scholarly journals Clinicopathologic features and KRAS mutation incidence of gastric carcinomas

2022 ◽  
Vol 12 (1) ◽  
pp. 1-5
Author(s):  
Didar GÜRSOY ◽  
İlke Evrim SEÇİNTİ ◽  
Esin DOĞAN ◽  
Muhyittin TEMİZ
Keyword(s):  
Kras Mutation ◽  
Clinicopathologic Features ◽  
Gastric Carcinomas

Clinicopathologic Features and Prognosis of Synchronous Multiple Gastric Carcinomas

2012 ◽  
Vol 112 (2) ◽  
pp. 148-153 ◽  
Author(s):  
H.G. Kim ◽  
S.Y. Ryu ◽  
J.H. Lee ◽  
D.Y. Kim
Keyword(s):  
Clinicopathologic Features ◽  
Gastric Carcinomas

scholarly journals P010 Relationship Between EGFR and KRAS Mutation and the Clinicopathologic Features of Early Lung Adenocarcinoma

2018 ◽  
Vol 13 (12) ◽  
pp. S1053-S1054
Author(s):  
D. Jiang ◽  
S. Wang ◽  
F. Huang ◽  
X. Zhang ◽  
H. Jin ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Kras Mutation ◽  
Clinicopathologic Features

EBV-Positive Gastric Adenocarcinomas: A Distinct Clinicopathologic Entity With a Low Frequency of Lymph Node Involvement

2004 ◽  
Vol 22 (4) ◽  
pp. 664-670 ◽  
Author(s):  
Josine van Beek ◽  
Axel zur Hausen ◽  
Elma Klein Kranenbarg ◽  
Cornelis J.H. van de Velde ◽  
Jaap M. Middeldorp ◽  
...  
Keyword(s):  
Lymph Node ◽  
Residual Disease ◽  
Low Frequency ◽  
Proximal Part ◽  
Lymph Node Involvement ◽  
Clinicopathologic Features ◽  
Gastric Carcinomas ◽  
Barr Virus ◽  
Gastric Adenocarcinomas ◽  
Genomic Aberrations

Purpose Epstein-Barr virus (EBV) is detected in a substantial subgroup of gastric adenocarcinomas worldwide. We have previously reported that these EBV-positive gastric carcinomas carry distinct genomic aberrations. In the present study, we analyzed a large cohort of EBV-positive and EBV-negative gastric adenocarcinomas for their clinicopathologic features to determine whether they constitute a different clinical entity. Patients and Methods Using a validated polymerase chain reaction/enzyme immunoassay–based prescreening method in combination with EBER1/2-RNA in situ hybridization, EBV was detected in the tumor cells of 7.2% (n = 41) of the gastric carcinomas from the Dutch D1D2 trial (N = 566; mean follow-up, 9 years). EBV status was correlated with clinicopathologic features collected for the Dutch D1D2 trial. Results EBV-positive gastric carcinomas occurred significantly more frequently in males (P < .0001) and in younger patients (P = .012). Most were of the intestinal type according to the Laurén classification (P = .047) or tubular according to the WHO classification (P = .006) and located in the proximal part of the stomach (P < .0001). A significantly lower tumor-node-metastasis system-stage (P = .026) was observed in the patients with EBV-carrying carcinomas, which was solely explained by less lymph node (LN) involvement (P = .034) in these cases. In addition, a better prognosis, as reflected by a longer disease-free period (P = .04) and a significant better cancer-related survival (P = .02), was observed for these patients, which could be explained by less LN involvement, less residual disease, and younger patient age. Conclusion EBV-carrying gastric adenocarcinomas are a distinct entity of carcinomas, characterized not only by unique genomic aberrations, but also by distinct clinicopathologic features associated with significantly better prognosis.

Multiple early gastric carcinomas: Clinicopathologic features and histogenesis

Cancer ◽  
1996 ◽  
Vol 78 (10) ◽  
pp. 2078-2086 ◽  
Author(s):  
Hiroshi Isozaki ◽  
Kunio Okajima ◽  
Xiang Hu ◽  
Keizo Fujii ◽  
Shozo Sako
Keyword(s):  
Clinicopathologic Features ◽  
Gastric Carcinomas
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