scholarly journals Evaluating plasma Digoxin concentration after an intravenous loading dose in patients with renal failure

2021 ◽  
pp. 033-037
Author(s):  
Eslami Vahid ◽  
Mortezapour Fatemeh ◽  
Samavat Shiva ◽  
Ziae Shadi ◽  
Gheymati Azin
Keyword(s):  
Renal Failure ◽  
Digoxin Concentration ◽  
Loading Dose ◽  
Plasma Digoxin ◽  
Plasma Digoxin Concentration

Digoxin toxicit in chronic renal failure: treatment by multiple dose activated charcoal intestinal dialysis

1997 ◽  
Vol 16 (12) ◽  
pp. 733-735 ◽  
Author(s):  
Julian AJH Critchley ◽  
Lester AH Critchley
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Activated Charcoal ◽  
Multiple Dose ◽  
Digoxin Concentration ◽  
Digoxin Toxicity ◽  
Plasma Digoxin ◽  
Plasma Digoxin Concentration ◽  
Wide Range ◽  
Repeated Doses

1 Digoxin toxicity can result from overdose or iatrogenic causes, especially if renal function is impaired. 2 We present a case of digoxin toxicity presenting with severe bradycardia and hypotension in a 66 year old man with chronic renal failure. Regular haemodia lysis had, as predicted, failed to reduce his plasma digoxin concentration. Digoxin specific antibody fragments (Fab) were not readily available and their use was probably inappropriate as they are normally renally eliminated. 3 The patient was successfully treated by two prolonged courses of intestinal dialysis with repeated doses of activated charcoal over 48 and 72 h and totaling 400 g and 600 g, respectively. However, the patient found the activated charcoal extremely unpalatable. 4 Multiple dose activated charcoal intestinal dialysis (MDACID) has been recently advocated for use in a wide range of poisonings. The technique takes advantage of the large surface area of the small intestine to eliminate drugs and metabolites, over several days if necessary. The pharmacokinetics of digoxin toxicity in chronic renal failure make intest inal dialysis an appropriate method of treatment but the realisation of the true potential of this technique awaits a more palatable absorbent or formulation.

Lanoxitest - digoxin radio-immunoassay kit

1972 ◽  
Vol 10 (1) ◽  
pp. 1.2-3
Keyword(s):  
Renal Failure ◽  
Digoxin Concentration ◽  
The Elderly ◽  
Underlying Disease ◽  
Digoxin Toxicity ◽  
Toxic Effects ◽  
Plasma Digoxin ◽  
Plasma Digoxin Concentration ◽  
Radio Immunoassay

Digoxin toxicity is a relatively common problem.1 It occurs often in the elderly, in patients with renal failure and in those with hypokalaemia; in all these the diagnosis is particularly difficult as many of the indications of toxicity, such as anorexia, nausea, vomiting and most of the arrhythmias are apt to be caused by the underlying disease. The problem can be resolved in normokalaemic patients by knowing the plasma digoxin concentration, for in these patients there is a good correlation between the concentration of digoxin in the plasma and the development of therapeutic or toxic effects.

An Assessment of Digoxin Radio-Immunoassay

1973 ◽  
Vol 18 (3) ◽  
pp. 69-74 ◽  
Author(s):  
B. Whiting ◽  
D. J. Sumner ◽  
A. Goldberg
Keyword(s):  
Renal Failure ◽  
Plasma Volume ◽  
Attempted Suicide ◽  
Digoxin Concentration ◽  
Dosage Schedule ◽  
Plasma Digoxin ◽  
Plasma Digoxin Concentration ◽  
Radio Immunoassay ◽  
Digoxin Poisoning

Using a commercially available digoxin radio-immunoassay kit, an accuracy of the order of ±10 per cent has been achieved. Precision could be improved by increasing the ratio (volume of plasma/volume of radioactive digoxin). The assay permitted separation of clinically toxic and non-toxic patients with plasma digoxin values of 3.5±0.6 (S.D.) ng. per ml. and 1.4±0.6 ng. per ml. respectively (p <0.001). A correlation between blood urea and plasma digoxin concentration was demonstrated (r=0.57, p <0.001). The assay was particularly useful in the confirmation and follow-up of suspected digoxin poisoning in attempted suicide, and in renal failure to arrive at a modified digoxin dosage schedule.

Peak Plasma Digoxin Concentration and Cardiotoxicity

1978 ◽  
pp. 273-283 ◽  
Author(s):  
B. F. Johnson ◽  
D. J. Chapple ◽  
R. Hughes ◽  
J. LaBrooy ◽  
I. Smith
Keyword(s):  
Peak Plasma ◽  
Digoxin Concentration ◽  
Plasma Digoxin ◽  
Plasma Digoxin Concentration

Effect of Quinine on Plasma Digoxin Concentration and Renal Digoxin Clearance

2009 ◽  
Vol 218 (2) ◽  
pp. 229-232 ◽  
Author(s):  
KNUD ERIK PEDERSEN ◽  
JAN LYSGAARD MADSEN ◽  
NIELS ANDERS KLITGAARD ◽  
KAREN KJAER ◽  
STEFFEN HVIDT
Keyword(s):  
Digoxin Concentration ◽  
Plasma Digoxin ◽  
Plasma Digoxin Concentration ◽  
Digoxin Clearance
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