scholarly journals Sensitivity analysis of transient bioheat transfer during thermal injury formation of biological tissue

2014 ◽  
Vol 13 (2) ◽  
pp. 33-42
Author(s):  
Marek Jasinski ◽  
Keyword(s):  
Sensitivity Analysis ◽  
Biological Tissue ◽  
Thermal Injury ◽  
Bioheat Transfer

scholarly journals Characterization of Thermal Damage Due to Two-Temperature High-Order Thermal Lagging in a Three-Dimensional Biological Tissue Subjected to a Rectangular Laser Pulse

Polymers ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 922
Author(s):  
Hamdy M. Youssef ◽  
Najat. A. Alghamdi
Keyword(s):  
Fourier Transform ◽  
Biological Tissue ◽  
Thermal Damage ◽  
Three Dimensional ◽  
Bioheat Transfer ◽  
Conduction Model ◽  
Conductive Temperature ◽  
Arrhenius Integral ◽  
The Fourier Transform ◽  
Two Temperature

The use of lasers and thermal transfers on the skin is fundamental in medical and clinical treatments. In this paper, we constructed and applied bioheat transfer equations in the context of a two-temperature heat conduction model in order to discuss the three-dimensional variation in the temperature of laser-irradiated biological tissue. The amount of thermal damage in the tissue was calculated using the Arrhenius integral. Mathematical difficulties were encountered in applying the equations. As a result, the Laplace and Fourier transform technique was employed, and solutions for the conductive temperature and dynamical temperature were obtained in the Fourier transform domain.

Experimental and Numerical Evaluation of Small-Scale Cryosurgery Using Ultrafine Cryoprobe

2013 ◽  
Author(s):  
Junnosuke Okajima ◽  
Atsuki Komiya ◽  
Shigenao Maruyama
Keyword(s):  
Numerical Simulation ◽  
Temperature Distribution ◽  
Biological Tissue ◽  
Bioheat Transfer ◽  
Small Scale ◽  
Outer Diameter ◽  
Two Phase ◽  
Inner Diameter ◽  
Surgical Treatments ◽  
Tube Structure

Cryosurgery is one of the surgical treatments using a frozen phenomenon in biological tissue. In order to reduce the invasiveness of cryosurgery, the miniaturization of cryoprobe, which is a cooling device for cryosurgery, has been required. The authors have developed a ultrafine cryoprobe for realizing low-invasive cryosurgery by the local freezing. The objective of this study is to evaluate the small-scale cryosurgery using the ultrafine cryoprobe experimentally and numerically. The ultrafine cryoprobe has a double-tube structure and consists of two stainless microtube. The outer diameter of ultrafine cryoprobe was 550 μm. The inner tube, which has 70 μm in inner diameter, depressurizes the high-pressure liquidized refrigerant. Depressurized refrigerant changes its state to two-phase and passes through the gap between outer and inner tube. The alternative Freon of HFC-23 was used as a refrigerant, which has the boiling point of −82°C at 0.1 MPa. The cooling performance of this ultrafine cryoprobe was tested by the freezing experiment of the gelated water kept at 37°C. The gelated water at 37°C is a substitute of the biological tissue. As a result of the cooling in 1 minute, the surface temperature of the ultrafine cryoprobe was reached at −35°C and the radius of frozen region was 2 mm. In order to evaluate the temperature distribution in the frozen region, the numerical simulation was conducted. The two-dimensional axisymmetric bioheat transfer equation with phase change was solved. By using the result from the numerical simulation, the temperature distribution in the frozen region and expected necrosis area is discussed.

Identification of the cancer ablation parameters during RF hyperthermia using gradient, evolutionary and hybrid algorithms

2017 ◽  
Vol 27 (3) ◽  
pp. 674-697 ◽  
Author(s):  
Marek Paruch
Keyword(s):  
Inverse Problem ◽  
Temperature Field ◽  
Electric Field ◽  
Electric Potential ◽  
Biological Tissue ◽  
Transfer Problem ◽  
Biological Tissues ◽  
Bioheat Transfer ◽  
System Of Equations ◽  
Content Type

