scholarly journals Diabetes and Thyroid Cancer Risk: Literature Review

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Shyang-Rong Shih ◽  
Wei-Yih Chiu ◽  
Tien-Chun Chang ◽  
Chin-Hsiao Tseng
Keyword(s):  
Diabetes Mellitus ◽  
Thyroid Cancer ◽  
Cancer Risk ◽  
Pooled Analysis ◽  
Epidemiologic Studies ◽  
Thyroid Stimulating Hormone ◽  
Diabetic Patients ◽  
The Usa ◽  
Thyroid Cancer Risk ◽  
The Relationship

Diabetic patients have a higher risk of various types of cancer. However, whether diabetes may increase the risk of thyroid cancer has not been extensively studied. This paper reviews and summarizes the current literature studying the relationship between diabetes mellitus and thyroid cancer, and the possible mechanisms linking such an association. Epidemiologic studies showed significant or nonsignificant increases in thyroid cancer risk in diabetic women and nonsignificant increase or no change in thyroid cancer risk in diabetic men. A recent pooled analysis, including 5 prospective studies from the USA, showed that the summary hazard ratio (95% confidence interval) for women was 1.19 (0.84–1.69) and was 0.96 (0.65–1.42) for men. Therefore, the results are controversial and the association between diabetes and thyroid cancer is probably weak. Further studies are necessary to confirm their relationship. Proposed mechanisms for such a possible link between diabetes and thyroid cancer include elevated levels of thyroid-stimulating hormone, insulin, glucose and triglycerides, insulin resistance, obesity, vitamin D deficiency, and antidiabetic medications such as insulin or sulfonylureas.

scholarly journals Anthropometric Factors and Thyroid Cancer Risk by Histological Subtype: Pooled Analysis of 22 Prospective Studies

Thyroid ◽  
2016 ◽  
Vol 26 (2) ◽  
pp. 306-318 ◽  
Author(s):  
Cari M. Kitahara ◽  
Marjorie L. McCullough ◽  
Silvia Franceschi ◽  
Sabina Rinaldi ◽  
Alicja Wolk ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Risk ◽  
Prospective Studies ◽  
Pooled Analysis ◽  
Histological Subtype ◽  
Thyroid Cancer Risk

Diabetes and risk of tumors: oncologic considerations

2011 ◽  
Vol 152 (29) ◽  
pp. 1144-1155 ◽  
Author(s):  
András Rosta
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cancer Risk ◽  
Malignant Tumors ◽  
Epidemiologic Studies ◽  
Treatment Modalities ◽  
Diabetic Patients ◽  
Antidiabetic Treatment

Type 2 diabetes mellitus and malignant tumors are frequent diseases worldwide. The incidence of these two diseases is growing continuously and causes serious health care problem. Population based epidemiologic studies show that the coexistence of type 2 diabetes and malignant tumors is more frequent than expected by the age-corrected incidence and prevalence of each disease. Epidemiologic studies and meta-analyses show that type 2 diabetes increases the risk and tumor specific mortality of certain cancers. The overlapping risk factors of the diseases suggest a relationship between type 2 diabetes and malignant tumors, with a significant role of obesity as a major risk factor. In the pathophysiology of type 2 diabetes there are several biological processes, which may explain the higher cancer risk in type 2 diabetes. In vitro experiments, and in vivo animal studies show that the mitotic effect of hyperinsulinemia plays an important role in the relationship of cancer and type 2 diabetes mellitus. Recent studies show that the different treatment modalities, antidiabetic drugs and their combinations used for the treatment of type 2 diabetes can modify cancer risk. The majority of the data show that metformin therapy decreases, while insulin secretagog drugs slightly increase the risk of certain types of cancers in type 2 diabetes. Metformin can decrease cell proliferation and induce apoptosis in certain cancer cell lines. Endogenous and exogenous (therapy induced) hyperinsulinemia may be mitogenic and may increase the risk of cancer in type 2 diabetes. Human studies showed that the analogue insulin glargin increases the risk of certain cancers. As a result of conceptual weaknesses in study design, data collection, and statistical methods the results of these studies are questionable. According to present knowledge, obtaining and maintaining optimal metabolic target values with the appropriate choice of treatment modality is the aim of treatment in type 2 diabetes. Presently, study results showing elevated mitogenic potential with some antidiabetic treatment modalities are not taken into account, when considering the choice of antidiabetic treatment in type 2 diabetic patients. In the care of patients with increased cancer risk, oncologic considerations should be taken into account. Well designed, prospective, clinical studies would be necessary to demonstrate the possible correlation between treatment modalities of type 2 diabetes and change of cancer risk in type 2 diabetes mellitus. Orv. Hetil., 2011, 152, 1144–1155.

scholarly journals Association of diabetes mellitus with thyroid cancer risk

Medicine ◽  
2017 ◽  
Vol 96 (47) ◽  
pp. e8230 ◽  
Author(s):  
Hongtao Li ◽  
Jun Qian
Keyword(s):  
Diabetes Mellitus ◽  
Thyroid Cancer ◽  
Cancer Risk ◽  
Thyroid Cancer Risk

scholarly journals Physical activity, diabetes, and thyroid cancer risk: a pooled analysis of five prospective studies

2012 ◽  
Vol 23 (3) ◽  
pp. 463-471 ◽  
Author(s):  
Cari M. Kitahara ◽  
Elizabeth A. Platz ◽  
Laura E. Beane Freeman ◽  
Amanda Black ◽  
Ann W. Hsing ◽  
...  
Keyword(s):  
Physical Activity ◽  
Thyroid Cancer ◽  
Cancer Risk ◽  
Prospective Studies ◽  
Pooled Analysis ◽  
Thyroid Cancer Risk

scholarly journals Obesity and Thyroid Cancer Risk among U.S. Men and Women: A Pooled Analysis of Five Prospective Studies

2011 ◽  
Vol 20 (3) ◽  
pp. 464-472 ◽  
Author(s):  
Cari M. Kitahara ◽  
Elizabeth A. Platz ◽  
Laura E. Beane Freeman ◽  
Ann W. Hsing ◽  
Martha S. Linet ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Risk ◽  
Prospective Studies ◽  
Pooled Analysis ◽  
Men And Women ◽  
Thyroid Cancer Risk

scholarly journals Body mass index and thyroid cancer risk – A pooled analysis of half a million men and women in the Asia Cohort Consortium

Thyroid ◽  
2021 ◽  
Author(s):  
Aesun Shin ◽  
Sooyoung Cho ◽  
Doeun Jang ◽  
Sarah Krull Abe ◽  
Eiko Saito ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Thyroid Cancer ◽  
Cancer Risk ◽  
Body Mass ◽  
Pooled Analysis ◽  
Men And Women ◽  
Thyroid Cancer Risk
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