scholarly journals The LET Dependence of Unrepaired Chromosome Damage in Human Cells: A Break Too Far?

2013 ◽  
pp. 130222085209009
Author(s):  
Bradford D. Loucas ◽  
Michael N. Cornforth
Keyword(s):  
Human Cells ◽  
Chromosome Damage

scholarly journals Chromosome Damage in Human Cells by γ Rays, α Particles and Heavy Ions: Track Interactions in Basic Dose-Response Relationships

2012 ◽  
Vol 179 (1) ◽  
pp. 9 ◽  
Author(s):  
Bradford D. Loucas ◽  
Marco Durante ◽  
Susan M. Bailey ◽  
Michael N. Cornforth
Keyword(s):  
Dose Response ◽  
Heavy Ions ◽  
Human Cells ◽  
Chromosome Damage ◽  
Γ Rays ◽  
Α Particles

Investigation of chromosome damage in human cells irradiated by beam for proton therapy produced by phasotron at the joint institute for nuclear research

2006 ◽  
Vol 3 (1) ◽  
pp. 54-58 ◽  
Author(s):  
R. D. Govorun ◽  
M. Deperas-Kaminska ◽  
E. M. Zaitseva ◽  
E. A. Krasavin ◽  
G. V. Mitsyn ◽  
...  
Keyword(s):  
Proton Therapy ◽  
Nuclear Research ◽  
Human Cells ◽  
Joint Institute ◽  
Chromosome Damage

scholarly journals The LET Dependence of Unrepaired Chromosome Damage in Human Cells: A Break Too Far?

2013 ◽  
Vol 179 (4) ◽  
pp. 393-405 ◽  
Author(s):  
Bradford D. Loucas ◽  
Michael N. Cornforth
Keyword(s):  
Human Cells ◽  
Chromosome Damage

Effect of Thiol Compounds on Bleomycin-Induced DNA and Chromosome Damage in Human Cells

2013 ◽  
Vol 68 (2) ◽  
pp. 107-116 ◽  
Author(s):  
Anabela Mira ◽  
Esteban M. Gimenez ◽  
Alejandro D. Bolzán ◽  
Martha S. Bianchi ◽  
Daniel M. López-Larraza
Keyword(s):  
Human Cells ◽  
Chromosome Damage ◽  
Thiol Compounds

Alpha-Tocopherol Protects Cultured Human Cells from the Acute Lethal Cytotoxicity of Dioxin

2002 ◽  
Vol 72 (3) ◽  
pp. 147-153 ◽  
Author(s):  
Kei-Ichi Hirai ◽  
Jie-Hong Pan ◽  
Ying-Bo Shui ◽  
Eriko Simamura ◽  
Hiroki Shimada ◽  
...  
Keyword(s):  
Cell Death ◽  
Cell Damage ◽  
Smooth Endoplasmic Reticulum ◽  
Dehydroascorbic Acid ◽  
Human Cells ◽  
Alpha Tocopherol ◽  
Cervical Cancer Cells ◽  
Cultured Human Cells ◽  
Nuclear Damage ◽  
Conjunctival Epithelial Cells

The possible protection of cultured human cells from acute dioxin injury by antioxidants was investigated. The most potent dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), caused vacuolization of the smooth endoplasmic reticulum and Golgi apparatus in cultured human conjunctival epithelial cells and cervical cancer cells. Subsequent nuclear damage included a deep irregular indentation resulting in cell death. A dosage of 30–40 ng/mL TCDD induced maximal intracellular production of H2O2 at 30 minutes and led to severe cell death (0–31% survival) at two hours. A dose of 1.7 mM alpha-tocopherol or 1 mM L-dehydroascorbic acid significantly protected human cells against acute TCDD injuries (78–97% survivals), but vitamin C did not provide this protection. These results indicate that accidental exposure to fatal doses of TCDD causes cytoplasmic free radical production within the smooth endoplasmic reticular systems, resulting in severe cytotoxicity, and that vitamin E and dehydroascorbic acid can protect against TCDD-induced cell damage.

Chromium oxidation state mapping in human cells

2003 ◽  
Vol 104 ◽  
pp. 289-292 ◽  
Author(s):  
R. Ortega ◽  
B. Fayard ◽  
M. Salomé ◽  
G. Devès ◽  
J. Susini
Keyword(s):  
Oxidation State ◽  
Human Cells ◽  
Chromium Oxidation

Transport of clozapine and its major metabolites into human cells of glial and neuronal origin

2004 ◽  
Vol 36 (05) ◽  
Author(s):  
U Henning ◽  
K Krieger ◽  
S Loeffler ◽  
A Klimke
Keyword(s):  
Human Cells

Lineage conversion of human cells to an adrenocortical phenotype: a new technology to study the adrenal gland

2015 ◽  
Author(s):  
Gerard Ruiz Babot ◽  
Irene Hadjidemetriou ◽  
Sharon Jane Ajodha ◽  
David Taylor ◽  
Norman Taylor ◽  
...  
Keyword(s):  
Adrenal Gland ◽  
New Technology ◽  
Human Cells
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