Genetic, epigenetic, and clinicopathologic features of gastric carcinomas with the CpG island methylator phenotype and an association with Epstein–Barr virus

Cancer ◽  
2006 ◽  
Vol 106 (7) ◽  
pp. 1467-1479 ◽  
Author(s):  
Masanobu Kusano ◽  
Minoru Toyota ◽  
Hiromu Suzuki ◽  
Kimishige Akino ◽  
Fumio Aoki ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Cpg Island ◽  
Clinicopathologic Features ◽  
Cpg Island Methylator Phenotype ◽  
Gastric Carcinomas ◽  
Barr Virus ◽  
Epstein Barr ◽  
Methylator Phenotype

Epstein-Barr Virus in Gastric Carcinomas from Singapore

1996 ◽  
Vol 4 (3) ◽  
pp. 149-158
Author(s):  
Gary D. Clark ◽  
Yoke Sun Lee ◽  
Kyung-Whan Min ◽  
S. Terence Dunn
Keyword(s):  
Epstein Barr Virus ◽  
Gastric Carcinomas ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Epstein-Barr Virus, Beta-Catenin, and E-cadherin in Gastric Carcinomas

2007 ◽  
Vol 22 (5) ◽  
pp. 855 ◽  
Author(s):  
In Mok Jung ◽  
Jung Kee Chung ◽  
Young A Kim ◽  
Je Eun Kim ◽  
Seung Chul Heo ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Beta Catenin ◽  
Gastric Carcinomas ◽  
Barr Virus ◽  
Epstein Barr ◽  
E Cadherin

scholarly journals Detection of Epstein-Barr Virus in 130 Cases of Eyelid Sebaceous Gland Carcinoma Using In Situ Hybridization

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Huanhuan Gao ◽  
Lijuan Tang ◽  
Jianxian Lin ◽  
Wenxin Zhang ◽  
Yongping Li ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Sebaceous Gland ◽  
Epstein Barr Virus ◽  
Clinicopathologic Features ◽  
Tumor Differentiation ◽  
Sebaceous Gland Carcinoma ◽  
Barr Virus ◽  
Gland Carcinoma ◽  
Epstein Barr

Purpose. In this study, we aimed to investigate the presence of Epstein–Barr virus (EBV) in the eyelid sebaceous gland carcinoma (SGC) and its association with the clinicopathologic features. Methods. One hundred and thirty paraffin-embedded SGC specimens were retrieved from the Clinical Pathology Department of Zhongshan Ophthalmic Center. Epstein–Barr virus-encoded RNA (EBER) was detected with in situ hybridization (ISH) using the Leica BOND system autostainer. The age and gender distributions of all patients were analyzed and compared with earlier reports. Pearson’s χ2 and Fisher’s exact tests were used to determine the association between clinicopathological features such as age, gender, laterality eye, tumor basal dimension, degree of tumor differentiation, and EBER positivity. Likewise, the relationship between the grade and tumor basal dimension in EBER-positive SGC of the eyelid was analyzed. Results. Thirty-four out of one hundred and thirty (26.2%) eyelid SGC specimens were positively stained for EBER. The age range of highest incidence was 46–75 years, and the female to male ratio was 1 : 0.9. No significant correlation was found between EBER-positivity and age (p=0.5370), gender (p=0.4758), and degree of tumor differentiation (p=0.7787). However, EBV positivity was strongly correlated with the right eye (p=0.0287), the tumor basal dimension (p=0.0001). EBV positivity grade presented statistically associated with tumor size (p=0.0329). Conclusion. We conclude that ISH is a sensitive method to identify EBV in SGC of the eyelid. A possible causal association of EBV in SGC patients is suggested by high frequency of EBER-ISH positivity and its association with the clinicopathologic features.

Epstein–Barr virus-encoded miR-BART5-5p upregulates PD-L1 through PIAS3/pSTAT3 modulation, worsening clinical outcomes of PD-L1-positive gastric carcinomas

2020 ◽  
Vol 23 (5) ◽  
pp. 780-795 ◽  
Author(s):  
Chan Jin Yoon ◽  
Mee Soo Chang ◽  
Dong Ha Kim ◽  
Won Kim ◽  
Bo Kyung Koo ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Epstein Barr Virus ◽  
Gastric Carcinomas ◽  
Barr Virus ◽  
Epstein Barr
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