The long-term effect of verapamil on plasma digoxin concentration and renal digoxin clearance in healthy subjects

1982 ◽  
Vol 22 (2) ◽  
pp. 123-127 ◽  
Author(s):  
K. E. Pedersen ◽  
A. Dorph-Pedersen ◽  
S. Hvidt ◽  
N. A. Klitgaard ◽  
K. K. Pedersen
Keyword(s):  
Healthy Subjects ◽  
Digoxin Concentration ◽  
Term Effect ◽  
Plasma Digoxin ◽  
Long Term Effect ◽  
Plasma Digoxin Concentration ◽  
Digoxin Clearance

Effect of Quinine on Plasma Digoxin Concentration and Renal Digoxin Clearance

2009 ◽  
Vol 218 (2) ◽  
pp. 229-232 ◽  
Author(s):  
KNUD ERIK PEDERSEN ◽  
JAN LYSGAARD MADSEN ◽  
NIELS ANDERS KLITGAARD ◽  
KAREN KJAER ◽  
STEFFEN HVIDT
Keyword(s):  
Digoxin Concentration ◽  
Plasma Digoxin ◽  
Plasma Digoxin Concentration ◽  
Digoxin Clearance

Digoxin and Cimetidine: Investigation of the Potential for a Drug Interaction

1985 ◽  
Vol 4 (4) ◽  
pp. 391-399 ◽  
Author(s):  
P. Crome ◽  
B. Curl ◽  
D. Holt ◽  
G.N. Volans ◽  
P.N. Bennett ◽  
...  
Keyword(s):  
Healthy Volunteer ◽  
Peak Plasma ◽  
Digoxin Concentration ◽  
Pharmacokinetic Interaction ◽  
Repeated Dose ◽  
Average Increase ◽  
Plasma Digoxin ◽  
Plasma Digoxin Concentration ◽  
Dose Study

1 The potential for a pharmacokinetic interaction between digoxin and cimetidine was investigated in a series of studies. 2 In a single-dose cross-over study in healthy volunteer subjects cimetidine increased the area under the plasma digoxin concentration curve and the peak plasma digoxin concentration. 3 In a repeated-dose study in healthy volunteer subjects taking digoxin 0.25 mg daily, co-administration of cimetidine resulted in an average increase in plasma digoxin concentration of 0.15 ng/ml. 4 In a repeated-dose study in healthy volunteer subjects taking digoxin 0.5 mg daily, co-administration of cimetidine resulted in an average increase in plasma digoxin concentration of 0.19 ng/ml. 5 In a repeated-dose study in patients receiving long-term digoxin therapy for atrial fibrillation co-administration of cimetidine had no significant effect on plasma digoxin concentrations. 6 We have shown that co-administration of cimetidine and digoxin in volunteer subjects causes a statistically significant but small increase in plasma digoxin concentration but no such increase was found in patients. We conclude that it is doubtful that this interaction is of any clinical significance.

A long-term effect of subliminally presented words

2010 ◽  
Author(s):  
Andreas T. Breuer ◽  
Michael E. J. Masson ◽  
Glen E. Bodner
Keyword(s):  
Term Effect ◽  
Long Term Effect
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