scholarly journals TOTALANTIOXIDANT STATUS AND NON-ENZYMATIC LINE OF ANTIOXIDANT PROTECTION SYSTEM IN MENOPAUSAL WOMEN

2018 ◽  
pp. 90-94
Author(s):  
N.V. Semenova ◽  
I.M. Madaeva ◽  
L.F. Sholokhov ◽  
L.I. Kolesnikova
Keyword(s):  
Protection System ◽  
Antioxidant Protection ◽  
Menopausal Women ◽  
Antioxidant Protection System

scholarly journals Performance of Metabolic Parameters in Formation of Sleep Disorders in Menopausal Women

2019 ◽  
Vol 3 (6) ◽  
pp. 9-14
Author(s):  
N. V. Semenova ◽  
I. M. Madaeva ◽  
I. M. Mikhalevich ◽  
L. I. Kolesnikova
Keyword(s):  
Lipid Peroxidation ◽  
Sleep Disorders ◽  
Protection System ◽  
Antioxidant Protection ◽  
System Parameters ◽  
Informative Parameters ◽  
Menopausal Women ◽  
Perimenopausal Women ◽  
Total Antioxidant ◽  
Antioxidant Protection System

Background. It is known that menopausal women suffer from sleep disorders. As additional diagnostic methods, it is possible to use the equations of linear classification functions.Aim: to determine the most informative parameters among the lipid profile, the “lipid peroxidation – antioxidant protection” system parameters and the melatonin secretion chronobiological rhythms in menopausal women with sleep disorders.Materials and methods. 56 perimenopausal women and 70 postmenopausal ones in accordance with the inclusion criteria participated in this study. Diagnoses of insomnia and obstructive sleep apnea syndrome were made according to the results of specialized somnological questionnaires and polysomnographic monitoring. Spectrophotometric methods for studying of lipid metabolism and the “lipid peroxidation – antioxidant protection” system parameters, an enzyme immunoassay method for determining melatonin were also used. A multidimensional discriminant analysis to reveal the most informative parameters among the parameters studied was used.Results. The most informative indicators of the metabolic system for sleep disorders in perimenopausal women with insomnia are melatonin 06.00–07.00 h, melatonin 18.00–19.00 h, melatonin 23.00–00.00 h, ketodienes and conjugated trienes, oxidized glutathione; with insomnia and OSAS – melatonin 06.00–07.00 h, melatonin 12.00–13.00 h, melatonin 23.00–00.00 h, substrates with conjugated double bonds, total cholesterol; in postmenopausal women with insomnia – diene conjugates, α-tocopherol, total antioxidant capacity, active products of thiobarbituric acid, reduced glutathione; with insomnia and OSAS – total antioxidant capacity, α-tocopherol, substrates with conjugated double bonds.Conclusions. The results obtained indicate a great strain in the antioxidant protection system in menopausal women with sleep disorders in response to changes in free radical homeostasis.

Antioxidant protection system parameters in Caucasian and Asian menopausal women

Maturitas ◽  
2019 ◽  
Vol 124 ◽  
pp. 163
Author(s):  
Natalya Semenova ◽  
Irina Madaeva ◽  
Marina Darenskaya ◽  
Lyubov Kolesnikova
Keyword(s):  
Protection System ◽  
Antioxidant Protection ◽  
System Parameters ◽  
Menopausal Women ◽  
Antioxidant Protection System

scholarly journals The state of antioxidant protection system in cows under the influence of heavy metals

2020 ◽  
Vol 11 (2) ◽  
pp. 237-242
Author(s):  
L. G. Slivinska ◽  
A. R. Shcherbatyy ◽  
B. O. Lukashchuk ◽  
B. V. Gutyj
Keyword(s):  
Heavy Metals ◽  
Superoxide Dismutase ◽  
Glutathione Peroxidase ◽  
Malonic Dialdehyde ◽  
Protection System ◽  
Lipid Hydroperoxides ◽  
Technogenic Pollution ◽  
Antioxidant Protection ◽  
Diene Conjugates ◽  
Antioxidant Protection System

