Incipiens linear IgA disease with IgA antibodies directed against 200-kDa epidermal antigens

2011 ◽  
Vol 21 (3) ◽  
pp. 411-412
Author(s):  
Karen TALOUR ◽  
Allan KARAM ◽  
Nadège DREUX ◽  
Gilles LEMASSON ◽  
Daniele GILBERT ◽  
...  
Keyword(s):  
Iga Antibodies ◽  
Linear Iga Disease ◽  
Epidermal Antigens

Linear IgA disease with IgA antibodies directed against 200- and 280-kDa epidermal antigens

2000 ◽  
Vol 142 (6) ◽  
pp. 1213-1218 ◽  
Author(s):  
W. Fujimoto ◽  
T. Ohtsu ◽  
Y. Toi ◽  
G. Nakanishi ◽  
J. Arata
Keyword(s):  
Iga Antibodies ◽  
Linear Iga Disease ◽  
Epidermal Antigens

Linear IgA disease with circulating IgA antibodies against the NC16A domain of BP180

1999 ◽  
Vol 140 (5) ◽  
pp. 964-966 ◽  
Author(s):  
E Schmidt ◽  
K Herzele ◽  
H Schumann ◽  
U Wesselmann ◽  
I Chimanovitch ◽  
...  
Keyword(s):  
Iga Antibodies ◽  
Linear Iga Disease

Linear IgA Disease Initially Presenting with Linear IgA and IgG Deposits.

1996 ◽  
Vol 58 (1) ◽  
pp. 26-28 ◽  
Author(s):  
Makoto INAOKI ◽  
Kiyohiro TSUTSUI ◽  
Kazuhiko TAKEHARA
Keyword(s):  
Linear Iga Disease

IgA Antibodies in the Vaginal Secretion after Vaccination with SolcoTrichovac

1983 ◽  
Vol 23 (2) ◽  
pp. 46-49 ◽  
Author(s):  
R. Milovanović ◽  
R. Grčić ◽  
L. Stojković
Keyword(s):  
Vaginal Secretion ◽  
Iga Antibodies

scholarly journals Antibody in Middle Ear Fluid of Children Originates Predominantly from Sera and Nasopharyngeal Secretions

2012 ◽  
Vol 19 (10) ◽  
pp. 1593-1596 ◽  
Author(s):  
Ravinder Kaur ◽  
Thomas Kim ◽  
Janet R. Casey ◽  
Michael E. Pichichero
Keyword(s):  
Middle Ear ◽  
Acute Otitis Media ◽  
Secretory Iga ◽  
Enzyme Linked Immunosorbent Assay ◽  
Serum Samples ◽  
Two Dimensional Gel Electrophoresis ◽  
Middle Ear Fluid ◽  
Iga Antibodies ◽  
Iga Antibody ◽  
Entire Array

ABSTRACTThe human middle ear is devoid of any immunocompetent cells in normal mucosa. We sought to determine the source of antibody present in the middle ear of children. Total IgG, IgA, and secretory IgA antibodies were determined by enzyme-linked immunosorbent assay from the nasopharyngeal, middle ear, and serum samples of children with acute otitis media. The two-dimensional gel electrophoresis pattern of the entire array of IgA antibodies in the nasal wash (NW) and middle ear fluid (MEF) was compared from the MEF and NW samples using isoelectric focusing and Western blotting. The total IgG and IgA antibodies in the MEF and NW samples of 137 children were compared. The ratio of IgG to IgA in the MEF was significantly different (P< 0.008) compared to NW because IgA levels were higher and IgG levels lower in NW. The IgG/IgA ratio of MEF resembled serum consistent with transudation to the MEF. Small amounts of secretory IgA were detected in MEF but the electrophoresis patterns of the entire array of IgA antibodies in the MEF and NW were virtually identical in each child evaluated; thus, IgA in MEF derived predominantly from serum and the nasopharynx by reflux via the Eustachian tube. The IgG/IgA antibody levels in the MEF and the same composition of IgA antibody in the MEF and NW identifies the predominant source of antibody in the MEF as a transudate of serum combined with nasal secretions refluxed from the nasopharynx in children.

scholarly journals Rapid seroconversion and persistent functional IgG antibodies in severe COVID-19 patients correlates with an IL-12p70 and IL-33 signature

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ariel Munitz ◽  
L. Edry-Botzer ◽  
M. Itan ◽  
R. Tur-Kaspa ◽  
D. Dicker ◽  
...  
Keyword(s):  
Nucleocapsid Protein ◽  
Neutralizing Antibodies ◽  
Host Response ◽  
Humoral Response ◽  
Rapid Onset ◽  
Response Analysis ◽  
Receptor Binding Domain ◽  
Igg Antibodies ◽  
Viral Receptor ◽  
Iga Antibodies

AbstractDespite ongoing efforts to characterize the host response toward SARS-CoV-2, a major gap in our knowledge still exists regarding the magnitude and duration of the humoral response. Analysis of the antibody response in mild versus moderate/severe patients, using our new developed quantitative electrochemiluminescent assay for detecting IgM/IgA/IgG antibodies toward SARS-CoV-2 antigens, revealed a rapid onset of IgG/IgA antibodies, specifically in moderate/severe patients. IgM antibodies against the viral receptor binding domain, but not against nucleocapsid protein, were detected at early stages of the disease. Furthermore, we observed a marked reduction in IgM/IgA antibodies over-time. Adapting our assay for ACE2 binding-competition, demonstrated that the presence of potentially neutralizing antibodies is corelated with IgG/IgA. Finally, analysis of the cytokine profile in COVID-19 patients revealed unique correlation of an IL-12p70/IL33 and IgG seroconversion, which correlated with disease severity. In summary, our comprehensive analysis has major implications on the understanding and monitoring of SARS-CoV-2 infections.

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