Interleukin-27 gene variant rs153109 is associated with enhanced cytokine serum levels and susceptibility to Behçet's disease in the Iranian population

2020 ◽  
Vol 31 (4) ◽  
pp. 140-146
Author(s):  
Nasser Gholijani ◽  
Gholamreza Daryabor ◽  
Kurosh Kalantar ◽  
Mohammad-Reza Yazdani ◽  
Saeedeh Shenavandeh ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Serum Levels ◽  
Iranian Population ◽  
Gene Variant ◽  
Behcet's Disease ◽  
Interleukin 27

scholarly journals Expression of TNF-α, April and BCMA in Behcet’s Disease

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Olfat G. Shaker ◽  
Shereen O. Tawfic ◽  
Amira M. El-Tawdy ◽  
Mohamed H. M. El-Komy ◽  
Manal El Menyawi ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
B Cell ◽  
Behçet’S Disease ◽  
Tumor Necrosis ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Serum Levels ◽  
Behcet's Disease ◽  
B Cell Activating Factor ◽  
Necrosis Factor

Background. Tumor necrosis factor-alpha (TNF-α) is an important proinflammatory cytokine which plays an important role in the immunopathogenesis of Behcet’s disease (BD). B cell activating factor (BAFF) and its homolog A proliferation inducing ligand (APRIL) are members of the tumor necrosis factor family. BAFF binds to 3 receptors, B cell activating factor receptor (BAFF-R), transmembrane activator and calcium modulator ligand interactor (TACI), and B cell maturation antigen (BCMA) that are expressed by B cells.Objective. Estimation of the serum levels of TNF-α, APRIL, BAFF, and BCMA in patients with BD in an effort to evaluate their degree of involvement in the pathogenesis and development of BD.Patients and Methods. This study included 30 male patients fulfilling the international study group criteria for the diagnosis of BD. Twenty age-matched healthy male volunteers served as control. Serum samples were used for quantification of TNF-α, APRIL, BCMA, BAFF, and hsCRP using ELISA techniques.Results. The mean serum levels of TNF-α, APRIL, BCMA, and BAFF were more elevated in cases than in controls in a statistically significant manner(P<0.001). Positive correlation was observed between hs-CRP and BDCAF (Behcet’s disease current activity forum) index (r0.68,P<0.001). None of the TNF family members tested was affected by a positive pathergy test.Conclusions. Patients have significantly higher levels of TNF family members’ (TNF-α, BAFF, APRIL, and BCMA) compared to controls which might contribute to the pathogenesis of BD.

Ubiquitin Associated and SH3 Domain Containing B (UBASH3B) Gene Association with Behcet’s Disease in Iranian Population

2018 ◽  
Vol 44 (2) ◽  
pp. 200-205 ◽  
Author(s):  
Elham Shahriyari ◽  
Mortaza Bonyadi ◽  
Mohammad Hossein Jabbarpoor Bonyadi ◽  
Masoud Soheilian ◽  
Mehdi Yaseri ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Sh3 Domain ◽  
Iranian Population ◽  
Behcet's Disease ◽  
Gene Association

Serum Levels of Interleukin-2 Receptor in Ocular Behçet's Disease

1993 ◽  
Vol 115 (1) ◽  
pp. 26-30 ◽  
Author(s):  
David BenEzra ◽  
Genia Maftzir ◽  
Ina Kalichman ◽  
Vivian Barak
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Interleukin 2 ◽  
Serum Levels ◽  
Behcet's Disease ◽  
Interleukin 2 Receptor

Serum levels of natriuretic peptides in patients with Behcet’s disease

2008 ◽  
Vol 27 (9) ◽  
pp. 1153-1158 ◽  
Author(s):  
Ramazan Yağcı ◽  
Yüksel Totan ◽  
Ekin Özlük ◽  
Hüseyin Özyurt ◽  
Gülfer Akbay ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Natriuretic Peptides ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Serum Levels ◽  
Behcet's Disease

scholarly journals High mobility group box 1 serum levels are increased in Behçet’s disease, but not associated with disease activity or disease manifestations

Rheumatology ◽  
2015 ◽  
pp. kev202 ◽  
Author(s):  
Alexandre W. S. de Souza ◽  
Sandro Félix Perazzio ◽  
Natália Regine de França ◽  
Luis Eduardo C. Andrade ◽  
Marc Bijl ◽  
...  
Keyword(s):  
Disease Activity ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
High Mobility ◽  
Serum Levels ◽  
High Mobility Group ◽  
Behcet's Disease
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