scholarly journals  Influence of Lippia citriodora verbascoside on growth performance, antioxidant status, and serum immunoglobulins content in piglets

2012 ◽  
Vol 57 (No. 7) ◽  
pp. 312-322 ◽  
Author(s):  
G. Pastorelli ◽  
R. Rossi ◽  
C. Corino
Keyword(s):  
Growth Performance ◽  
Plant Extract ◽  
Antioxidant Status ◽  
Density Lipoprotein ◽  
Feed Additives ◽  
Lipoprotein Cholesterol ◽  
Feed Consumption ◽  
Reactive Oxygen Metabolites ◽  
Lippia Citriodora ◽  
Over Time

Phytogenic feed additives are used in animal feeding to improve livestock performance. The aim of this study was to determine whether a dietary plant extract from Lippia citriodora, standardized for verbascoside, can modify various immunological, oxidative, and biochemical serum parameters in weaned piglets. A total of 144 piglets, half female and half barrows (7.99 ± 1.40 kg BW), were allocated to three dietary treatments with six replicates per treatment (pens of 8 piglets each). Piglets were supplemented with the following levels of plant extract standardized for verbascoside: 0 (CON = control group), 5 (LV = low verbascoside group), or 10 (HV = high verbascoside group) mg/kg of diet for 56 days. Body weight (BW) and feed consumption were recorded at days 0 and 56 to determine the average daily gain and gain : feed. Twelve piglets from each treatment were randomly selected, and blood was collected by anterior vena cava puncture on days 0, 14, and 56 for glucose, triglycerides, cholesterol, urea, and oxidative status, and on days 0 and 56 for IgG and IgA concentrations. The HV group grew more (P < 0.05) than the CON and LV groups. No significant differences were observed for any of the biochemical parameters between the groups; urea, high density lipoprotein cholesterol, total cholesterol, and low density lipoprotein cholesterol increased significantly over time. Reactive oxygen metabolites (ROM) showed significant time, time × treatment, and treatment effects (P < 0.001). Both serum Igs increased (P < 0.005, P < 0.001 for IgG and IgA respectively) over time in all groups; treatment (P < 0.05), and time × treatment (P = 0.056) effects were found for serum IgA concentration. The Lippia citriodora verbascoside positively influenced antioxidant status and IgA content with a tendential effect on growth performance.  

Effect of dietary Lippia citriodora extract on reproductive and productive performance and plasma biochemical parameters in rabbit does

2017 ◽  
Vol 57 (1) ◽  
pp. 65 ◽  
Author(s):  
D. Casamassima ◽  
M. Palazzo ◽  
F. Vizzarri ◽  
L. Ondruska ◽  
P. Massanyi ◽  
...  
Keyword(s):  
Dietary Supplement ◽  
Biochemical Parameters ◽  
Density Lipoprotein ◽  
Dose Effect ◽  
Lipoprotein Cholesterol ◽  
Daily Weight Gain ◽  
Reactive Oxygen Metabolites ◽  
Adaptation Period ◽  
Natural Extract ◽  
Lippia Citriodora

Two doses of natural extract from Lippia citriodora (titrated in verbascoside) were assessed in New Zealand White rabbit does evaluating selected reproductive, productive and plasma biochemical parameters. After 1 week of adaptation period, the trial on 45 rabbit does for three consecutive reproductive cycles was conducted; does were divided into three groups of 15 animals each, homogenous by age (1 year ± 2 weeks), bodyweight (4.77 ± 0.21 kg) and parity (2 ± 1). A control group (CON) did not receive the dietary supplement in the feed and the other two groups received 1 g of natural extract supplement in the feed (5 mg verbascoside/kg feed; LNE) and 2 g of natural extract (10 mg verbascoside/kg feed; HNE). The use of a dietary NE supplement improved kit bodyweight at weaning (934 vs 1104 g; P < 0.001), and average daily weight gain from birth to weaning (24.7 vs 29.7 g/day; P < 0.001), with no NE dose effect. In the LNE and HNE groups serum triglycerides, total cholesterol, low density lipoprotein cholesterol, bilirubin, and activities of alkaline phosphatase, alanine aminotransferase (P < 0.05) and aspartate aminotransferase (P < 0.01) decreased and high density lipoprotein cholesterol (P < 0.01) increased, according to the cycle effect. The dietary supplement also improved blood oxidative status markers in the experimental groups due to an increase in the concentrations of plasma vitamin A and E (P < 0.01) and a decrease in plasma reactive oxygen metabolites and thiobarbituric acid reactive substances values (P < 0.01). In conclusion, the dietary Lippia NE supplement improved selected productive and reproductive parameters and the animal welfare of does, expressed by a general improvement of blood profile, with no effect of the dose.

