scholarly journals Clear cell urothelial carcinoma of the urinary bladder - a rare pathological entity. A case report and a systematic review of the literature

2019 ◽  
Author(s):  
Ioana Mihai ◽  
Sorina Taban ◽  
Alin Cumpanas ◽  
Emilian Gh. Olteanu ◽  
Mihaela Iacob ◽  
...  
Keyword(s):  
Systematic Review ◽  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Clear Cell ◽  
Citation Index ◽  
Urinary Bladder Cancer ◽  
Review Of The Literature ◽  
Cell Variant ◽  
Clear Cell Variant ◽  
Common Histological Type

The most common histological type of urinary bladder cancer is urothelial carcinoma (UC). In contrast, the clear cell variant of urothelial carcinoma (CCUC) is quite a rare neoplasm. In this study, we report a case of an 81-year-old male, presenting with gross hematuria and acute urinary retention, which was subsequently diagnosed with CCUC at our pathology department. Furthermore, we provide a short systematic review of the literature (PubMed, Scopus, Science Citation Index) for this rare histopathological entity and a brief discussion about its morphological and immunohistochemical (IHC) characteristics.

scholarly journals Clear-cell variant urothelial carcinoma of the bladder: a case report and review of the literature

Rare Tumors ◽  
2012 ◽  
Vol 4 (4) ◽  
pp. 153-155 ◽  
Author(s):  
Mario W. Kramer ◽  
Mahmoud Abbas ◽  
Stefanie Pertschy ◽  
Jan Ulrich Becker ◽  
Hans-Heinrich Kreipe ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Clear Cell ◽  
Transitional Cell ◽  
Tumor Burden ◽  
Initial Diagnosis ◽  
Review Of The Literature ◽  
Peritoneal Carcinosis ◽  
Carcinoma Of The Bladder ◽  
Cell Variant ◽  
Clear Cell Variant

Clear cell variants of transitional cell carcinomas (TCC) of the bladder are extremely rare tumors. Only 6 cases have been reported until now. We report of a 67 year old man who presented with fast growing tumor disease. While initial diagnosis showed localized bladder tumor, final histopathology revealed pT4, G3, L1 urothelial carcinoma with clear cell differentiation. No more than 14 weeks after initial diagnosis the patient died from multi-organ failure after unsuccessful salvage laparotomy which showed massive tumor burden within the pelvis and peritoneal carcinosis. This case demonstrated an extremely fast tumor growth. Therefore, patients with clear cell urothelial carcinoma should be treated vigorously and without time delay. We present a case of clear cell variant of TCC which exhibited an extremely aggressive behavior. To our knowledge this is the fifth report of this rare disease.

Urothelial carcinoma (clear cell variant) diagnosed with useful immunohistochemistry stain

2006 ◽  
Vol 13 (11) ◽  
pp. 1448-1450 ◽  
Author(s):  
RYO YAMASHITA ◽  
RAIZOU YAMAGUCHI ◽  
KEIJI YUEN ◽  
MASASHI NIWAKAWA ◽  
KENICHI TOBISU
Keyword(s):  
Urothelial Carcinoma ◽  
Clear Cell ◽  
Cell Variant ◽  
Immunohistochemistry Stain ◽  
Clear Cell Variant

Clear cell variant of calcifying epithelial odontogenic tumor: Case report and review of the literature

Head & Neck ◽  
1994 ◽  
Vol 16 (3) ◽  
pp. 272-277 ◽  
Author(s):  
M. John Hicks ◽  
Catherine M. Flaitz ◽  
Mark E. K. Wong ◽  
R. Keith McDaniel ◽  
Philip T. Cagle
Keyword(s):  
Case Report ◽  
Clear Cell ◽  
Odontogenic Tumor ◽  
Review Of The Literature ◽  
Calcifying Epithelial Odontogenic Tumor ◽  
Cell Variant ◽  
Clear Cell Variant ◽  
Epithelial Odontogenic Tumor

scholarly journals Clear cell variant, urothelial carcinoma of ureter: A rare entity

