Small increases in dietary calcium above normal requirements exacerbate magnesium deficiency in rats fed a low magnesium diet

2014 ◽  
Vol 27 (1) ◽  
pp. 35-47 ◽  
Author(s):  
Jesse Bertinato ◽  
Christopher Lavergne ◽  
Louise J. Plouffe ◽  
Hiba Abou El Niaj
Keyword(s):  
Magnesium Deficiency ◽  
Dietary Calcium ◽  
Low Magnesium

scholarly journals Magnesium Deficiency Induces Lipid Accumulation in Vascular Endothelial Cells via Oxidative Stress—The Potential Contribution of EDF-1 and PPARγ

2021 ◽  
Vol 22 (3) ◽  
pp. 1050
Author(s):  
Laura Locatelli ◽  
Giorgia Fedele ◽  
Sara Castiglioni ◽  
Jeanette A. Maier
Keyword(s):  
Endothelial Cells ◽  
Vascular Endothelial Cells ◽  
Magnesium Deficiency ◽  
Umbilical Vein ◽  
Potential Contribution ◽  
Vascular Endothelial ◽  
Oxygen Species ◽  
Human Endothelial Cells ◽  
Intracellular Lipids ◽  
Low Magnesium

Background: Magnesium deficiency contributes to atherogenesis partly by promoting the dysfunction of endothelial cells, which are critical in vascular homeostasis and diseases. Since EDF-1 and PPARγ regulate crucial endothelial activities, we investigated the modulation of these proteins involved in lipogenesis as well the deposition of lipids in human endothelial cells cultured in different concentrations of magnesium. Methods: Human endothelial cells from the umbilical vein were cultured in medium containing from 0.1 to 5 mM magnesium for 24 h. The levels of EDF-1 and PPARγ were visualized by Western blot. Reactive oxygen species (ROS) were measured by DCFDA. Lipids were detected after O Red Oil staining. Results: Magnesium deficiency leads to the accumulation of ROS which upregulate EDF-1. Further, PPARγ is increased after culture in low magnesium, but independently from ROS. Moreover, lipids accumulate in magnesium-deficient cells. Conclusions: Our results suggest that magnesium deficiency leads to the deposition of lipids by inducing EDF-1 and PPARγ. The increase in intracellular lipids might be interpreted as an adaptive response of endothelial cells to magnesium deficiency.

Functional characterization of human SLC41A1, a Mg2+transporter with similarity to prokaryotic MgtE Mg2+transporters

2005 ◽  
Vol 21 (3) ◽  
pp. 337-342 ◽  
Author(s):  
Angela Goytain ◽  
Gary A. Quamme
Keyword(s):  
Epithelial Cells ◽  
Magnesium Deficiency ◽  
Divalent Cations ◽  
Functional Characterization ◽  
Distal Tubule ◽  
Kidney Cortex ◽  
Xenopus Laevis Oocytes ◽  
Magnesium Homeostasis ◽  
Low Magnesium ◽  
Voltage Dependent

We have begun to identify and characterize genes that are differentially expressed with low magnesium. One of these sequences conformed to the solute carrier SLC41A1. Real-time RT-PCR of RNA isolated from renal distal tubule epithelial [mouse distal convoluted tubule (MDCT)] cells cultured in low-magnesium media relative to normal media and in the kidney cortex of mice maintained on low-magnesium diets compared with those animals consuming normal diets confirmed that the SLC41A1 transcript is responsive to magnesium. Mouse SLC41A1 was cloned from MDCT cells, expressed in Xenopus laevis oocytes, and studied with two-electrode voltage-clamp studies. When expressed in oocytes, SLC41A1 mediates saturable Mg2+uptake with a Michaelis constant of 0.67 mM. Transport of Mg2+by SLC41A1 is rheogenic, voltage dependent, and not coupled to Na+or Cl−. Expressed SLC41A1 transports a range of other divalent cations: Mg2+, Sr2+, Zn2+, Cu2+, Fe2+, Co2+, Ba2+, and Cd2+. The divalent cations Ca2+, Mn2+, and Ni2+and the trivalent ion Gd3+did not induce currents nor did they inhibit Mg2+transport. The nonselective cation La3+abolished Mg2+uptake. The SLC41A1 transcript is present in many tissues, notably renal epithelial cells, and is upregulated in some tissues with magnesium deficiency. These studies suggest that SLC41A1 is a regulated Mg2+transporter that might be involved in magnesium homeostasis in epithelial cells.

