Role of Dual Signal Transduction Systems in the Stimulation of Bone Resorption by Parathyroid Hormone-Related Peptide

1993 ◽  
Vol 25 (08) ◽  
pp. 421-424 ◽  
Author(s):  
H. Kaji ◽  
T. Sugimoto ◽  
M. Fukase ◽  
K. Chihara
Keyword(s):  
Signal Transduction ◽  
Parathyroid Hormone ◽  
Bone Resorption ◽  
Related Peptide ◽  
Parathyroid Hormone Related Peptide ◽  
Stimulation Of ◽  
Signal Transduction Systems

Plasma parathyroid hormone-related peptide and bone metabolism in periparturient dairy cows

2008 ◽  
Vol 56 (2) ◽  
pp. 235-244 ◽  
Author(s):  
Natalija Filipović ◽  
Zvonko Stojević ◽  
Maja Zdelar-Tuk ◽  
Vesna Kušec
Keyword(s):  
Parathyroid Hormone ◽  
Bone Resorption ◽  
Dairy Cows ◽  
Bone Metabolism ◽  
Type I Collagen ◽  
Type I ◽  
Bone Specific Alkaline Phosphatase ◽  
Related Peptide ◽  
Parathyroid Hormone Related Peptide

The first weeks of lactation in dairy cows are characterised by elevated bone resorption. The connection between lactation and bone metabolism is still much discussed. In this work, changes in the concentration of plasma parathyroid hormone-related peptide (PTHrP) and markers of bone metabolism were studied in Holstein cows and heifers in the dry period and early lactation to determine the role of PTHrP in the relationship between the rate of bone remodelling and the onset of lactation in dairy cows. Blood samples were taken 14 days before calving (‘D-14’, n = 23) and then on day 10 (‘D+10’, n = 21) and day 30 after calving (‘D+30’, n = 23). Using enzyme immunoassay (EIA), the concentrations of PTHrP, parathyroid hormone (PTH), carboxyterminal cross-linked telopeptide of type I collagen (CTX) and oestradiol and the activity of bone specific alkaline phosphatase (BSALP) were determined. The results showed a statistically significant increase in plasma PTHrP (p < 0.005) and CTX (p < 0.0001) in cows on ‘D+10’ as compared to ‘D-14’ and CTX on ‘D+30’ as compared to ‘D-14’ (p < 0.0001). Significant negative correlations were found between the concentrations of PTHrP and oestradiol (r = −0.29, p < 0.05) and those of CTX and oestradiol (r = −0.54, p < 0.0001). In nonpregnant heifers (n = 6), the concentration of CTX and the activity of BSALP were significantly higher (p < 0.0001) than in dry cows. The observed increments of PTHrP and bone resorption after parturition reveal adaptations of bone metabolism to lactation in dairy cows.

Role of bone and kidney in parathyroid hormone-related peptide-induced hypercalcemia in rats

2009 ◽  
Vol 4 (5) ◽  
pp. 759-765 ◽  
Author(s):  
René Rizzoli ◽  
J. Caverzasio ◽  
M.C. Chapuy ◽  
T.J. Martin ◽  
J.P. Bonjour
Keyword(s):  
Parathyroid Hormone ◽  
Related Peptide ◽  
Parathyroid Hormone Related Peptide
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