scholarly journals Phytogenic compounds do not interfere physiological parameters and growth performances on two Indonesian local breeds of ducks

2019 ◽  
Vol 12 (11) ◽  
pp. 1689-1697
Author(s):  
Ismoyowati Ismoyowati ◽  
Diana Indrasanti ◽  
Sigit Mugiyono ◽  
Mulyoto Pangestu
Keyword(s):  
Lipid Profile ◽  
Growth Performance ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Physiological Parameters ◽  
Feed Additives ◽  
Feed Consumption ◽  
Muscovy Duck ◽  
Blood Lipid Profile ◽  
Growth Performances

Aim: The present study was to investigate the interaction between duck's breed and phytogenic compounds as feed additives in the diet on blood lipid and hematological profile, welfare, and growth performance. Materials and Methods: A total of 200 male day-old local breed ducks (Tegal and Muscovy ducks) were used in this experiment. The first factor was duck breed and the second factor was different phytogenic compounds supplementation in the diet: Garlic, turmeric, ginger, and kencur, at 3% each. The observed variables were the blood lipid profiles comprise high-density lipoprotein (HDL), low-density lipoprotein, cholesterol total, triglyceride, blood parameters, welfare (heterophil/ lymphocyte [H/L] ratio), and growth performances (feed consumption, body weight gain, feed conversion ratio, and carcass percentage). Results: The interaction between breed of ducks and phytogenic compounds had a significant effect on blood triglyceride, but no significant effect on the blood lipid profile, hematological parameters, and growth performances. While, phytogenic compounds in the diet had significant effects on the blood lipid profile, heterophil (H), lymphocyte (L), and H/L ratio of ducks. The breed factors affected HDL and growth performances. Muscovy duck had a higher HDL and growth performance compare to Tegal duck. Among those, garlic most effectively reduced triglyceride level in Tegal duck. Conclusion: Phytogenic compounds 3% do not have a negative effect on the physiological parameters of ducks increase ducks welfare (H/L ratio), so it does not affect the growth performances of ducks. Muscovy duck had higher growth performances than Tegal ducks.

scholarly journals Effects of Lippia citriodora Leaf Extract on Lipid and Oxidative Blood Profile of Volunteers with Hypercholesterolemia: A Preliminary Study

Antioxidants ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 521
Author(s):  
Antonella Angiolillo ◽  
Deborah Leccese ◽  
Marisa Palazzo ◽  
Francesco Vizzarri ◽  
Donato Casamassima ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Leaf Extract ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Plasma Vitamin ◽  
Reactive Oxygen Metabolites ◽  
Blood Profile ◽  
Antioxidant Power ◽  
Lippia Citriodora ◽  
Preliminary Study

Lippia citriodora is a plant traditionally used for its anti-inflammatory, antioxidant and antispasmodic effects, as well as for additional biological activities proven in cell culture, animal studies and a small number of human clinical trials. The plant has also shown a marked improvement in blood lipid profile in some animal species. In the present preliminary study, we investigated the effect of a leaf extract on lipid and oxidative blood profile of hypercholesterolemic volunteers. Twelve adults received Lippia citriodora extract caps, containing 23% phenylpropanoids, (100 mg, once a day) for 16 weeks. Selected blood lipids and plasma oxidative markers were measured at baseline and after 4, 8 and 16 weeks of treatment. Compared with baseline, total cholesterol levels significantly decreased and high-density lipoprotein cholesterol increased, while low-density lipoprotein cholesterol and triglycerides showed only a downward trend. Oxidative status was improved due to a decrease in the concentration of total oxidant status, reactive oxygen metabolites and malondialdehyde, and a significant increase in ferric reducing ability of plasma, vitamin A and vitamin E. These preliminary results suggest that dietary supplementation with Lippia citriodora extract can improve the lipid profile, enhance blood antioxidant power, and could be a valuable natural compound for the management of human hypercholesterolemia.

