scholarly journals Magnesium Status and Stress: The Vicious Circle Concept Revisited

Nutrients ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3672
Author(s):  
Gisèle Pickering ◽  
André Mazur ◽  
Marion Trousselard ◽  
Przemyslaw Bienkowski ◽  
Natalia Yaltsewa ◽  
...  

Magnesium deficiency and stress are both common conditions among the general population, which, over time, can increase the risk of health consequences. Numerous studies, both in pre-clinical and clinical settings, have investigated the interaction of magnesium with key mediators of the physiological stress response, and demonstrated that magnesium plays an inhibitory key role in the regulation and neurotransmission of the normal stress response. Furthermore, low magnesium status has been reported in several studies assessing nutritional aspects in subjects suffering from psychological stress or associated symptoms. This overlap in the results suggests that stress could increase magnesium loss, causing a deficiency; and in turn, magnesium deficiency could enhance the body’s susceptibility to stress, resulting in a magnesium and stress vicious circle. This review revisits the magnesium and stress vicious circle concept, first introduced in the early 1990s, in light of recent available data.

2021 ◽  
Vol 239 ◽  
pp. 105940
Author(s):  
Laura Simões Andrade ◽  
Domingos Garrone-Neto ◽  
Manuela Alves Nobre Sales ◽  
Luciana Rodrigues de Souza-Bastos ◽  
Ursulla Pereira Souza ◽  
...  

2009 ◽  
Vol 73 (4) ◽  
pp. 609-614 ◽  
Author(s):  
Remington J. Moll ◽  
Joshua J. Millspaugh ◽  
Jeff Beringer ◽  
Joel Sartwell ◽  
Rami J. Woods ◽  
...  

2011 ◽  
Vol 43 (Suppl 1) ◽  
pp. 905-906
Author(s):  
Michael J. Ormsbee ◽  
Amber W. Kinsey ◽  
Minwook Chong ◽  
Heather S. Friedman ◽  
Tonya Dodge ◽  
...  

2020 ◽  
pp. 101-118
Author(s):  
James M. Bjork ◽  
Nicholas D. Thomson

Stress is both a critical contributor and consequence of substance use disorder (SUD). First, exaggerated subjective stress responses are characteristic of affective symptomatology such as depression, bipolar disorder, generalized anxiety, and posttraumatic stress disorder (sometimes stemming from histories of abuse) that have been prognostic of development of addiction in longitudinal studies. Substance use is negatively reinforced in many at-risk and addicted individuals because it may acutely alleviate stress. Second, chronic administration of commonly abused substances alters physiological stress response systems, especially during acute withdrawal. Third, acute stress responses blunt the addicted individual’s frontocortically mediated behavioral repertoire (solution space) in favor of reflexive behavioral biases toward relief-based substance use. Therefore, acute stress responses are a strong trigger for relapse to substance use during extended recovery. These findings have collectively led to approaches to SUD relapse prevention that pharmacologically blunt components of the stress response, but these agents have not reliably shown success in human clinical trials. This chapter reviews these different relationships between stress and addiction and offers future avenues for additional research.


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