scholarly journals Roles of a Macrophage Receptor with Collagenous Structure(MARCO) in Host Defense and Heterogeneity of Splenic Marginal Zone Macrophages.

1999 ◽  
Vol 62 (1) ◽  
pp. 83-95 ◽  
Author(s):  
Shigeo ITO ◽  
Makoto NAITO ◽  
Yoshiaki KOBAYASHI ◽  
Hisakazu TAKATSUKA ◽  
Shuying JIANG ◽  
...  
Keyword(s):  
Host Defense ◽  
Marginal Zone ◽  
Collagenous Structure ◽  
Marginal Zone Macrophages

scholarly journals Cutting Edge: Marginal Zone Macrophages Regulate Antigen Transport by B Cells to the Follicle in the Spleen via CD21

2016 ◽  
Vol 197 (6) ◽  
pp. 2063-2068 ◽  
Author(s):  
Kajsa E. Prokopec ◽  
Anna-Maria Georgoudaki ◽  
Silke Sohn ◽  
Fredrik Wermeling ◽  
Hans Grönlund ◽  
...  
Keyword(s):  
B Cells ◽  
Marginal Zone ◽  
Cutting Edge ◽  
Antigen Transport ◽  
Marginal Zone Macrophages

scholarly journals Crucial role of Mer tyrosine kinase in the maintenance of SIGN-R1+ marginal zone macrophages

2018 ◽  
Vol 96 (3) ◽  
pp. 298-315
Author(s):  
Chetna Soni ◽  
Stephanie L Schell ◽  
Melinda J Fasnacht ◽  
Sathi Babu Chodisetti ◽  
Ziaur SM Rahman
Keyword(s):  
Tyrosine Kinase ◽  
Crucial Role ◽  
Marginal Zone ◽  
Mer Tyrosine Kinase ◽  
Marginal Zone Macrophages

scholarly journals Effects of lethal and non-lethal malaria on the mononuclear phagocyte system

1983 ◽  
Vol 16 (1) ◽  
pp. 58-67 ◽  
Author(s):  
Carlos Eduardo Tosta ◽  
Greta Ruiz ◽  
Nina Wedderburn
Keyword(s):  
Marginal Zone ◽  
Plasmodium Yoelii ◽  
Mononuclear Phagocyte ◽  
Mononuclear Phagocyte System ◽  
Phagocytic Cells ◽  
Terminal Stage ◽  
Haematopoietic Tissue ◽  
Red Pulp ◽  
Marginal Zone Macrophages

The effects ofone non-lethal species ofmalarialparasite, Plasmodium yoelii, and one lethal species, P. berghei, on the mononuclear phagocyte system (MPS) of BALB/c mice were studied. P. yoelii caused a greater and more sustained expansion and activation of the MPS, and the two major populations of spleen phagocytic cells-red pulp and marginal zone macrophages - exhibited a greater increase in numbers in this infection. During the course of P. berghei mataria, the spleen was progressively occupied by haematopoietic tissue and, at the terminal stage of infection, an extensive depletion of lymphocytes and macrophages was apparent. The possibility was suggested that the outcome of mataria may be inftuenced by the particular way the parasite interacts with the MPS.

Marginal zone macrophages express a murine homologue of DC-SIGN that captures blood-borne antigens in vivo

Blood ◽  
2002 ◽  
Vol 100 (8) ◽  
pp. 2908-2916 ◽  
Author(s):  
Teunis B. H. Geijtenbeek ◽  
Peter C. Groot ◽  
Martijn A. Nolte ◽  
Sandra J. van Vliet ◽  
Shanti T. Gangaram-Panday ◽  
...  
Keyword(s):  
Marginal Zone ◽  
Synapse Formation ◽  
Intercellular Adhesion Molecule ◽  
Pathogen Recognition ◽  
Liver Sinusoidal Endothelial Cells ◽  
Specific Polysaccharide ◽  
Murine Homologue ◽  
Encapsulated Bacteria ◽  
Marginal Zone Macrophages

Antigen-presenting cells are localized in essentially every tissue, where they operate at the interface of innate and acquired immunity by capturing pathogens and presenting pathogen-derived peptides to T cells. C-type lectins are important pathogen recognition receptors and the C-type lectin, dendritic cell–specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN), is unique in that, in addition to pathogen capture, it regulates adhesion processes such as DC trafficking and T-cell synapse formation. We have isolated a murine homologue of DC-SIGN that is identical to the previously reported murine homologue mSIGNR1. mSIGNR1 is more closely related to the human DC-SIGN homologue L-SIGN than to DC-SIGN itself because mSIGNR1 is specifically expressed by liver sinusoidal endothelial cells, similar to L-SIGN, and not by DCs. Moreover, mSIGNR1 is also expressed by medullary and subcapsular macrophages in lymph nodes and by marginal zone macrophages (MZMs) in the spleen. Strikingly, these MZMs are in direct contact with the bloodstream and efficiently capture specific polysaccharide antigens present on the surface of encapsulated bacteria. We have investigated the in vivo function of mSIGNR1 on MZMs in spleen. We demonstrate here that mSIGNR1 functions in vivo as a pathogen recognition receptor on MZMs that capture blood-borne antigens, which are rapidly internalized and targeted to lysosomes for processing. Moreover, the antigen capture is completely blocked in vivo by the blocking mSIGNR1-specific antibodies. Thus, mSIGNR1, a murine homologue of DC-SIGN, is important in the defense against pathogens and this study will facilitate further investigations into the in vivo function of DC-SIGN and its homologues.

Interaction of SIGNR1 expressed by marginal zone macrophages with marginal zone B cells is essential to early IgM responses against Streptococcus pneumoniae

2008 ◽  
Vol 45 (10) ◽  
pp. 2881-2887 ◽  
Author(s):  
Estella A. Koppel ◽  
Manja Litjens ◽  
Venice C. van den Berg ◽  
Yvette van Kooyk ◽  
Teunis B.H. Geijtenbeek
Keyword(s):  
Streptococcus Pneumoniae ◽  
B Cells ◽  
Marginal Zone ◽  
Marginal Zone B Cells ◽  
Marginal Zone Macrophages

scholarly journals Localization of Marginal Zone Macrophages Is Regulated by C-C Chemokine Ligands 21/19

2004 ◽  
Vol 173 (8) ◽  
pp. 4815-4820 ◽  
Author(s):  
Manabu Ato ◽  
Hideki Nakano ◽  
Terutaka Kakiuchi ◽  
Paul M. Kaye
Keyword(s):  
Marginal Zone ◽  
Chemokine Ligands ◽  
Marginal Zone Macrophages

scholarly journals Spleen deposition ofCryptococcus neoformanscapsular glucuronoxylomannan in rodents occurs in red pulp macrophages and not marginal zone macrophages expressing the C-type lectin SIGN-R1

2008 ◽  
Vol 46 (2) ◽  
pp. 153-162 ◽  
Author(s):  
Magdia De Jesus ◽  
Chae Gyu Park ◽  
Ya Su ◽  
David L. Goldman ◽  
Ralph M. Steinman ◽  
...  
Keyword(s):  
Marginal Zone ◽  
Red Pulp ◽  
Marginal Zone Macrophages

Splenic marginal-zone macrophages and marginal metallophils in rats and mice

1986 ◽  
Vol 246 (2) ◽  
pp. 263-269 ◽  
Author(s):  
Kenjiro Matsuno ◽  
Hirohiko Fujii ◽  
Masahiko Kotani
Keyword(s):  
Marginal Zone ◽  
Rats And Mice ◽  
Marginal Zone Macrophages
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