Abstract P018: Calibration of Analytes Over Twenty-Five Years in the Atherosclerosis Risk in Communities Study

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Christina M Parrinello ◽  
Morgan E Grams ◽  
David Couper ◽  
Christie M Ballantyne ◽  
Ron C Hoogeveen ◽  
...  
Keyword(s):  
Uric Acid ◽  
Troponin T ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Sensitivity ◽  
Lipoprotein Cholesterol ◽  
Gamma Glutamyl Transpeptidase ◽  
Deming Regression ◽  
The Impact ◽  
Over Time

Background: Comparability of laboratory measures over time is important for studies of disease prevalence and progression. While a small amount of bias may seem negligible on an individual level, it can result in substantial misclassification of disease in the population. We conducted a calibration study of important biomarkers across five study visits (25 years) in ARIC. Methods: We re-measured 15 analytes in 200 blood samples to calibrate original measurements at each time point using Bland-Altman plots and Deming regression. We also assessed the impact of calibration on the prevalence of chronic kidney disease (CKD), defined by estimated glomerular filtration rate using creatinine (eGFRcr), and on trends over time. Results: Assays in samples frozen 12-27 years were highly correlated with original values (median r=0.95) after removing outliers (median 4% of values). The range of bias (% difference in means) across visits for each original analyte compared to its reference were: creatinine: 13-49%; uric acid: 3-24%; C-reactive protein: 3-9%; total cholesterol: 1-6%; high density lipoprotein cholesterol: 4-8% (but new methods differed); low density lipoprotein cholesterol: 1-5%; triglycerides: 2-4%; glucose: 1-4%; N-terminal prohormone of brain natriuretic peptide: 2-12%; high sensitivity cardiac troponin T: 1-9%; alanine transaminase (ALT): 21%; aspartate transaminase (AST): 17%; gamma glutamyl transpeptidase: 0.2%; ß2-microglobulin: 1%; beta-trace protein: 13%. Four analytes met calibration criteria: creatinine, uric acid, ALT and AST. The impact on CKD prevalence was substantial and similar to previous statistical calibration (22% uncalibrated, 1.9% previously and 1.3% current laboratory calibration). Trends in eGFRcr over time were better aligned after calibration ( Figure ). Conclusions: Repeat assay of samples shows high correlation with original values. Calibration enables application of absolute cutoffs (required for defining CKD and other conditions) and improves longitudinal analyses.

Effects of dietary n-6/n-3 polyunsaturated fatty acids ratio on growth performance, apparent digestibility, blood lipid profiles, fecal microbiota, and meat quality in finishing pigs

2020 ◽  
Vol 100 (2) ◽  
pp. 272-281
Author(s):  
Hao Yang Sun ◽  
Hyeok Min Yun ◽  
In Ho Kim
Keyword(s):  
Fish Oil ◽  
Growth Performance ◽  
Meat Quality ◽  
Linseed Oil ◽  
Average Daily Gain ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Lipid Profiles ◽  
Lipoprotein Cholesterol ◽  
Finishing Pigs

The effects of dietary omega-6 (n-6) to omega-3 (n-3) polyunsaturated fatty acid (PUFA) ratios on growth performance, digestibility, blood lipid profiles, fecal microbial counts, and meat quality in finishing pigs were examined by using linseed and fish oil. A total of 140 crossbred finishing pigs [(Landrace × Yorkshire) × Duroc] were used in a 10 wk trial. Pigs were blocked based on body weight (BW) and sex and randomly allotted to four dietary treatments formulated to have n-6/n-3 ratios of 5/1, 10/1, 15/1, and 17/1 (control). Throughout the experiment, BW, average daily gain, and average daily feed intake were significantly (P < 0.05) increased with a decreased ratio of n-6/n-3 PUFA. Energy digestibility and fecal Lactobacillus count showed a linear (P < 0.05) increase in week 10. The high-density lipoprotein cholesterol and blood triglyceride concentrations increased (P < 0.1) during week 10. However, low-density lipoprotein cholesterol was reduced (P < 0.05) linearly during week 5 and week 10 with a reduction in dietary n-6/n-3 ratio. This study provides a basis for future research on altering n-6/n-3 ratio by using linseed oil and refined fish oil in finishing pigs.

