Human exposure to pollutants and their health endpoints

Author(s):  
Jon Øyvind Odland

The most vulnerable period in a human life is before you are born and in early childhood. A number of reports and publications are now coming out of these studies and this chapter will go into details of some of the the most important studies and their defined health endpoints. Different epidemiological studies in the circumpolar area have shown associations between contaminants and different health outcomes. It is important to note that associations are not the same as causal relationships between exposure to a single substance (or a mix of substances) and an effect. When finding an association between a contaminant and an effect it is important to bear in mind the possibility that the studied substance are proxies for other substances in the mixture of contaminants to which the study population has been exposed – both harmful and beneficial. The effects reported are findings from different circumpolar communities. However, due to differences in genetic composition, socio-cultural practices, local food consumption patterns and exposure mixtures, a finding in one population should not be extrapolated to another population without careful investigation and comparative information.

2021 ◽  
pp. bjsports-2020-103906
Author(s):  
Benjamin Clarsen ◽  
Babette M Pluim ◽  
Víctor Moreno-Pérez ◽  
Xavier Bigard ◽  
Cheri Blauwet ◽  
...  

In 2020, the IOC released a consensus statement that provides overall guidelines for the recording and reporting of epidemiological data on injury and illness in sport. Some aspects of this statement need to be further specified on a sport-by-sport basis. To extend the IOC consensus statement on methods for recording and reporting of epidemiological data on injury and illness in sports and to meet the sport-specific requirements of all cycling disciplines regulated by the Union Cycliste Internationale (UCI). A panel of 20 experts, all with experience in cycling or cycling medicine, participated in the drafting of this cycling-specific extension of the IOC consensus statement. In preparation, panel members were sent the IOC consensus statement, the first draft of this manuscript and a list of topics to be discussed. The expert panel met in July 2020 for a 1-day video conference to discuss the manuscript and specific topics. The final manuscript was developed in an iterative process involving all panel members. This paper extends the IOC consensus statement to provide cycling-specific recommendations on health problem definitions, mode of onset, injury mechanisms and circumstances, diagnosis classifications, exposure, study population characteristics and data collection methods. Recommendations apply to all UCI cycling disciplines, for both able-bodied cyclists and para-cyclists. The recommendations presented in this consensus statement will improve the consistency and accuracy of future epidemiological studies of injury and illness in cycling.


2016 ◽  
Vol 33 (S1) ◽  
pp. S384-S384
Author(s):  
I. Prieto Sánchez ◽  
M.D.L.C. Ramírez Domínguez ◽  
S. Fernández León ◽  
M. Reina Domínguez ◽  
N. Garrido Torres ◽  
...  

IntroductionPatients with anxiety disorders are more vulnerable to develop other comorbid conditions. In particular, large epidemiological studies show a strong association between different anxiety disorders and substance use disorders.ObjectivesTo show the prevalence of major anxiety disorders and the consumption of different substances. As well as the particular characteristics of this dual diagnosis and treatments that have proven more effective.MethodsExhaustive review of all the material published on this topic in the recent years.ConclusionsNearly 24% of patients with anxiety disorder suffer from a comorbid substance disorder use in their lifetime (17.9% diagnosis of alcohol abuse or dependence diagnosis and 11.9% of abuse or dependence on other drugs). Dual patients show a number of distinctive features, such as more frequency in males, family history of alcohol or other substances abuse and behavioral problems, early parental loss among others.Disclosure of interestThe authors have not supplied their declaration of competing interest.