scholarly journals Frequency of Hypomagnesaemia in Children with Hypocalcemic Seizures

2021 ◽  
pp. 514-518
Author(s):  
Muhammad Iqbal ◽  
Farzana Shaikh ◽  
Abdul Hameed Radhan ◽  
Muhammad Nadeem Chohan ◽  
Khuda Bux Khoso ◽  
...  
Keyword(s):  
Magnesium Deficiency ◽  
Serum Magnesium ◽  
Magnesium Level ◽  
Common Type ◽  
University Hospital ◽  
Positive Relation ◽  
Cross Sectional ◽  
Low Magnesium ◽  
The Common ◽  
Low Levels

Aim: To determine the frequency of hypomagnesaemia in children with hypocalcemic seizures. Study Design:  Cross sectional descriptive study. Place and Duration: Department of Pediatrics, Liaquat University Hospital, Jamshoro / Hyderabad. From November 2017 to April 2018. Methodology: Children (06 months to 06 years age and of either gender) having Two or more than two hypocalcemic seizures within 12 hours duration were included in the study . The children with hypocalcemic seizure were assessed for magnesium deficiency (hypomagnesaemia). The evaluation of hypomagnesaemia was done according to the cut off / reference values for hypomagnesaemia (<1.8 mg/dl). The data was collected on pre-structured proforma (attached). Results: Total 147 children with hypocalcemic seizures were taken in this study, among them 49 (33.3%) patients had found low magnesium level and 98 (54.4%) patients had normal magnesium level. Conclusion: Seizures associated with hypocalcaemia is one of the common type of convulsion in children. In our study, a positive relation was found between low levels of serum magnesium and hypocalcemic seizures.

The maize CorA/MRS2/MGT-type Mg transporter, ZmMGT10, responses to magnesium deficiency and confers low magnesium tolerance in transgenic Arabidopsis

2017 ◽  
Vol 95 (3) ◽  
pp. 269-278 ◽  
Author(s):  
Hongyou Li ◽  
Ning Wang ◽  
Jianzhou Ding ◽  
Chan Liu ◽  
Hanmei Du ◽  
...  
Keyword(s):  
Transgenic Arabidopsis ◽  
Magnesium Deficiency ◽  
Low Magnesium

Magnesium in pregnancy and breastfeeding

2015 ◽  
Author(s):  
Sir Peter Gluckman ◽  
Mark Hanson ◽  
Chong Yap Seng ◽  
Anne Bardsley
Keyword(s):  
Metabolic Disorders ◽  
Preterm Labour ◽  
Magnesium Deficiency ◽  
Current Evidence ◽  
Uterine Contractility ◽  
Magnesium Supplementation ◽  
Low Magnesium ◽  
Physiological Processes ◽  
Malabsorption Syndromes ◽  
In Pregnancy

Magnesium in important for a wide variety of physiological processes; prominent among them is the control of muscle contractions, cardiac function, and carbohydrate metabolism. In pregnancy, low magnesium status is associated with hypertension, pre-eclampsia, gestational diabetes, leg cramping, and preterm labour. Magnesium has been used extensively in obstetrics to reduce uterine contractility in threatened preterm labour. Although current evidence does not support a requirement for magnesium supplementation for most pregnant women, those who are overweight, have risk factors for hypertensive or metabolic disorders or malabsorption syndromes, or who are carrying multiple fetuses, should pay particular attention to their diets and should be monitored for signs of magnesium deficiency. Consuming a magnesium-rich diet throughout pregnancy is recommended.

scholarly journals Magnesium Status and Stress: The Vicious Circle Concept Revisited

