scholarly journals Are There Any Differences in Clinicopathological Features of Thyroid Cancer Between Diabetic and Non-Diabetic Patients?

2019 ◽  
Author(s):  
Fatma Dilek Dellal ◽  
Şefika Burçak Polat ◽  
Mustafa Ömer Yazıcıoğlu ◽  
Hayriye Tatlı Doğan ◽  
Reyhan Ersoy ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Clinicopathological Features ◽  
Diabetic Patients

scholarly journals Low urinary iodine is a protective factor of central lymph node metastasis in papillary thyroid cancer: a cross-sectional study

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Ziyang Zeng ◽  
Kang Li ◽  
Xianze Wang ◽  
Siwen Ouyang ◽  
Zimu Zhang ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Protective Factor ◽  
Urinary Iodine ◽  
Iodine Intake ◽  
Clinicopathological Features ◽  
Papillary Thyroid ◽  
Central Lymph Node ◽  
High Iodine ◽  
Central Lymph

Abstract Background An abrupt increase of thyroid cancer has been witnessed paralleling the supplemented iodine intake in formerly iodine-deficient countries. And increased iodine intake has been linked to the rising incidence rate of papillary thyroid cancer (PTC). However, the correlation between iodine and clinicopathological features of PTC has not been well-characterized. This study aimed to investigate the associations between iodine intake and the clinicopathological features of PTC patients. Methods Three hundred and fifty-nine PTC patients who received surgical treatment in Peking Union Medical College Hospital from May 2015 to November 2020 were retrospectively reviewed. The associations between urinary iodine (UI), urinary iodine/creatinine ratio (UI/U-Cr), and the clinicopathological features of PTC were analyzed. Univariate and multivariate analysis were performed to investigate the relationship between UI level and central lymph node metastasis (CLNM). Results There were no significant differences in UI in different groups according to the variables studied, except that patients with CLNM had higher UI level than CLNM(−) patients. No associations were found between UI/U-Cr and clinicopathological features except variant subtypes (classic/follicular). After dividing patients into high-iodine group and low-iodine group, more patients were found to have CLNM in the high-iodine group (p = 0.02). In addition, younger age, larger tumor size, and classic variant were positively correlated with CLNM (p < 0.05). Univariate analysis showed that insufficient iodine intake (≤ 99 μg/L) was associated with decreased CLNM risk in PTC. And after defining insufficient iodine intake as ≤ 109 μg/L and above requirements as ≥ 190 μg/L, multivariate analysis showed that lower iodine was associated with CLNM in total population of PTC (OR 0.53, 95% CI 0.31–0.91) and in PTC < 1 cm (papillary thyroid microcarcinoma, PTMC) (OR 0.43, 95% CI 0.21–0.87). Conclusions Low iodine was a protective factor for CLNM in papillary thyroid cancer, particularly in those < 1 cm. These results indicated that iodine may not only be an initiator of tumorigenesis, but also a promoter of the development of PTC.

Clinicopathological features of pancreatic cancer-related diabetes.

2020 ◽  
Vol 38 (4_suppl) ◽  
pp. 675-675
Author(s):  
Michael Lee ◽  
Hui-Li Wong ◽  
Erica S. Tsang ◽  
Sean McKay Fenlon Addison ◽  
James T. Topham ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Locally Advanced ◽  
Retrospective Chart Review ◽  
Clinicopathological Features ◽  
Initial Diagnosis ◽  
Ductal Adenocarcinoma ◽  
Diabetic Patients ◽  
Diabetes Diagnosis ◽  
Pancreatic Cancer Screening ◽  
Diabetes Status

