scholarly journals Evaluation of Dopamine Receptor Integrity after Sevo fl urane Exposure in Neonatal Rat Brain Using Positron Emission Tomography

2018 ◽  
Vol 5 (1) ◽  
pp. 001-006
Author(s):  
Xuan Zhang
Keyword(s):  
Positron Emission Tomography ◽  
Rat Brain ◽  
Dopamine Receptor ◽  
Neonatal Rat ◽  
Emission Tomography ◽  
Positron Emission ◽  
Neonatal Rat Brain

Central D2 receptor blockade and antipsychotic effects of neuroleptics. Preliminary study with positron emission tomography

1990 ◽  
Vol 5 (4) ◽  
pp. 231-240 ◽  
Author(s):  
JL Martinot ◽  
ML Paillère-Martinot ◽  
C Loc'h ◽  
P Péron Magnan ◽  
B Mazoyer ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Dopamine Receptor ◽  
Negative Symptoms ◽  
Receptor Occupancy ◽  
Emission Tomography ◽  
Receptor Blockade ◽  
Low Doses ◽  
Receptor Density ◽  
Positron Emission ◽  
Significant Difference

SummaryThe striatal D2 receptor density/affinity index was assessed using positron emission tomography and 76Br-Bromolisuride in 15 schizophrenics, first untreated, and afterwards receiving neuroleptics, and in 14 control subjects. The patients received low or conventional doses of neuroleptics. The schizophrenics receiving low doses (n = 6) had preponderant negative symptoms. Mean D2 receptor occupancy was 24 ± 20%. Despite this weak central D2 receptor blockade, a significant decrease in negative symptoms was observed, a result consistent with the hypothesis of a disinhibitory action of some neuroleptics administered in low doses. The patients treated with conventional doses (n = 9) had mixed positive and negative symptoms, and the mean D2 receptor occupancy was 54 ± 13%. Significant decreases in positive symptoms, but also in negative symptoms, were obtained with this treatment. Before treatment, there was no significant difference in the striatal D2 receptor density/affinity index between: 1) patients and controls, 2) negative and mixed schizophrenics, and 3) the subsequent responder and non-responder patients. In addition, the D2 dopamine receptor occupancy by neuroleptics did not significantly differ in responder or nonresponder patients, suggesting that the central D2 dopamine receptor blockade is a necessary, but insufficient condition to account for the antipsychotic effect of neuroleptics.

scholarly journals D1-Dopamine Receptor Availability in First-Episode Neuroleptic Naive Psychosis Patients

2019 ◽  
Vol 22 (7) ◽  
pp. 415-425 ◽  
Author(s):  
Per Stenkrona ◽  
Granville J Matheson ◽  
Christer Halldin ◽  
Simon Cervenka ◽  
Lars Farde
Keyword(s):  
Positron Emission Tomography ◽  
Dopamine Receptor ◽  
Emission Tomography ◽  
First Episode ◽  
Control Subjects ◽  
Positron Emission ◽  
Significant Difference ◽  
D1 Dopamine Receptor ◽  
Dorsolateral Prefrontal ◽  
Dopamine Receptor Binding

Abstract Background Positron emission tomography studies examining differences in D1-dopamine receptor binding between control subjects and patients with schizophrenia have been inconsistent, reporting higher, lower, and no difference in the frontal cortex. Exposure to antipsychotic medication has been suggested to be a likely source of this heterogeneity, and thus there is a need for studies of patients at early stages of the disorder who have not been exposed to such drugs. Methods Here, we compared 17 healthy control subjects and 18 first-episode neuroleptic naive patients with schizophrenia or schizophreniform psychosis using positron emission tomography and the D1-dopamine receptor radioligand [11C]SCH23390. Results We observed a statistically significant difference in the dorsolateral prefrontal cortex. Contrary to our expectations, patients had less D1-dopamine receptor availability with a moderate effect size. In a Bayesian analysis, we show that the data are over 50 times more likely to have occurred under the decrease as opposed to the increase hypothesis. This effect was not global, as our analysis showed that the null hypothesis was preferred over either hypothesis in the striatum. Conclusions This investigation represents the largest single sample of neuroleptic-naive patients examined for D1-dopamine receptor availability using PET and suggests a reduction of prefrontal D1-dopamine receptor density in the pathophysiology of schizophrenia. However, further work will be required to reach a consensus.

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