A highly relevant problem of modern veterinary science is the study of features and mechanisms of combined action of the most common heavy metals – cadmium and plumbum and their influence on the body of humans and animals in the regions of Ukraine under technogenic pollution. The purpose of the work was to study the influence of heavy metals on the state of the antioxidant protection system of cows, in particular on the content of lipid peroxidation products (malonic dialdehyde, lipid hydroperoxides and diene conjugates), and activity of antioxidant enzymes (glutathione peroxidase and superoxide dismutase), depending on the distance to the heaps of mines in the coal basin. The study objects were cows of black-and-white breed at the age of 3–7 years. It was established that this parameter in the place with the highest concentration of diene conjugates in the blood of cows was by 25.8 % higher compared to the place of low concentration and 12.1 % higher compared to the place with medium concentration. In the place with the highest content of lipid hydroperoxides in the blood of cows the parameter was 23.7 % higher compared to the cows from the place with the low content. The concentration of lipid hydroperoxides in the blood of cows from the place with the medium content was 16.7% higher compared to the cows from the place with the low content. The parameter from the place with the lowest content of lipid hydroperoxides in the blood of cows was 12.1% lower compared to the place with the highest content. The level of malonic dialdehyde in the blood of cows from the technogenic pollution zone in the place with the largest amount was higher by 36.2; 34.0 and 18.8 % – compared to places with medium and low levels, respectively. The activity of superoxide dismutase in the blood of cows in the place with its highest activity was 0.284 ± 0.0099 % block. reac/g Hb, and in the place with the lowest activity – 0.23 ± 0.0051 % block. reac/g Hb. The activity of glutathione peroxidase in the blood of cows in farms of the technogenic pollution zone depended on the distance to the mine. These researches will further develop effective methods of treating cows under the influence of heavy metals, in particular regarding the antioxidant system.

scholarly journals Functional State of the Thyroid Gland and Lipid Peroxidation and Antioxidant Protection System in Women of Reproductive Age with Chronic Form of Parenteral Viral Hepatitis

2019 ◽  
Vol 4 (1) ◽  
pp. 31-35
Author(s):  
Maria A. Rashidova ◽  
Leonid F. Sholokhov ◽  
Marina A. Darenskaya ◽  
Lyubov I. Kolesnikova
Keyword(s):  
Lipid Peroxidation ◽  
Viral Hepatitis ◽  
Functional State ◽  
Chronic Viral Hepatitis ◽  
Protection System ◽  
Reproductive Age ◽  
Control Group ◽  
Antioxidant Protection ◽  
Chronic Form ◽  
Antioxidant Protection System

Background.Chronic viral hepatitis is a complex global problem and is still far from being solved. Many researchers point out influence of viral hepatitis on the reproductive system of women.Aim.To identify features of the functional state of pituitary-thyroid units of neuroendocrinal regulation, and to evaluate lipid peroxidation – antioxidant protection with determination of the oxidative stress coefficient in perimenopausal women with chronic form of hepatitis.Materials and methods. Study included 44 women with chronic viral hepatitis and 28 healthy women of the same age. Immunoabsorbent, spectrophotometric, fluorometric and statistical methods were used.Results.In patients with chronic viral hepatitis, we detected an increase in thyroxine levels – by 29.6% (р < 0.001) and free triiodothyronine values – by 65.7% (р = 0.008) in comparison with the control group. In the group with chronic viral hepatitis, the TBA-reactive products level increased by 1.9 times (р = 0.006), and superoxide dismutase activity decreased by 1.3 times (р < 0.001), total antioxidant activity – by 1.7 times (р < 0.001) and α-tocopherol level – by 1.3 times (р = 0.005) in comparison with the control group.Conclusions. The obtained data demonstrate the features of the pituitary-thyroid system functioning and the lipid peroxidation – antioxidant protection system in patients with chronic hepatitis. The chronic form of hepatitis is characterized by metabolic disorders that require a more careful approach in diagnosis and management.

scholarly journals State of the antioxidant protection system of rat liver in ischemia and reperfusion

2020 ◽  
Vol 24 (1) ◽  
pp. 93-104
Author(s):  
Konstantin Andreevich Popov ◽  
Ilia Mikhaylovich Bykov ◽  
Igor Yuryevich Tsymbalyuk ◽  
Yana Evgenievna Denisova ◽  
Anzhela Nikolaevna Stolyarova ◽  
...  
Keyword(s):  
Rat Liver ◽  
The State ◽  
Protection System ◽  
Cytosolic Fraction ◽  
Rat Liver Mitochondria ◽  
Ischemia And Reperfusion ◽  
Antioxidant Protection ◽  
Reperfusion Period ◽  
Mitochondrial Suspension ◽  
Antioxidant Protection System

