scholarly journals Metabolic syndrome, plasma lipid, lipoprotein and glucose levels, and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)

2007 ◽  
Vol 14 (3) ◽  
pp. 755-767 ◽  
Author(s):  
Anne E Cust ◽  
Rudolf Kaaks ◽  
Christine Friedenreich ◽  
Fabrice Bonnet ◽  
Martine Laville ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Endometrial Cancer ◽  
Waist Circumference ◽  
Cancer Risk ◽  
Density Lipoprotein ◽  
Metabolic Factors ◽  
Endometrial Cancer Risk ◽  
Glucose Levels ◽  
Bottom Quartile ◽  
Prospective Investigation

To clarify the role of metabolic factors in endometrial carcinogenesis, we conducted a case–control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), and examined the relation between prediagnostic plasma lipids, lipoproteins, and glucose, the metabolic syndrome (MetS; a cluster of metabolic factors) and endometrial cancer risk. Among pre- and postmenopausal women, 284 women developed endometrial cancer during follow-up. Using risk set sampling, 546 matched control subjects were selected. From conditional logistic regression models, high-density lipoprotein cholesterol (HDL-C) levels were inversely associated with risk body mass index (BMI)-adjusted relative risk (RR) for top versus bottom quartile 0.61 (95% confidence intervals (CI) 0.38–0.97), Ptrend = 0.02). Glucose levels were positively associated with risk (BMI-adjusted RR top versus bottom quartile 1.69 (95% CI 0.99–2.90), Ptrend = 0.03), which appeared stronger among postmenopausal women (BMI-adjusted RR top versus bottom tertile 2.61 (95% CI 1.46–4.66), Ptrend = 0.0006, Pheterogeneity = 0.13) and never-users of exogenous hormones (Pheterogeneity = 0.005 for oral contraceptive (OC) use and 0.05 for hormone replacement therapy-use). The associations of HDL-C and glucose with risk were no longer statistically significant after further adjustment for obesity-related hormones. Plasma total cholesterol, Low-density lipoprotein cholesterol (LDL-C), and triglycerides were not significantly related to overall risk. The presence of MetS was associated with risk (RR 2.12 (95% CI 1.51–2.97)), which increased with the number of MetS factors (Ptrend = 0.02). An increasing number of MetS factors other than waist circumference, however, was marginally significantly associated with risk only in women with waist circumference above the median (Pinteraction = 0.01). None of the associations differed significantly by fasting status. These findings suggest that metabolic abnormalities and obesity may act synergistically to increase endometrial cancer risk.

scholarly journals Dietary intake of acrylamide and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort

2014 ◽  
Vol 111 (5) ◽  
pp. 987-997 ◽  
Author(s):  
M Obón-Santacana ◽  
R Kaaks ◽  
N Slimani ◽  
L Lujan-Barroso ◽  
H Freisling ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cancer Risk ◽  
Dietary Intake ◽  
Endometrial Cancer Risk ◽  
Prospective Investigation

scholarly journals Association of Metabolic Factors with Essential Hypertension

2011 ◽  
Vol 24 (1) ◽  
pp. 21-25
Author(s):  
N Rahman Khandaker ◽  
Akhtaruzzaman ◽  
K Rahat Mahfuz ◽  
AR Khandakar ◽  
MMR Khan ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Waist Circumference ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Metabolic Factors ◽  
College Hospital ◽  
High Waist Circumference ◽  
Increased Risk ◽  
Low Hdl

Background-Metabolic syndrome is a risk factor for cardiovascular disease, so it should call attention. South Asian person has preponderance to it. Objectives-The proper findings of metabolic syndrome are a key to prevent cardiovascular disease. Hypertension is a component of metabolic syndrome with which patients are at increased risk for cardiovascular disease. Methods-This study was carried out in cardiology outdoor of Shaheed Suhrawardy medical college hospital, Dhaka. A total of 322 patients were enrolled from January 2008 to December 2010. Metabolic syndrome was defined as three of the followings: (a) Abnormal fasting serum level of glucose (≥110 mg/dl or 6.1 mmol/L), ( b) abdominal obesity (waist circumference >102 cm in men and >88 cm in women), (c) Triglycerides (≥150 mg/dl), (d) High density lipoprotein cholesterol (<40 mg/dl in men and <50 mg/dl in woman), (e) Hypertension, which was common in all patients. Results- Among hypertensive’s patients 31.8% had hyperglycemia, 37.9% had high waist circumference, 69.8% had low HDL cholesterol and 54.3% high triglycerides. As per definition of NCEP-ATP-III, metabolic syndrome had been detected in 17% of male, 37% of female and 27% of the total population. Conclusion- Metabolic factors are a common association in hypertensive cases. These patients are at increased risk of coronary and cerebro-vascular disease and require more vigorous prevention. Furthermore in all hypertensive patients metabolic screening is recommended. TAJ 2011; 24(1): 21-25