Purpose The purpose of this study is to show that the methods of the numerical simulation can be a very effective tool for a proper choice of control parameters of artificial hyperthermia. An electromagnetic field induced by two external electrodes and a temperature field resulting from electrodes action in a 3D domain of biological tissue is considered. An important problem is the appropriate directing of heat in the region of tumor, so as to avoid damaging healthy cells surrounding the tumor. Recently, to concentrate the heat on the tumor, magnetic nanoparticles, which are introduced into the tumor, were used. The nanoparticles should be made of material that ensures appropriate magnetic properties and has a high biocompatibility with the biological tissue. External electric field causes the heat generation in the tissue domain. Design/methodology/approach The distribution of electric potential in the domain considered is described by the Laplace system of equations, while the temperature field is described by the Pennes’ system of equations. These problems are coupled by source function being the additional component in the Pennes’ equation and resulting from the electric field action. The boundary element method is applied to solve the coupled problem connected with the heating of biological tissues. Findings The aim of investigations is to determine an electric potential of external electrodes and the number of nanoparticles introduced to a tumor region to obtain the artificial hyperthermia state. The tests performed showed that the proposed tool to solve the inverse problem provides correct results. Research limitations/implications In the paper the steady state bioheat transfer problem is considered, so the thermal damage is a function of the temperature only. Therefore, the solution can be considered as the maximum ablation zone of cancer. Additionally, the choice of appropriate parameters will be affected on the position and shape of the tumor and the electrodes. Originality/value In the paper the inverse problem has been solved using the evolutionary algorithm, gradient method and hybrid algorithm which is a combination of the two previous.

scholarly journals Modeling of thermal injury produced by laser ablation of biological tissue

1993 ◽  
Author(s):  
Vasan Venugopalan ◽  
Norman S. Nishioka ◽  
B. B. Mikic
Keyword(s):  
Laser Ablation ◽  
Biological Tissue ◽  
Thermal Injury

scholarly journals Noninvasive imaging analysis of biological tissue associated with laser thermal injury

2017 ◽  
Vol 40 (2) ◽  
pp. 106-112 ◽  
Author(s):  
Cheng-Jen Chang ◽  
De-Yi Yu ◽  
Yen-Chang Hsiao ◽  
Kuang-Hua Ho
Keyword(s):  
Biological Tissue ◽  
Thermal Injury ◽  
Noninvasive Imaging ◽  
Imaging Analysis

Estimation of temperature distribution in biological tissue by using solutions of bioheat transfer equation

2008 ◽  
Vol 37 (6) ◽  
pp. 374-386 ◽  
Author(s):  
Shigenao Maruyama ◽  
Junnosuke Okajima ◽  
Atsuki Komiya ◽  
Hiroki Takeda
Keyword(s):  
Temperature Distribution ◽  
Biological Tissue ◽  
Transfer Equation ◽  
Bioheat Transfer ◽  
Bioheat Transfer Equation

scholarly journals Bioheat transfer in a spherical biological tissue: a comparison among various models

2019 ◽  
Vol 1224 ◽  
pp. 012001 ◽  
Author(s):  
Assunta Andreozzi ◽  
Luca Brunese ◽  
Marcello Iasiello ◽  
Claudio Tucci ◽  
Giuseppe Peter Vanoli
Keyword(s):  
Biological Tissue ◽  
Bioheat Transfer

Modeling of Laser-Soft Tissue Interactions Using the Dual-Phase Lag Equation: Sensitivity Analysis with Respect to Selected Tissue Parameters

2017 ◽  
Vol 379 ◽  
pp. 108-123
Author(s):  
Ewa Majchrzak ◽  
Marek Jasiński ◽  
Łukasz Turchan
Keyword(s):  
Sensitivity Analysis ◽  
Soft Tissue ◽  
Laser Irradiation ◽  
Soft Tissues ◽  
Initial Conditions ◽  
Internal Heat ◽  
Bioheat Transfer ◽  
Phase Lag ◽  
Dual Phase ◽  
Coupled Equations

Thermal processes occurring in soft tissues are subjected to laser irradiation are analyzed. The transient bioheat transfer is described by the generalized dual-phase lag model. This model consists of two coupled equations concerning the tissue and blood temperatures supplemented by the appropriate boundary and initial conditions. The efficiency of the internal heat source connected to the laser irradiation results from the solution of the diffusion equation. This approach is acceptable when the scattering dominates over the absorption for wavelengths between 650 and 1300 nm, and just such a situation occurs in the case of soft tissues. Sensitivity analysis with respect to the parameters occurring in the mathematical model is done using the direct approach (differentiation of the basic equations and the boundary-initial conditions with respect to the parameter considered), especially the absorption coefficient and scattering coefficient of the soft tissue are considered. At the stage of numerical modeling the basic problem and additional problems connected with the sensitivity functions are solved using the finite difference method. In the final part the conclusions and examples of computations are presented.

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