2017 ◽  
Vol 41 (S1) ◽  
pp. s853-s853
Author(s):  
S.A. Haji Seyed Javadi

IntroductionResearches showed comorbidity of sleep disorders and mental disorders.Objectives and aimsThe current study aimed to evaluate depression and anxiety and their relationship with insomnia, nightmare and demographic variables in the medical students of Qazvin University of Medical Sciences in 2015.MethodThe study population included 253 medical students with the age range of 18–35 years. Data were gathered using Beck depression inventory, Kettle anxiety, and insomnia and nightmare questionnaires and were analyzed by proper statistical methods.ResultsAmong the participants, 126 (49.6%) subjects had depression and 108 (42.5%) anxiety. The prevalence of depression and anxiety among the subjects with lower family income was significantly higher (Chi2 = 6.75, P = 0.03 for depression and Х2 = 27.99, P < 0.05 for anxiety). There was a close relationship between depression with sleep-onset difficulty, difficulty in awakening and daily sleep attacks, and also between anxiety with sleep-onset difficulty and daily tiredness (P < 0.05). In addition, there was a close relationship between depression and anxiety with nightmare; 16.2% of the subjects with depression and 26.5% of the ones with anxiety experienced nightmares.ConclusionResults showed a relationship between nightmare, insomnia and level of family income with increasing depression and anxiety in the medical students; hence, due to the importance of medicine in human life, it is necessary to evaluate the mental health of medical students, identify and solve the relative problems such as anxiety, depression and related symptoms such as insomnia and nightmare in them.Disclosure of interestThe author has not supplied his/her declaration of competing interest.


Author(s):  
Sergei Scherbov ◽  
Warren C. Sanderson

Probably the most famous demographic riddle of all time is the one that the Sphinx was said to have posed to travellers outside the Greek city of Thebes: ‘Which creature walks on four legs in the morning, two at noon, and three in the evening?’ Unfortunate travellers who could not answer the riddle correctly were immediately devoured. Oedipus, fresh from killing his father, was the first to have got the answer right. The correct answer was ‘humans’. People crawl on their hands and knees as infants, walk on two feet in adulthood, and walk with a cane in old age. We easily recognize the three ages of humans. Humans are born dependent on the care of others. As they grow, their capacities and productivities generally increase, but eventually these reach a peak. After a while, capacities and productivities decline and, eventually, if they are lucky enough to survive, people become elderly, often again requiring transfers and care from others. The human life cycle is the basis of all studies of population ageing, and so we cannot begin to study population ageing without first answering the Sphinx’s riddle. However, answering the Sphinx’s riddle is not enough to get us started on a study of population ageing. We must take two more steps before we begin. First, we must recognize that not all people age at the same rate. As seen in Chapter 5, nowadays more educated people tend to have longer life expectancies than less educated people. Second, we must realize that there is no natural generalization of the Sphinx’s riddle to whole populations. Populations cannot be categorized into the stages of infancy, adulthood, and old age. Indeed, if the Sphinx was reborn today, we might find her sitting near another city and posing an equally perplexing riddle, one especially relevant for our times: ‘What can grow younger as it grows older?’ Answering this riddle correctly is the central challenge of this chapter and the key to understanding population ageing in the twenty-first century.


Author(s):  
David Columb ◽  
Mark D Griffiths ◽  
Colin O’Gara

Objectives The aim of this study was to carry out the first ever study of gaming characteristics of individuals engaging in online gaming in Ireland and to ascertain whether features of gaming disorder are present in this population. Methods An online survey (comprising 21 questions – 3 demographic questions and 18 questions related to gaming and gaming disorder) was distributed on numerous Irish online gaming forums and Irish online gaming communities. Participants were self-selected and invited to compete the online survey containing questions related to gaming behaviours (age of onset, hours played on weekdays/weekends, type of device used), mobile gaming, motives for online gaming, use of microtransactions, engagement in esports, and a screening tool for the presence of gaming disorder. Results A total of 166 participants engaged in the online survey. Among this study population of regular gamers in Ireland, 2.4% of the study population were classified as having gaming disorder, with up to 5.4% showing some evidence of disordered gaming. The main motivation for online gaming in the non-disordered gaming group was recreation (13.3, sd = 2.7) but only the fourth main motivation in the disordered gaming group behind competition (16.3, sd = 3.7), escape (16.2, sd = 4.3), and coping (15.1, sd = 3.7). Increased hours of gameplay on weekdays and weekends were noted in the disordered gaming group compared to non-disordered gamers. Conclusions A small percentage of gamers in Ireland demonstrate disordered gaming characteristics and gaming disorder, consistent with data from other international studies. Epidemiological studies are required in Ireland to enhance our knowledge of this disorder.