scholarly journals Obesity, inflammatory markers, and endometrial cancer risk: a prospective case–control study

2010 ◽  
Vol 17 (4) ◽  
pp. 1007-1019 ◽  
Author(s):  
Laure Dossus ◽  
Sabina Rinaldi ◽  
Susen Becker ◽  
Annekatrin Lukanova ◽  
Anne Tjonneland ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cancer Risk ◽  
Inflammatory Markers ◽  
Case Control Study ◽  
Case Control ◽  
Low Grade ◽  
Endometrial Cancer Risk ◽  
Bottom Quartile ◽  
Incident Cases ◽  
Control Study

Obesity, a major risk factor for endometrial cancer, is a low-grade inflammatory state characterized by elevated concentrations of cytokines and acute phase reactants. The current study had two aims: first to investigate the associations of C-reactive protein (CRP), interleukin 6 (IL6), and IL1 receptor antagonist (IL1Ra) with endometrial cancer risk and second to examine to which extent these markers can influence the association between obesity and endometrial cancer. We conducted a case–control study, nested within the European Prospective Investigation into Cancer and Nutrition, which comprised 305 incident cases of endometrial cancer and 574 matched controls. CRP, IL6, and IL1Ra were measured in prospectively collected blood specimens by immunoassays. Data were analyzed using conditional logistic regression. All statistical tests were two-sided, and P values <0.05 were considered statistically significant. We observed a significant increase in risk of endometrial cancer with elevated levels of CRP (odds ratio (OR) for top versus bottom quartile: 1.58, 95% confidence interval (CI): 1.03–2.41, Ptrend=0.02), IL6 (OR for top versus bottom quartile: 1.66, 95% CI: 1.08–2.54, Ptrend=0.008), and IL1Ra (OR for top versus bottom quartile: 1.82, 95% CI: 1.22–2.73, Ptrend=0.004). After adjustment for body mass index (BMI), the estimates were strongly reduced and became non-significant. The association between BMI and endometrial cancer was also substantially attenuated (∼10–20%) after adjustment for inflammatory markers, even when the effects of C-peptide or estrone had already been taken into account. We provided epidemiological evidence that chronic inflammation might mediate the association between obesity and endometrial cancer and that endometrial carcinogenesis could be promoted by an inflammatory milieu.

scholarly journals Metabolic syndrome and endometrial cancer risk

2011 ◽  
Vol 22 (4) ◽  
pp. 884-889 ◽  
Author(s):  
V. Rosato ◽  
A. Zucchetto ◽  
C. Bosetti ◽  
L. Dal Maso ◽  
M. Montella ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Endometrial Cancer ◽  
Cancer Risk ◽  
Endometrial Cancer Risk

Alcohol drinking and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

2013 ◽  
Vol 23 (2) ◽  
pp. 93-98 ◽  
Author(s):  
Veronika Fedirko ◽  
Mazda Jenab ◽  
Sabina Rinaldi ◽  
Carine Biessy ◽  
Naomi E. Allen ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cancer Risk ◽  
Alcohol Drinking ◽  
Endometrial Cancer Risk ◽  
Prospective Investigation

scholarly journals Serum levels of C-peptide, IGFBP-1 and IGFBP-2 and endometrial cancer risk; Results from the European prospective investigation into cancer and nutrition

2007 ◽  
Vol 120 (12) ◽  
pp. 2656-2664 ◽  
Author(s):  
Anne E. Cust ◽  
Naomi E. Allen ◽  
Sabina Rinaldi ◽  
Laure Dossus ◽  
Christine Friedenreich ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cancer Risk ◽  
Serum Levels ◽  
Endometrial Cancer Risk ◽  
C Peptide ◽  
Prospective Investigation
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