2020 ◽  
Vol 33 ◽  
pp. 101331
Author(s):  
Anuj Mahajan ◽  
Prashanth Adiga ◽  
Aaron Fernandes
Keyword(s):  
Urothelial Carcinoma ◽  
Clear Cell ◽  
Rare Entity ◽  
Cell Variant ◽  
Clear Cell Variant

scholarly journals Clear cell urothelial carcinoma of the urinary bladder: a case report and review of the literature

2014 ◽  
Vol 8 (1) ◽  
Author(s):  
Virginia M Knez ◽  
Willis Barrow ◽  
M Scott Lucia ◽  
Shandra Wilson ◽  
Francisco G La Rosa
Keyword(s):  
Case Report ◽  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Clear Cell ◽  
Review Of The Literature

scholarly journals Primary clear-cell urothelial carcinoma of urinary bladder: a not-so-clear entity with review of literature

2019 ◽  
Vol 12 (10) ◽  
pp. e231192 ◽  
Author(s):  
Lalit Kumar ◽  
Anubhav Narwal ◽  
Manoj Kumar ◽  
Seema Kaushal
Keyword(s):  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Urothelial Cancer ◽  
Clear Cell ◽  
Muscularis Propria ◽  
Urinary Bladder Cancer ◽  
Review Of Literature ◽  
Unusual Variant ◽  
Urothelial Tumours

Primary clear-cell urothelial carcinoma (CCUC) is an uncommon type of urothelial cancer with only 16 cases reported in published literature. Due to the rarity of the tumour, its clinical and prognostic values have not been clearly understood. We present one such rare clinical diagnosis in a 60-year- old man who underwent radical cystectomy (RC) with ileal conduit for urinary bladder cancer. Histopathology showed features of high-grade CCUC infiltrating the muscularis propria. Immunohistochemistry revealed diffuse immunopositivity of pan cytokeratin (CK), GATA3, P40, CK7 but was immunonegative for CD10 and vimentin. Our patient expired 4 months after diagnosis. CCUC has recently been included in the WHO 2016 classification of urothelial tumours. Most of the patients present with poor prognosis. Accurate diagnosis and recognition of this unusual variant are essential for better patient management and prognosis. Early RC seems to be the preferred way of management.

Clear Cell Variant of Solid Pseudopapillary Neoplasm of the Pancreas: A Report of a Rare Variant and Review of the Literature

2019 ◽  
Vol 27 (5) ◽  
pp. 535-540
Author(s):  
Cristina Costales ◽  
Arjun Mehta ◽  
Sujit Kulkarni ◽  
Brent K. Larson
Keyword(s):  
Rare Variant ◽  
Clear Cell ◽  
Cell Tumor ◽  
Solid Pseudopapillary Neoplasm ◽  
Review Of The Literature ◽  
Pathologic Features ◽  
Cell Variant ◽  
Important Variant ◽  
Clear Cell Variant

The clear cell variant of solid pseudopapillary neoplasm (ccSPN) of the pancreas was first described in 2006. In this article, we report a case of this rare variant and review the few published reports. Both the current and previous reports show that ccSPN has several morphologic differences from conventional SPN, including clear vacuoles, fewer pseudopapillary formations, more solid/diffuse architecture, less hemorrhage, and fewer cholesterol clefts. Some of these features peculiar to ccSPN, such as solid/diffuse architecture, have been proposed to suggest aggressive behavior, though reports of ccSPN are rare and often have limited clinical follow-up. ccSPN also appears to occur more frequently in males than conventional SPNs. These clinical and pathologic features lead to unique set of differential diagnostic considerations for ccSPN, including metastatic renal cell carcinoma, perivascular epithelial cell tumor, and clear cell variants of other carcinomas. These unique features, atypical differential, and uncertain prognostic ramifications all make ccSPN an important variant to be aware of and report.

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