Author(s):  
Lee Artz

Cultural studies seeks to understand and explain how culture relates to the larger society and draws on social theory, philosophy, history, linguistics, communication, semiotics, media studies, and more to assess and evaluate mass media and everyday cultural practices. Since its inception in 1960s Britain, cultural studies has had recognizable and recurring interactions with Marxism, most clearly in culturalist renderings along a spectrum of tensions with political economy approaches. Marxist traditions and inflections appear in the seminal works of Raymond Williams and E. P. Thompson, work on the culture industry inspired by the Frankfurt School in 1930s Germany, challenges by Stuart Hall and others to the structuralist theories of Louis Althusser, and writings on consciousness and social change by Georg Lukács. Perhaps the most pronounced indication of Marxist influences on cultural studies appears in the multiple and diverse interpretations of Antonio Gramsci’s concept of hegemony. Cultural studies, including critical theory, has been invigorated by Marxism, even as a recurring critique of economic determinism appears in most investigations and analyses of cultural practices. Marxism has no authoritative definition or application. Nonetheless, Marxism insists on materialism as the precondition for human life and development, opposing various idealist conceptions whether religious or philosophical that posit magical, suprahuman interventions that shape humanity or assertions of consciousness, creative genius, or timeless universals that supersede any particular historical conjuncture. Second, Marxism finds material reality, including all forms of human society and culture, to be historical phenomenon. Humans are framed by their conditions, and in turn, have agency to make social changing using material, knowledge, and possibilities within concrete historical conditions. For Marxists, capitalist society can best be historically and materially understood as social relations of production of society based on labor power and capitalist private ownership of the means of production. Wages paid labor are less than the value of goods and services produced. Capitalist withhold their profits from the value of goods and services produced. Such social relations organize individuals and groups into describable and manifest social classes, that are diverse and unstable but have contradictory interests and experiences. To maintain this social order and its rule, capitalists offer material adjustments, political rewards, and cultural activities that complement the social arrangements to maintain and adjust the dominant social order. Thus, for Marxists, ideologies arise in uneasy tandem with social relations of power. Ideas and practices appear and are constructed, distributed, and lived across society. Dominant ideologies parallel and refract conflictual social relations of power. Ideologies attune to transforming existing social relations may express countervailing views, values, and expectations. In sum, Marxist historical materialism finds that culture is a social product, social tool, and social process resulting from the construction and use by social groups with diverse social experiences and identities, including gender, race, social class, and more. Cultures have remarkably contradictory and hybrid elements creatively assembled from materially present social contradictions in unequal societies, ranging from reinforcement to resistance against constantly adjusting social relations of power. Five elements appear in most Marxist renditions on culture: materialism, the primacy of historical conjunctures, labor and social class, ideologies refracting social relations, and social change resulting from competing social and political interests.


Toxics ◽  
2019 ◽  
Vol 7 (2) ◽  
pp. 21 ◽  
Author(s):  
Yu Wang ◽  
Hongkai Zhu ◽  
Kurunthachalam Kannan

Phthalates (diesters of phthalic acid) are widely used as plasticizers and additives in many consumer products. Laboratory animal studies have reported the endocrine-disrupting and reproductive effects of phthalates, and human exposure to this class of chemicals is a concern. Several phthalates have been recognized as substances of high concern. Human exposure to phthalates occurs mainly via dietary sources, dermal absorption, and air inhalation. Phthalates are excreted as conjugated monoesters in urine, and some phthalates, such as di-2-ethylhexyl phthalate (DEHP), undergo secondary metabolism, including oxidative transformation, prior to urinary excretion. The occurrence of phthalates and their metabolites in urine, serum, breast milk, and semen has been widely reported. Urine has been the preferred matrix in human biomonitoring studies, and concentrations on the order of several tens to hundreds of nanograms per milliliter have been reported for several phthalate metabolites. Metabolites of diethyl phthalate (DEP), dibutyl- (DBP) and diisobutyl- (DiBP) phthalates, and DEHP were the most abundant compounds measured in urine. Temporal trends in phthalate exposures varied among countries. In the United States (US), DEHP exposure has declined since 2005, whereas DiNP exposure has increased. In China, DEHP exposure has increased since 2000. For many phthalates, exposures in children are higher than those in adults. Human epidemiological studies have shown a significant association between phthalate exposures and adverse reproductive outcomes in women and men, type II diabetes and insulin resistance, overweight/obesity, allergy, and asthma. This review compiles biomonitoring studies of phthalates and exposure doses to assess health risks from phthalate exposures in populations across the globe.


2011 ◽  
Vol 38 (6) ◽  
pp. 1113-1122 ◽  
Author(s):  
FREDERICK WOLFE ◽  
DANIEL J. CLAUW ◽  
MARY-ANN FITZCHARLES ◽  
DON L. GOLDENBERG ◽  
WINFRIED HÄUSER ◽  
...  

