scholarly journals Serum levels of C-peptide, IGFBP-1 and IGFBP-2 and endometrial cancer risk; Results from the European prospective investigation into cancer and nutrition

2007 ◽  
Vol 120 (12) ◽  
pp. 2656-2664 ◽  
Author(s):  
Anne E. Cust ◽  
Naomi E. Allen ◽  
Sabina Rinaldi ◽  
Laure Dossus ◽  
Christine Friedenreich ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cancer Risk ◽  
Serum Levels ◽  
Endometrial Cancer Risk ◽  
C Peptide ◽  
Prospective Investigation

scholarly journals Dietary intake of acrylamide and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort

2014 ◽  
Vol 111 (5) ◽  
pp. 987-997 ◽  
Author(s):  
M Obón-Santacana ◽  
R Kaaks ◽  
N Slimani ◽  
L Lujan-Barroso ◽  
H Freisling ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cancer Risk ◽  
Dietary Intake ◽  
Endometrial Cancer Risk ◽  
Prospective Investigation

scholarly journals Obesity-related hormones and endometrial cancer among postmenopausal women: a nested case–control study within the B∼FIT cohort

2012 ◽  
Vol 20 (1) ◽  
pp. 151-160 ◽  
Author(s):  
Cher M Dallal ◽  
Louise A Brinton ◽  
Douglas C Bauer ◽  
Diana S M Buist ◽  
Jane A Cauley ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cancer Risk ◽  
Postmenopausal Women ◽  
Case Control Study ◽  
Case Control ◽  
Endometrial Cancer Risk ◽  
C Peptide ◽  
Hmw Adiponectin ◽  
Control Study

Endometrial cancer risk is strongly influenced by obesity, but the mechanisms of action remain unclear. Leptin and adiponectin, secreted from adipose tissue, reportedly play a role in such carcinogenic processes as cell proliferation, angiogenesis, and insulin regulation. In this case–control study, nested within the Breast and Bone Follow-up of the Fracture Intervention Trial (n=15 595), we assessed pre-diagnostic serum leptin, total adiponectin, and high-molecular-weight (HMW) adiponectin in relation to endometrial cancer among postmenopausal women. During the 10-year follow-up, 62 incident endometrial cases were identified and matched to 124 controls on age, geographical site, time of fasting blood draw at baseline (1992–1993), and trial participation status. Adipokines and C-peptide were measured by ELISA. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were estimated via conditional logistic regression, with exposures categorized in tertiles (T). Multivariable models considered C-peptide, BMI (kg/m2), and estradiol (E2) as potential confounders. Endometrial cancer risk was significantly associated with higher leptin levels, adjusted for E2 and C-peptide (ORT3 vs T1=2.96; 95% CI, 1.21–7.25; P trend <0.01). After further adjustment for BMI, the estimates were attenuated and the positive trend was no longer statistically significant (ORT3 vs T1=2.11; 95% CI, 0.69–6.44; P trend=0.18). No significant associations were observed with adiponectin or HMW adiponectin and endometrial cancer. Our findings with leptin suggest that the leptin–BMI axis might increase endometrial cancer risk through mechanisms other than estrogen-driven proliferation. Continued exploration of these pathways in larger prospective studies may help elucidate mechanisms underlying observed obesity–endometrial cancer associations.

scholarly journals Metabolic syndrome, plasma lipid, lipoprotein and glucose levels, and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)

2007 ◽  
Vol 14 (3) ◽  
pp. 755-767 ◽  
Author(s):  
Anne E Cust ◽  
Rudolf Kaaks ◽  
Christine Friedenreich ◽  
Fabrice Bonnet ◽  
Martine Laville ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Endometrial Cancer ◽  
Waist Circumference ◽  
Cancer Risk ◽  
Density Lipoprotein ◽  
Metabolic Factors ◽  
Endometrial Cancer Risk ◽  
Glucose Levels ◽  
Bottom Quartile ◽  
Prospective Investigation

To clarify the role of metabolic factors in endometrial carcinogenesis, we conducted a case–control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), and examined the relation between prediagnostic plasma lipids, lipoproteins, and glucose, the metabolic syndrome (MetS; a cluster of metabolic factors) and endometrial cancer risk. Among pre- and postmenopausal women, 284 women developed endometrial cancer during follow-up. Using risk set sampling, 546 matched control subjects were selected. From conditional logistic regression models, high-density lipoprotein cholesterol (HDL-C) levels were inversely associated with risk body mass index (BMI)-adjusted relative risk (RR) for top versus bottom quartile 0.61 (95% confidence intervals (CI) 0.38–0.97), Ptrend = 0.02). Glucose levels were positively associated with risk (BMI-adjusted RR top versus bottom quartile 1.69 (95% CI 0.99–2.90), Ptrend = 0.03), which appeared stronger among postmenopausal women (BMI-adjusted RR top versus bottom tertile 2.61 (95% CI 1.46–4.66), Ptrend = 0.0006, Pheterogeneity = 0.13) and never-users of exogenous hormones (Pheterogeneity = 0.005 for oral contraceptive (OC) use and 0.05 for hormone replacement therapy-use). The associations of HDL-C and glucose with risk were no longer statistically significant after further adjustment for obesity-related hormones. Plasma total cholesterol, Low-density lipoprotein cholesterol (LDL-C), and triglycerides were not significantly related to overall risk. The presence of MetS was associated with risk (RR 2.12 (95% CI 1.51–2.97)), which increased with the number of MetS factors (Ptrend = 0.02). An increasing number of MetS factors other than waist circumference, however, was marginally significantly associated with risk only in women with waist circumference above the median (Pinteraction = 0.01). None of the associations differed significantly by fasting status. These findings suggest that metabolic abnormalities and obesity may act synergistically to increase endometrial cancer risk.

Alcohol drinking and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

2013 ◽  
Vol 23 (2) ◽  
pp. 93-98 ◽  
Author(s):  
Veronika Fedirko ◽  
Mazda Jenab ◽  
Sabina Rinaldi ◽  
Carine Biessy ◽  
Naomi E. Allen ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cancer Risk ◽  
Alcohol Drinking ◽  
Endometrial Cancer Risk ◽  
Prospective Investigation

Endometrial cancer risk after fertility treatment: a population-based cohort study

2021 ◽  
Author(s):  
Sonia Guleria ◽  
Allan Jensen ◽  
Vanna Albieri ◽  
Bugge Nøhr ◽  
Kirsten Frederiksen ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cohort Study ◽  
Cancer Risk ◽  
Population Based ◽  
Fertility Treatment ◽  
Endometrial Cancer Risk
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