Routing in Networks-on-Chip with a Three-Dimensional Circulant Topology

2020 ◽  
Vol 26 (1) ◽  
pp. 22-29
Author(s):  
A. Yu. Romanov ◽  
◽  
M. V. Sidorenko ◽  
E. A. Monakhova ◽  
◽  
...  
Keyword(s):  
Three Dimensional ◽  
Networks On Chip ◽  
On Chip

Three-Dimensional Networks-on-Chip Architectures

2009 ◽  
pp. 1-27 ◽  
Author(s):  
Kostas Siozios ◽  
Alexandros Bartzas ◽  
Dimitrios Soudris
Keyword(s):  
Three Dimensional ◽  
Networks On Chip ◽  
On Chip

scholarly journals An automated microfluidic platform integrating functional vascularized organoids-on-chip

2021 ◽  
Author(s):  
Clément Quintard ◽  
Gustav Jonsson ◽  
Camille Laporte ◽  
Caroline Bissardon ◽  
Amandine Pitaval ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Biological Tissues ◽  
Vascular Networks ◽  
Network Systems ◽  
Microvascular Network ◽  
Networks On Chip ◽  
On Chip ◽  
Dimensional Cell

The development of vascular networks on-chip is crucial for the long-term culture of three-dimensional cell aggregates such as organoids, spheroids, tumoroids, and tissue explants. Despite the rapid advancement of microvascular network systems and organoid technology, vascularizing organoids-on-chips remains a challenge in tissue engineering. Moreover, most existing microfluidic devices poorly reflect the complexity of in vivo flows and require complex technical settings to operate. Considering these constraints, we developed an innovative platform to establish and monitor the formation of endothelial networks around model spheroids of mesenchymal and endothelial cells as well as blood vessel organoids generated from pluripotent stem cells, cultured for up to 15 days on-chip. Importantly, these networks were functional, demonstrating intravascular perfusion within the spheroids or vascular organoids connected to neighbouring endothelial beds. This microphysiological system thus represents a viable organ-on-chip model to vascularize biological tissues and should allow to establish perfusion into organoids using advanced microfluidics.

Highly adaptive and deadlock‐free routing for three‐dimensional networks‐on‐chip

2013 ◽  
Vol 7 (6) ◽  
pp. 255-263 ◽  
Author(s):  
Nizar Dahir ◽  
Terrence Mak ◽  
Ra'ed Al‐Dujaily ◽  
Alex Yakovlev
Keyword(s):  
Three Dimensional ◽  
Networks On Chip ◽  
On Chip
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