Striatal dopamine receptor occupancy during and following withdrawal from neuroleptic treatment: correlative evaluation by positron emission tomography and plasma prolactin levels

1989 ◽  
Vol 99 (4) ◽  
pp. 463-472 ◽  
Author(s):  
J. C. Baron ◽  
J. L. Martinot ◽  
H. Cambon ◽  
J. P. Boulenger ◽  
M. F. Poirier ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Dopamine Receptor ◽  
Receptor Occupancy ◽  
Striatal Dopamine ◽  
Emission Tomography ◽  
Plasma Prolactin ◽  
Neuroleptic Treatment ◽  
Positron Emission ◽  
Striatal Dopamine Receptor

Central D2 receptor blockade and antipsychotic effects of neuroleptics. Preliminary study with positron emission tomography

1990 ◽  
Vol 5 (4) ◽  
pp. 231-240 ◽  
Author(s):  
JL Martinot ◽  
ML Paillère-Martinot ◽  
C Loc'h ◽  
P Péron Magnan ◽  
B Mazoyer ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Dopamine Receptor ◽  
Negative Symptoms ◽  
Receptor Occupancy ◽  
Emission Tomography ◽  
Receptor Blockade ◽  
Low Doses ◽  
Receptor Density ◽  
Positron Emission ◽  
Significant Difference

SummaryThe striatal D2 receptor density/affinity index was assessed using positron emission tomography and 76Br-Bromolisuride in 15 schizophrenics, first untreated, and afterwards receiving neuroleptics, and in 14 control subjects. The patients received low or conventional doses of neuroleptics. The schizophrenics receiving low doses (n = 6) had preponderant negative symptoms. Mean D2 receptor occupancy was 24 ± 20%. Despite this weak central D2 receptor blockade, a significant decrease in negative symptoms was observed, a result consistent with the hypothesis of a disinhibitory action of some neuroleptics administered in low doses. The patients treated with conventional doses (n = 9) had mixed positive and negative symptoms, and the mean D2 receptor occupancy was 54 ± 13%. Significant decreases in positive symptoms, but also in negative symptoms, were obtained with this treatment. Before treatment, there was no significant difference in the striatal D2 receptor density/affinity index between: 1) patients and controls, 2) negative and mixed schizophrenics, and 3) the subsequent responder and non-responder patients. In addition, the D2 dopamine receptor occupancy by neuroleptics did not significantly differ in responder or nonresponder patients, suggesting that the central D2 dopamine receptor blockade is a necessary, but insufficient condition to account for the antipsychotic effect of neuroleptics.

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