675 Background: Epidemiological studies suggest pancreatic ductal adenocarcinoma (PDAC) may be strongly interrelated with diabetes. However, little is known about the clinicopathological features of pancreatic cancer related diabetes. Methods: A retrospective chart review was undertaken of all patients with advanced PDAC treated with at least one cycle of palliative chemotherapy at BC Cancer, Vancouver between Jan 2012- Dec 2015. Diagnosis of diabetes was determined by consultation documentation and/or fasting glucose > 7mmol/L or HbA1c > 48mmol/L. Peripancreatic diabetes is defined as diabetes diagnosis < 3 years prior to PDAC diagnosis. Results: 578 patients were identified with median age 66 (49-81), 54.6% male, 39.5% non-smoker and 63.5% ECOG 0/1. 27.3% confirmed diabetics, of which 75.8% (119/157) have peripancreatic diabetes. At initial diagnosis, 11.2% were deemed upfront resectable, 44.0% borderline/locally advanced, and 55.1% metastatic. Median overall survival (OS) for the cohort based on stage of disease at initial diagnosis for borderline, locally advanced and metastatic was 22 months (16.1-27.9), 12 months (10.1-13.9) and 6 months (5.0-7.0) respectively. There was no association with diabetes status and OS noted (p = 0.58). Statistical differences were noted in BMI (24.1 v 26.1, p = 0.003), and proportion of Charlson comorbidity index (CCI) of 2 (2.2 v 88.3%, p < 0.01) between non-diabetic and diabetic patients respectively. Statistical difference between peripancreatic diabetes compared to long-term diabetes were noted in resectable status (18.6 v 7.6%, p = 0.048), weight loss > 2kg (78.6 v 60.5%, p = 0.035), hypertension (25.9 v 59.8%, p = 0.002) and dyslipidemia (18.5 v 42.7%, p = 0.024). Conclusions: The majority of patients diagnosed with advanced PDAC with diabetes appeared to develop diabetes within 3 years prior to diagnosis. Further studies to assess the potential role of pancreatic cancer screening investigations in newly diagnosed diabetics are warranted.

scholarly journals Diabetes and Thyroid Cancer Risk: Literature Review

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Shyang-Rong Shih ◽  
Wei-Yih Chiu ◽  
Tien-Chun Chang ◽  
Chin-Hsiao Tseng
Keyword(s):  
Diabetes Mellitus ◽  
Thyroid Cancer ◽  
Cancer Risk ◽  
Pooled Analysis ◽  
Epidemiologic Studies ◽  
Thyroid Stimulating Hormone ◽  
Diabetic Patients ◽  
The Usa ◽  
Thyroid Cancer Risk ◽  
The Relationship

Diabetic patients have a higher risk of various types of cancer. However, whether diabetes may increase the risk of thyroid cancer has not been extensively studied. This paper reviews and summarizes the current literature studying the relationship between diabetes mellitus and thyroid cancer, and the possible mechanisms linking such an association. Epidemiologic studies showed significant or nonsignificant increases in thyroid cancer risk in diabetic women and nonsignificant increase or no change in thyroid cancer risk in diabetic men. A recent pooled analysis, including 5 prospective studies from the USA, showed that the summary hazard ratio (95% confidence interval) for women was 1.19 (0.84–1.69) and was 0.96 (0.65–1.42) for men. Therefore, the results are controversial and the association between diabetes and thyroid cancer is probably weak. Further studies are necessary to confirm their relationship. Proposed mechanisms for such a possible link between diabetes and thyroid cancer include elevated levels of thyroid-stimulating hormone, insulin, glucose and triglycerides, insulin resistance, obesity, vitamin D deficiency, and antidiabetic medications such as insulin or sulfonylureas.

scholarly journals PD-1 Ligand Expression in Epithelial Thyroid Cancers: Potential Clinical Implications

2019 ◽  
Vol 20 (6) ◽  
pp. 1405 ◽  
Author(s):  
Salvatore Ulisse ◽  
Chiara Tuccilli ◽  
Salvatore Sorrenti ◽  
Alessandro Antonelli ◽  
Poupak Fallahi ◽  
...  
Keyword(s):  
Cell Death ◽  
Thyroid Cancer ◽  
Prognostic Value ◽  
Clinicopathological Features ◽  
Clinical Implications ◽  
Thyroid Cancers ◽  
Promising Target ◽  
Programmed Cell Death 1 ◽  
Ligand Expression ◽  
Poorly Differentiated

The new immunotherapy targeting the programmed cell death 1 (PD-1) receptor and its cognate ligand PD-L1 has renewed hopes of eradicating the most difficult human cancers to treat. Among these, there are the poorly differentiated and anaplastic thyroid cancers, unresponsive to all the therapies currently in use. In the present review we will summarize information regarding the expression of PD-L1 in the different thyroid cancer histotypes, its correlation with clinicopathological features, and its potential prognostic value. Then, we will evaluate the available data indicating the PD-1/PD-L1 axis as a promising target for thyroid cancer therapy.

scholarly journals Association of obesity with the clinicopathological features of thyroid cancer in a large, operative population

Medicine ◽  
2019 ◽  
Vol 98 (50) ◽  
pp. e18213 ◽  
Author(s):  
Sitong Zhao ◽  
Xiaomeng Jia ◽  
Xiaojing Fan ◽  
Ling Zhao ◽  
Ping Pang ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Clinicopathological Features
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