Detection of Partial-Body Exposure to Ionizing Radiation by the Automatic Detection of Dicentrics

2012 ◽  
Vol 178 (4) ◽  
pp. 357-364 ◽  
Author(s):  
Aurelie Vaurijoux ◽  
Eric Gregoire ◽  
Sandrine Roch-Lefevre ◽  
Pascale Voisin ◽  
Cecile Martin ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Automatic Detection ◽  
Partial Body

scholarly journals Biological Dosimetry Using Micronucleus Assay in Simulated Partial-Body Exposure to Ionizing Radiation

2017 ◽  
Vol 43 (2) ◽  
pp. 75 ◽  
Author(s):  
S. Purnami ◽  
S. Nurhayati ◽  
M. Syaifudin ◽  
D. Ramadhani
Keyword(s):  
Ionizing Radiation ◽  
Micronucleus Assay ◽  
Biological Dosimetry ◽  
Partial Body

scholarly journals Estimating partial-body ionizing radiation exposure by automated cytogenetic biodosimetry

2020 ◽  
Vol 96 (11) ◽  
pp. 1492-1503
Author(s):  
Ben C. Shirley ◽  
Joan H. M. Knoll ◽  
Jayne Moquet ◽  
Elizabeth Ainsbury ◽  
Ngoc-Duy Pham ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Radiation Exposure ◽  
Partial Body ◽  
Ionizing Radiation Exposure

scholarly journals Estimating partial body ionizing radiation exposure by automated cytogenetic biodosimetry

2020 ◽  
Author(s):  
Ben C. Shirley ◽  
Joan H.M. Knoll ◽  
Jayne Moquet ◽  
Elizabeth Ainsbury ◽  
Pham Ngoc Duy ◽  
...  
Keyword(s):  
Public Health ◽  
Ionizing Radiation ◽  
False Positive ◽  
Nuclear Research ◽  
Whole Body ◽  
Nuclear Research Institute ◽  
Research Scientist ◽  
School Of Medicine ◽  
Partial Body ◽  
Calibration Samples

AbstractPurposeInhomogeneous exposures to ionizing radiation can be detected and quantified with the Dicentric Chromosome Assay (DCA) of metaphase cells. Complete automation of interpretation of the DCA for whole body irradiation has significantly improved throughput without compromising accuracy, however low levels of residual false positive dicentric chromosomes (DCs) have confounded its application for partial body exposure determination.Materials and MethodsWe describe a method of estimating and correcting for false positive DCs in digitally processed images of metaphase cells. Nearly all DCs detected in unirradiated calibration samples are introduced by digital image processing. DC frequencies of irradiated calibration samples and those exposed to unknown radiation levels are corrected subtracting this false positive fraction from each. In partial body exposures, the fraction of cells exposed, and radiation dose can be quantified after applying this modification of the contaminated Poisson method.ResultsDose estimates of three partially irradiated samples diverged 0.2 to 2.5 Gy from physical doses and irradiated cell fractions deviated by 2.3-15.8% from the known levels. Synthetic partial body samples comprised of unirradiated and 3 Gy samples from 4 laboratories were correctly discriminated as inhomogeneous by multiple criteria. Root mean squared errors of these dose estimates ranged from 0.52 to 1.14 Gy2 and from 8.1 to 33.3%2 for the fraction of cells irradiated.ConclusionsAutomated DCA can differentiate whole-from partial-body radiation exposures and provides timely quantification of estimated whole-body equivalent dose.Biographical NoteBen Shirley M.Sc. is Chief Software Architect, CytoGnomix Inc. Canada; Joan Knoll Ph.D. Dipl.ABMGG, FCCMG is Professor in Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, Canada and cofounder, CytoGnomix Inc.; Jayne Moquet Ph.D. is Principal Radiation Protection Scientist in the Cytogenetics Group, Public Health England; Elizabeth Ainsbury Ph.D. is Head, Cytogenetics Group and the Chromosome Dosimetry Service, Public Health England; Pham Ngoc Duy M.Sc. is deputy director of Biotechnology Center, Dalat Nuclear Research Institute, Vietnam; Farrah Norton M.Sc.is Research Scientist and Lead of the Biodosimetry emergency response and research capability at Canadian Nuclear Laboratories; Ruth Wilkins, Ph.D. is Research Scientist and Chief of the Ionizing Radiation Health Sciences Division at Health Canada, Ontario, Canada; and Peter K. Rogan Ph.D. is Professor of Biochemistry and Oncology, Schulich School of Medicine and Dentistry, University of Western Ontario, Canada, and President, CytoGnomix Inc.

Radiation-induced surface decomposition

1983 ◽  
Vol 41 ◽  
pp. 368-369
Author(s):  
M. L. Knotek
Keyword(s):  
Ionizing Radiation ◽  
Atomic Structure ◽  
Chemical Bonding ◽  
Neutral Species ◽  
Radiation Induced ◽  
Physical And Chemical ◽  
Surface Decomposition ◽  
The Relationship ◽  
Electron And Photon ◽  
Surface Bond

Modern surface analysis is based largely upon the use of ionizing radiation to probe the electronic and atomic structure of the surfaces physical and chemical makeup. In many of these studies the ionizing radiation used as the primary probe is found to induce changes in the structure and makeup of the surface, especially when electrons are employed. A number of techniques employ the phenomenon of radiation induced desorption as a means of probing the nature of the surface bond. These include Electron- and Photon-Stimulated Desorption (ESD and PSD) which measure desorbed ionic and neutral species as they leave the surface after the surface has been excited by some incident ionizing particle. There has recently been a great deal of activity in determining the relationship between the nature of chemical bonding and its susceptibility to radiation damage.

Sign in / Sign up

Export Citation Format

Share Document