Purpose: determination of the state of the antioxidant protection system of the cytosolic fraction and suspension of rat liver mitochondria after experimental ischemia and reperfusion. Materials and methods: the study was conducted using white mature rats, divided into 3 groups: the control group (n = 15); The 2nd group of animals (n = 15), from which the liver was taken after 15 minutes of liver ischemia; the 3rd group of rats (n = 15), from which the liver was taken after a 15-minute reperfusion period, followed by a 15-minute ischemic period. Mitochondrial suspension and cytosolic fraction were isolated from liver tissue. Results: the obtained research results showed the presence of certain pathobiochemical changes in the suspension of mitochondria and the cytosolic fraction after ischemia or reperfusion. In the mitochondrial suspension during the reperfusion period it was found an adaptive increase in the activity of glutathione peroxidase by 39% and glutathione reductase by 61%. In the cytosolic fraction, it was the most remarkable increase of the total antioxidant capacity by 38% already during ischemia and a progressive decrease in the level of reduced glutathione form by 26% in ischemic and 55% in reperfusion period. The change in the state of the antioxidant system occurred against the background of an increase in the number of products of oxidative modifications of biomolecules by 40% during ischemia and 2.2 times after reperfusion. Conclusion: The results indicate the need to develop not only a mitochondria-oriented correction of oxidative disorders, but also active support for the components of the cytosol, which provide the main accumulation of free radical damage products and their subsequent removal from the cell, which is essential for survival.

scholarly journals THE INHIBITING EFFECT OF FS-1 DRUG ON THE ANTIOXIDANT PROTECTION SYSTEM OF MYCOBACTERIA TUBERCULOSIS

2021 ◽  
Vol 2 (344) ◽  
pp. 64-73
Author(s):  
B. Kerimzhanova ◽  
A. Jumagaziyeva ◽  
N. Аkhatullina ◽  
Zh. Iskakbayeva ◽  
E. Sakhipov
Keyword(s):  
Protection System ◽  
Antioxidant Protection ◽  
Inhibiting Effect ◽  
Antioxidant Protection System ◽  
Mycobacteria Tuberculosis

scholarly journals The intensity of the processes of oxidative modification of proteins and the activity of enzymes of the antioxidant protection system of broiler chickens under the action of vitamins E and C

2019 ◽  
Vol 2 (3) ◽  
pp. 19-22
Author(s):  
L. Romanovych ◽  
B. Kurtyak ◽  
D. Mudrak
Keyword(s):  
Antioxidant Enzymes ◽  
Broiler Chickens ◽  
Protein Structures ◽  
Oxidative Modification ◽  
Protection System ◽  
Inhibitory Influence ◽  
Antioxidant Protection ◽  
Oxidative Modification Of Proteins ◽  
Vitamins E And C ◽  
Antioxidant Protection System

Chickens in the control group received a standard ration, the first experimental – ration with the addition of tocopherol acetate, the second experimental – ascorbic acid, and the third – a complex of these vitamins. On the basis of the conducted researches the influence of vitamin supplements on the indexes of oxidation intensity of lipid and protein structures was analyzed. The intensity of the processes of oxidative modification of proteins largely depends on the level of vitamins E and C in the ration of broiler chickens. Supplementation with vitamin C and with vitamin E resulted in an inhibitory influence on the content of OMP products, the level of which is largely regulated by the enzyme and non-enzymatic links of the antioxidant protection system. Searches have shown the stimulating influence of the addition of vitamins on the activity of antioxidant enzymes. In particular, SOD activity increased by 19 % on the 34th day, by 32 % on the 41st day, whereas glutathione peroxidase activity was 5.7 and 20.8 %, respectively, compared to the control chickens group. An increase in the activity of antioxidant enzymes occurred against the background of a decrease in the intensity of oxidation processes. At the same time, there was also an increase in the content of recovered glutathione in the blood of chickens of the second and third experimental groups at 34th and 41st days of age. Thereby, searches have shown that supplementing the ration with vitamins E and C with a positive influence on the organism's adaptive capacity and antioxidant potential, which is extremely important to ensure the metabolic homeostasis of chickens during critical periods of their cultivation.

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