Objective.To develop a fibromyalgia (FM) survey questionnaire for epidemiologic and clinical studies using a modification of the 2010 American College of Rheumatology Preliminary Diagnostic Criteria for Fibromyalgia (ACR 2010). We also created a new FM symptom scale to further characterize FM severity.Methods.The ACR 2010 consists of 2 scales, the Widespread Pain Index (WPI) and the Symptom Severity (SS) scale. We modified these ACR 2010 criteria by eliminating the physician’s estimate of the extent of somatic symptoms and substituting the sum of 3 specific self-reported symptoms. We also created a 0–31 FM Symptom scale (FS) by adding the WPI to the modified SS scale. We administered the questionnaire to 729 patients previously diagnosed with FM, 845 with osteoarthritis (OA) or with other noninflammatory rheumatic conditions, 439 with systemic lupus erythematosus (SLE), and 5210 with rheumatoid arthritis (RA).Results.The modified ACR 2010 criteria were satisfied by 60% with a prior diagnosis of FM, 21.1% with RA, 16.8% with OA, and 36.7% with SLE. The criteria properly identified diagnostic groups based on FM severity variables. An FS score ≥ 13 best separated criteria+ and criteria− patients, classifying 93.0% correctly, with a sensitivity of 96.6% and a specificity of 91.8% in the study population.Conclusion.A modification to the ACR 2010 criteria will allow their use in epidemiologic and clinical studies without the requirement for an examiner. The criteria are simple to use and administer, but they are not to be used for self-diagnosis. The FS may have wide utility beyond the bounds of FM, including substitution for widespread pain in epidemiological studies.


2014 ◽  
Vol 112 (10) ◽  
pp. 1644-1653 ◽  
Author(s):  
Michael J. Orlich ◽  
Karen Jaceldo-Siegl ◽  
Joan Sabaté ◽  
Jing Fan ◽  
Pramil N. Singh ◽  
...  

Vegetarian dietary patterns have been reported to be associated with a number of favourable health outcomes in epidemiological studies, including the Adventist Health Study 2 (AHS-2). Such dietary patterns may vary and need further characterisation regarding foods consumed. The aims of the present study were to characterise and compare the food consumption patterns of several vegetarian and non-vegetarian diets. Dietary intake was measured using an FFQ among more than 89 000 members of the AHS-2 cohort. Vegetarian dietary patterns were defined a priori, based on the absence of certain animal foods in the diet. Foods were categorised into fifty-eight minor food groups comprising seventeen major food groups. The adjusted mean consumption of each food group for the vegetarian dietary patterns was compared with that for the non-vegetarian dietary pattern. Mean consumption was found to differ significantly across the dietary patterns for all food groups. Increased consumption of many plant foods including fruits, vegetables, avocados, non-fried potatoes, whole grains, legumes, soya foods, nuts and seeds was observed among vegetarians. Conversely, reduced consumption of meats, dairy products, eggs, refined grains, added fats, sweets, snack foods and non-water beverages was observed among vegetarians. Thus, although vegetarian dietary patterns in the AHS-2 have been defined based on the absence of animal foods in the diet, they differ greatly with respect to the consumption of many other food groups. These differences in food consumption patterns may be important in helping to explain the association of vegetarian diets with several important health outcomes.


2006 ◽  
Vol 34 (1) ◽  
pp. 8-15 ◽  
Author(s):  
Lynn M. Morgan

A friend once told me I was wasting my time writing about cross-cultural perspectives on the beginnings of life. “Your work is interesting for its curiosity value,” he said, “but fundamentally worthless. What happens in other cultures is totally irrelevant to what is happening here.” Those were discouraging words, but as I followed the American debates about the beginnings and ends of life, it seemed he was right. Anthropologists have written a great deal about birth and death rites in other societies and about non-western notions of personhood, but to date our findings have had little impact on American policy, ethics, or law. The recognized experts on contentious topics such as abortion and euthanasia tend to come from the fields of philosophy, bioethics, theology, law, and biology, but rarely from the social sciences. I was a bit surprised, therefore, to be invited to address the Thomas A. Pitts Memorial Lectureship on “Defining the Beginning and the End of Human Life.”


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