Role of parathyroid hormone-related peptide in hypercalcemia of malignancy and osteolytic bone disease

1998 ◽  
Vol 5 (1) ◽  
pp. 15-26 ◽  
Author(s):  
G R Mundy
Keyword(s):  
Parathyroid Hormone ◽  
Bone Disease ◽  
Hypercalcemia Of Malignancy ◽  
Related Peptide ◽  
Osteolytic Bone Disease ◽  
Parathyroid Hormone Related Peptide

scholarly journals Humoral Hypercalcemia of Malignancy with a Parathyroid Hormone-Related Peptide-Secreting Intrahepatic Cholangiocarcinoma Accompanied by a Gastric Cancer

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Katsushi Takeda ◽  
Ryosuke Kimura ◽  
Nobuhiro Nishigaki ◽  
Shinya Sato ◽  
Asami Okamoto ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Parathyroid Hormone ◽  
Intrahepatic Cholangiocarcinoma ◽  
Immunohistochemical Staining ◽  
Elevated Serum ◽  
Humoral Hypercalcemia Of Malignancy ◽  
Hypercalcemia Of Malignancy ◽  
Related Peptide ◽  
Humoral Hypercalcemia ◽  
Parathyroid Hormone Related Peptide

Humoral hypercalcemia of malignancy (HHM) is caused by the oversecretion of parathyroid hormone-related peptide (PTHrP) from malignant tumors. Although any tumor may cause HHM, that induced by intrahepatic cholangiocarcinoma (ICC) or gastric cancer (GC) is rare. We report here a 74-year-old male who displayed HHM with both ICC and GC and showed an elevated serum PTHrP level. Treatment of the hypercalcemia with saline, furosemide, elcatonin, and zoledronic acid corrected his serum calcium level and improved symptoms. Because treatment of ICC should precede that of GC, we chose chemotherapy with cisplatin (CDDP) and gemcitabine (GEM). Chemotherapy reduced the size of the ICC and decreased the serum PTHrP level. One year after diagnosis, the patient was alive in the face of a poor prognosis for an ICC that produced PTHrP. Immunohistochemical staining for PTHrP was positive for the ICC and negative for the GC, leading us to believe that the cause of the HHM was a PTHrP-secreting ICC. In conclusion, immunohistochemical staining for PTHrP may be useful in discovering the cause of HHM in the case of two cancers accompanied by an elevated serum PHTrP level. Chemotherapy with CDDP and GEM may be the most appropriate treatment for a PTHrP-secreting ICC.

Role of bone and kidney in parathyroid hormone-related peptide-induced hypercalcemia in rats

2009 ◽  
Vol 4 (5) ◽  
pp. 759-765 ◽  
Author(s):  
René Rizzoli ◽  
J. Caverzasio ◽  
M.C. Chapuy ◽  
T.J. Martin ◽  
J.P. Bonjour
Keyword(s):  
Parathyroid Hormone ◽  
Related Peptide ◽  
Parathyroid Hormone Related Peptide
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