Translocation Frequency in Patients with Repeated CT Exposure: Comparison with CT-Naive Patients

2019 ◽  
Vol 192 (1) ◽  
pp. 23 ◽  
Author(s):  
Jin Kyung Lee ◽  
Myoung Seok Lee ◽  
Min Hoan Moon ◽  
Hyunsik Woo ◽  
Young Jun Hong ◽  
...  
Keyword(s):  
Translocation Frequency

scholarly journals Retrospective biodosimetry using translocation frequency in a stable cell of occupationally exposed to ionizing radiation

2015 ◽  
Vol 56 (4) ◽  
pp. 709-716 ◽  
Author(s):  
Min Su Cho ◽  
Jin Kyung Lee ◽  
Keum Seok Bae ◽  
Eun-Ae Han ◽  
Seong Jae Jang ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Occupationally Exposed ◽  
Translocation Frequency

scholarly journals Translocation frequency of double-stranded DNA through a solid-state nanopore

2016 ◽  
Vol 93 (2) ◽  
Author(s):  
Nicholas A. W. Bell ◽  
Murugappan Muthukumar ◽  
Ulrich F. Keyser
Keyword(s):  
Solid State ◽  
Double Stranded Dna ◽  
Translocation Frequency

scholarly journals High dietary niacin intake is associated with decreased chromosome translocation frequency in airline pilots

2010 ◽  
Vol 105 (4) ◽  
pp. 496-505 ◽  
Author(s):  
Lee C. Yong ◽  
Martin R. Petersen
Keyword(s):  
Dna Damage ◽  
Whole Grains ◽  
B Vitamins ◽  
Processed Meat ◽  
Vitamin B ◽  
Airline Pilots ◽  
Translocation Frequency ◽  
Adjusted Rate ◽  
Rate Ratios ◽  
Red And Processed Meat

Experimental studies suggest that B vitamins such as niacin, folate, riboflavin, vitamin B6 and vitamin B12 may protect against DNA damage induced by ionising radiation (IR). However, to date, data from IR-exposed human populations are not available. We examined the intakes of these B vitamins and their food sources in relation to the frequency of chromosome translocations as a biomarker of cumulative DNA damage, in eighty-two male airline pilots. Dietary intakes were estimated by using a self-administered semi-quantitative FFQ. Translocations in peripheral blood lymphocytes were scored by using fluorescence in situ hybridisation whole-chromosome painting. Negative binomial regression was used to estimate rate ratios and 95 % CI, adjusted for age and occupational and lifestyle factors. We observed a significant inverse association between translocation frequency and dietary intake of niacin (P = 0·02): adjusted rate ratio for subjects in the highest tertile compared with the lowest tertile was 0·58 (95 % CI 0·40, 0·83). Translocation frequency was not associated with total niacin intake from food and supplements as well as dietary or total intake of folate, riboflavin or vitamin B6 or B12. However, the adjusted rate ratios were significant for subjects with ≥ median compared with < median intake of whole grains (P = 0·03) and red and processed meat (P = 0·01): 0·69 (95 % CI 0·50, 0·96) and 1·56 (95 % CI 1·13, 2·16), respectively. Our data suggest that a high intake of niacin from food or a diet high in whole grains but low in red and processed meat may protect against cumulative DNA damage in IR-exposed persons.

Dose-Response Curve for Translocation Frequency with Single Pair of Painted Chromosome. A Comparison with Dicentric and Micronuclei Frequency

2000 ◽  
Vol 87 (2) ◽  
pp. 101-108 ◽  
Author(s):  
P. Venkatachalam ◽  
S.F.D. Paul ◽  
M.N. Mohankumar ◽  
B.K. Prabhu ◽  
N. Gajendiran ◽  
...  
Keyword(s):  
Dose Response ◽  
Response Curve ◽  
Dose Response Curve ◽  
Single Pair ◽  
Painted Chromosome ◽  
Translocation Frequency

A possible genetic method for the control of insect pests, with special reference to tsetse flies (Glossina spp.)

1968 ◽  
Vol 57 (4) ◽  
pp. 509-523 ◽  
Author(s):  
C. F. Curtis
Keyword(s):  
Insect Pests ◽  
Tsetse Flies ◽  
Adult Males ◽  
Homologous Chromosomes ◽  
Genetic Method ◽  
Chromosome Translocations ◽  
Large Numbers ◽  
Translocation Frequency ◽  
Successive Generations ◽  
Number Of Individuals

The use of chromosome translocations for the control of pests, with particular reference to Glossina, is proposed. A translocation arises if two non-homologous chromosomes in the same cell undergo breakage and the fragments re-join with the wrong partners. At meiosis in an individual heterozygous for a translocation, gamete nuclei with several different combinations of chromosomes are produced. Some of these are diploid for one part and lack completely another part of the normal chromosome set; when such unbalanced gametes fertilise normal gametes inviable embryos are produced. It has been found in a number of organisms that about half the gametes of translocation heterozygotes are of the unbalanced type and such heterozygotes are described as semi-sterile. If an individual inherits the same translocation from both parents it is described as a translocation homozygote; this is often inviable but, if not, its fertility is usually normal.Adult males of G. austeni Newst. have been irradiated and each of their progeny are being screened for the occurrence of semi-sterility. Any individuals found to be semi-sterile would probably be translocation heterozygotes and their progeny will be inbred to try to produce a viable stock, homozygous for a translocation. If this can be done, large numbers of such translocation homozygotes could be reared and released into a wild population, where matings with wild types would produce heterozygotes, and hence a reduction in the fertility of the population.Using simple assumptions, the effects of releasing translocation homozygotes were computed. Provided the numbers released were such that the translocation frequency approached the optimum value of 50 per cent., the reduction in population fertility would be prolonged for many generations after the releases had finished. It is shown that it would be more efficient to release the translocation homozygotes at successive generations rather than all at once and that the homozygotes released could with advantage be of both sexes. For this reason, and because of the prolonged effect of releases of translocations, it is concluded that the number of individuals that would have to be reared to achieve a given result by the translocation method might be considerably less than if the sterile-male method was used. However, the reduction in population fertility at each generation that can be achieved with the translocation method is limited, and the method would therefore be ineffective against populations whose size was strongly buffered by density-dependent factors.

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