Thanatobiochemistry: post mortem study of the vitreous humor for the diagnosis of diabetic ketoacidosis death

2018 ◽  
Vol 76 (3) ◽  
pp. 245-250
Author(s):  
Guillaume Rousseau ◽  
Nicolas Bergerat ◽  
Guillaume Drevin ◽  
Pascal Reynier ◽  
Nathalie Jousset
Keyword(s):  
Diabetic Ketoacidosis ◽  
Vitreous Humor ◽  
Post Mortem

Analysis of hypoxanthine and lactic acid levels in vitreous humor for the estimation of post-mortem interval (PMI) using LC–MS/MS

2019 ◽  
Vol 299 ◽  
pp. 135-141 ◽  
Author(s):  
Ahra Go ◽  
Geunae Shim ◽  
Jiwon Park ◽  
Jinwoo Hwang ◽  
Mihyun Nam ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Vitreous Humor ◽  
Post Mortem ◽  
Post Mortem Interval

scholarly journals “2n Analytical Platform” To Update Procedures in Thanatochemistry: Estimation of Post Mortem Interval in Vitreous Humor

2019 ◽  
Vol 91 (11) ◽  
pp. 7025-7031 ◽  
Author(s):  
Roberta Risoluti ◽  
Silvia Canepari ◽  
Paola Frati ◽  
Vittorio Fineschi ◽  
Stefano Materazzi
Keyword(s):  
Vitreous Humor ◽  
Post Mortem ◽  
Post Mortem Interval

scholarly journals Ethanol Determination in Post-Mortem Samples: Correlation between Blood and Vitreous Humor Concentration

Molecules ◽  
2020 ◽  
Vol 25 (12) ◽  
pp. 2724
Author(s):  
Fabio Savini ◽  
Angela Tartaglia ◽  
Ludovica Coccia ◽  
Danilo Palestini ◽  
Cristian D’Ovidio ◽  
...  
Keyword(s):  
Whole Blood ◽  
Dynamic Range ◽  
Limit Of Detection ◽  
Linear Regression Analysis ◽  
Vitreous Humor ◽  
Alcohol Concentration ◽  
Coefficient Of Determination ◽  
Post Mortem ◽  
Excessive Alcohol Consumption ◽  
Ethanol Determination

Ethanol (ethylic alcohol) represents the most commonly used drug worldwide and is often involved in clinical and forensic toxicology. Based on several reports, excessive alcohol consumption is the main contributing factor in traffic accidents, drownings, suicides, and other crimes. For these reasons, it becomes essential to analyze the alcohol concentration during autopsy. Although blood is usually used for alcohol analysis in post-mortem cases, it could suffer alterations, putrefaction, and microbial contaminations. As an alternative to whole blood, vitreous humor has been successfully used in medico-legal studies. In this work, post-mortem specimens were analyzed for ethanol determination. The analysis of blood and vitreous humor were carried-out using gas chromatography-flame ionized detector (GC-FID) with a total run time of 6 min. The method was validated in terms of limit of detection, limit of quantification, dynamic range, sensibility, recovery, precision and trueness. A linear regression analysis indicated a coefficient of determination (R2) of 0.9981. The study confirmed no statistically differences between alcohol concentration in blood and vitreous humor, leading vitreous humor as an excellent matrix that could be used as an alternative to whole blood in toxicological analysis in cases where blood is not available.

Biochemical Differences Between Vitreous Humor and Cerebral Spinal Fluid in a Death From Diabetic Ketoacidosis

2019 ◽  
Vol 40 (2) ◽  
pp. 188-191 ◽  
Author(s):  
Jack Garland ◽  
Winston Philcox ◽  
Kilak Kesha ◽  
Sinead McCarthy ◽  
Leo Lam ◽  
...  
Keyword(s):  
Diabetic Ketoacidosis ◽  
Cerebral Spinal Fluid ◽  
Vitreous Humor ◽  
Spinal Fluid

Post mortem biochemistry differences between vitreous humor and cerebrospinal fluid

Pathology ◽  
2019 ◽  
Vol 51 ◽  
pp. S115
Author(s):  
Jack Garland ◽  
Winston Philcox ◽  
Sinead McCarthy ◽  
Kilak Kesha ◽  
Leo Lam ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Vitreous Humor ◽  
Post Mortem

Post-mortem changes in metabolomic profiles of human serum, aqueous humor and vitreous humor

Metabolomics ◽  
2020 ◽  
Vol 16 (7) ◽  
Author(s):  
Ekaterina A. Zelentsova ◽  
Lyudmila V. Yanshole ◽  
Arsenty D. Melnikov ◽  
Ivan S. Kudryavtsev ◽  
Vladimir P. Novoselov ◽  
...  
Keyword(s):  
Human Serum ◽  
Aqueous Humor ◽  
Vitreous Humor ◽  
Post Mortem

scholarly journals Case Report: Post-mortem Histopathological and Molecular Analyses of the Very First Documented COVID-19-Related Death in Europe

2021 ◽  
Vol 8 ◽  
Author(s):  
Milenko Bogdanović ◽  
Ivan Skadrić ◽  
Tatjana Atanasijević ◽  
Oliver Stojković ◽  
Vesna Popović ◽  
...  
Keyword(s):  
Case Report ◽  
Severe Acute Respiratory Syndrome ◽  
Unknown Origin ◽  
Vitreous Humor ◽  
Post Mortem ◽  
Molecular Analyses ◽  
First Case ◽  
The Republic

In Europe, the first case of coronavirus disease (COVID-19) and the first COVID-19-related death were reported in France on January 24th and February 15th, 2020, respectively. Officially, the first case of COVID-19 infection in the Republic of Serbia was registered on March 6th. Herein, we presented the first case of retrospective detection of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the post-mortem-obtained vitreous humor (VH), which took place on February 5th, 2020. This is the first death in Europe proven to be caused by COVID-19 by means of post-mortem histopathological and molecular analyses. Based on this finding, it appears that SARS-CoV-2 has been spreading faster and started spreading much earlier than it had been considered and that COVID-19 was probably the cause of the much-reported pneumonia of unknown origin in January and February 2020.

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