Comparative effects of powder, aqueous and methanolic extracts of purslane (Portulaca oleracea L.) on growth performance, antioxidant status, abdominal fat deposition and plasma lipids in broiler chickens

2019 ◽  
Vol 59 (1) ◽  
pp. 89 ◽  
Author(s):  
Mahmood Habibian ◽  
Ghorbanali Sadeghi ◽  
Ahmad Karimi
Keyword(s):  
Superoxide Dismutase ◽  
Glutathione Peroxidase ◽  
Plasma Levels ◽  
Broiler Chickens ◽  
Antioxidant Status ◽  
Density Lipoprotein ◽  
Abdominal Fat ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Dietary Treatments

This study was performed to evaluate the comparative effects of dietary supplementation of dried purslane powder (PP), purslane aqueous extract (PAE) and purslane methanolic extract (PME) on performance, antioxidant status, carcass traits and selected plasma lipid parameters in broiler chickens. In total, 420 1-day-old male broiler chicks were divided into seven treatments for 49 days as follows: control (basal diet), basal diets plus 1500 or 3000 mg/kg of PP (PP1500 and PP3000 respectively), basal diets plus 150 or 300 mg/kg of PAE (PAE150 and PAE300 respectively) and basal diets plus 150 or 300 mg/kg of PME (PME150 and PME300 respectively). During the total period of the experiment (0–49 days of the experiment), birds receiving the PP3000 diet had higher (P &lt; 0.05) bodyweight gain and a lower feed conversion ratio compared with those fed other diets. At 24 and 49 days of the experiment, birds receiving the PP3000 diet showed greater (P &lt; 0.05) plasma and liver activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx), and lower (P &lt; 0.05) plasma and liver levels of malondialdehyde compared with other dietary treatments. Additionally, at 24 days of the experiment, birds receiving the PP3000 diet had a greater (P &lt; 0.05) liver catalase activity than those receiving other dietary treatments. In addition, groups receiving the PP1500, PAE300 or PME300 diets showed greater (P &lt; 0.05) plasma and liver activities of superoxide dismutase, catalase and glutathione peroxidase, as well as lower (P &lt; 0.05) plasma and liver levels of malondialdehyde compared with the control group. At 24 days of the experiment, birds receiving the PP1500 or PP3000 diets showed greater (P &lt; 0.05) jejunal activities of superoxide dismutase, catalase and glutathione peroxidase than other groups. At 49 days of the experiment, birds receiving the PP3000 diet showed greater (P &lt; 0.05) jejunal activities of superoxide dismutase and glutathione peroxidase compared with the control group. Additionally, at both 24 and 49 days of the experiment, groups receiving the PP3000 diet had lower (P &lt; 0.05) jejunal levels of malondialdehyde compared with the control group. At 49 days of the experiment, birds receiving the PP3000 diet had a lower (P &lt; 0.05) relative weight of abdominal fat compared with those receiving the other dietary treatments. Moreover, groups that consumed the PP1500, PAE300 or PME300 diets showed lower (P &lt; 0.05) relative weights of abdominal fat compared with the control group. Groups fed PP, PAE or PME treatments showed lower (P &lt; 0.05) plasma levels of triglycerides, total cholesterol and low-density lipoprotein cholesterol, and higher (P &lt; 0.05) plasma levels of high-density lipoprotein cholesterol than the control group at 24 and 49 days of the experiment, with the most pronounced effects observed in those receiving the PP3000 treatment. In conclusion, PP showed more beneficial effects than PAE and PME, and 3000 mg/kg was the best inclusion level of PP in broiler chicken diets.

scholarly journals Effect of Vitamins A, C, and E Supplementation in the Treatment of Metabolic Syndrome in Albino Rats

