysed by an organocatalyst tetra- n -butylammonium fluoride (TBAF) in aqueous ethanol. The easy experimental procedure of the reaction leads to excellent yields of pyranoquinoline derivatives. All the compounds were screened against a representative panel of bacteria and fungi. Some of the compounds are found to be equipotent or more potent than standard drugs as evident from the structural activity relationship study.

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