Nutrients ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3672
Author(s):  
Gisèle Pickering ◽  
André Mazur ◽  
Marion Trousselard ◽  
Przemyslaw Bienkowski ◽  
Natalia Yaltsewa ◽  
...  
Keyword(s):  
Stress Response ◽  
Physiological Stress ◽  
Magnesium Deficiency ◽  
Vicious Circle ◽  
Clinical Settings ◽  
Low Magnesium ◽  
Physiological Stress Response ◽  
Associated Symptoms ◽  
Magnesium Status ◽  
Magnesium Loss

Magnesium deficiency and stress are both common conditions among the general population, which, over time, can increase the risk of health consequences. Numerous studies, both in pre-clinical and clinical settings, have investigated the interaction of magnesium with key mediators of the physiological stress response, and demonstrated that magnesium plays an inhibitory key role in the regulation and neurotransmission of the normal stress response. Furthermore, low magnesium status has been reported in several studies assessing nutritional aspects in subjects suffering from psychological stress or associated symptoms. This overlap in the results suggests that stress could increase magnesium loss, causing a deficiency; and in turn, magnesium deficiency could enhance the body’s susceptibility to stress, resulting in a magnesium and stress vicious circle. This review revisits the magnesium and stress vicious circle concept, first introduced in the early 1990s, in light of recent available data.

scholarly journals Physiological characterisation of magnesium deficiency in sugar beet: acclimation to low magnesium differentially affects photosystems�I and II

Planta ◽  
2004 ◽  
Vol 220 (2) ◽  
pp. 344-355 ◽  
Author(s):  
Christian Hermans ◽  
Giles N. Johnson ◽  
Reto J. Strasser ◽  
Nathalie Verbruggen
Keyword(s):  
Sugar Beet ◽  
Magnesium Deficiency ◽  
Low Magnesium ◽  
Photosystems I And Ii

scholarly journals Dietary Intake of Calcium and Magnesium in Relation to Severe Headache or Migraine

2021 ◽  
Vol 8 ◽  
Author(s):  
Shu-Han Meng ◽  
Ming-Xue Wang ◽  
Li-Xin Kang ◽  
Jin-Ming Fu ◽  
Hai-Bo Zhou ◽  
...  
Keyword(s):  
Dietary Intake ◽  
Dietary Calcium ◽  
Severe Headache ◽  
Spline Regression ◽  
Low Magnesium ◽  
Health And Nutrition ◽  
High Calcium ◽  
Dietary Magnesium ◽  
High Dietary Intake ◽  
Calcium And Magnesium

Background: Migraine is a common neurological disorder and is affected by nutrients. Calcium and magnesium are essential minerals that play an important role in nerve function. So we investigated the association between dietary calcium and magnesium and migraine.Methods: We extracted 10,798 adults from the National Health and Nutrition Examination Surveys (NHANES) of America in 1999 to 2004. We classified patients who reported having severe headache or migraine as having possible migraine. Multivariable logistic regression and restricted cubic spline regression were conducted to determine the association between dietary calcium and magnesium and migraine.Results: We found that the adjusted ORs of the association between dietary calcium and magnesium and migraine for comparing the highest quintile intake with the lowest quintile intake were 0.77 (95% CI: 0.63–0.93, P = 0.008) and 0.69 (95% CI: 0.55–0.86, P = 0.001), respectively. For women, the adjusted ORs of dietary calcium and magnesium were 0.72 (95% CI: 0.56–0.93, P = 0.009) and 0.62 (95% CI: 0.47–0.83, P = 0.001), respectively. For men, the adjusted OR was 0.71 (95% CI: 0.52–0.97, P = 0.028) comparing the highest and the lowest quintile of calcium intake, but there was no statistically significant association between dietary magnesium intake and migraine. Joint analyses showed that the OR in the high-calcium and high-magnesium group was 0.74 (95% CI: 0.60–0.92, P = 0.006) compared with the low-calcium and low-magnesium group in women.Conclusions: High dietary intake of calcium and magnesium, independently or in combination, were inversely associated with migraine in women. For men, high dietary calcium was negatively related to migraine, but magnesium was not associated with migraine.

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