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
L. S. Bilbis ◽  
S. A. Muhammad ◽  
Y. Saidu ◽  
Y. Adamu
Keyword(s):  
Metabolic Syndrome ◽  
Antioxidant Status ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Total Antioxidant Status ◽  
Lipoprotein Cholesterol ◽  
Albino Rats ◽  
Low Density Lipoprotein Cholesterol ◽  
Salt Diet ◽  
Total Antioxidant

Obesity and metabolic syndrome increase the risk of cardiovascular morbidity and mortality. Oxidative stress seems to be involved in the path physiology of cardiovascular complications of metabolic syndrome. In this study we investigated the effects of vitamins A, C, and E in the management of metabolic syndrome traits condition in albino rats fed with high salt diet. The rats were placed on 8% NaCl diet for 5 weeks and then supplemented with these vitamins for additional 4 weeks in the presence of salt diet. Supplementation with vitamins significantly (P<0.01) decreased blood pressure of the rats as compared with the control. Supplementation also significantly (P<0.05) reduced serum total cholesterol, triglyceride, low-density lipoprotein cholesterol, and very-low-density lipoprotein cholesterol and increased high-density lipoprotein cholesterol, and total antioxidant status as compared with untreated group. The percentage protection of the supplemented groups against atherogenesis indicated55.50±3.75%. Percentage weight gain indicated significant positive correlation with triglyceride, insulin resistance, and malondialdehyde while total antioxidant status and nitric oxide showed significant negative correlation. Salt diet significantly (P<0.05) induced features of metabolic syndrome. The result, therefore, indicated strong relationship between obesity and metabolic syndrome and underscores the role of these vitamins in the management of metabolic syndrome.

scholarly journals Gene discovery for high-density lipoprotein cholesterol level change over time in prospective family studies

2020 ◽  
Vol 297 ◽  
pp. 102-110
Author(s):  
Mary F. Feitosa ◽  
Kathryn L. Lunetta ◽  
Lihua Wang ◽  
Mary K. Wojczynski ◽  
Candace M. Kammerer ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
Cholesterol Level ◽  
High Density Lipoprotein Cholesterol ◽  
Gene Discovery ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Change Over Time ◽  
Level Change ◽  
Over Time

The Effects of 5-year Etanercept Therapy on Cardiovascular Risk Factors in Patients with Psoriatic Arthritis

2017 ◽  
Vol 44 (9) ◽  
pp. 1362-1368 ◽  
Author(s):  
Rabia Agca ◽  
Maaike Heslinga ◽  
Eva L. Kneepkens ◽  
Carlo van Dongen ◽  
Michael T. Nurmohamed
Keyword(s):  
Risk Factors ◽  
Psoriatic Arthritis ◽  
Disease Activity ◽  
Mixed Model ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Cvd Risk Factors ◽  
Cvd Risk ◽  
Over Time

Objective.To investigate the effects of etanercept (ETN) on lipid metabolism and other known cardiovascular disease (CVD) risk factors in patients with psoriatic arthritis (PsA).Methods.In an observational cohort of 118 consecutive patients with PsA, CVD risk factors were assessed over 5 years. Mixed-model analyses were performed to investigate the effects of ETN therapy on CVD risk factors over time.Results.Disease Activity Score in 28 joints, C-reactive protein (CRP), and erythrocyte sedimentation rate decreased during therapy with ETN. There was an increase in total cholesterol (TC), high-density lipoprotein cholesterol (HDLc), and low-density lipoprotein cholesterol. The TC/HDLc ratio remained unaltered. The apolipoprotein B to apolipoprotein A-I (apoB/apoA-I) ratio decreased significantly. An increase in CRP was associated with an increase in the apoB/apoA-1 ratio.Conclusion.Serum lipid concentrations showed small changes over a 5-year period of ETN therapy and were inversely associated with inflammatory markers. Other CVD risk factors remained stable. The apoB/apoA-1 ratio decreased over time and an increase in disease activity was associated with an increase in this ratio. However, this modest lipid modulation cannot explain the observed beneficial CV effects of ETN, and ETN likely exerts those effects through inflammation-related mechanisms.

Sign in / Sign up

Export Citation Format

Share Document