scholarly journals Irradiation at Different Fetal Stages Results in Different Translocation Frequencies in Adult Mouse Thyroid Cells

2016 ◽  
Vol 186 (4) ◽  
pp. 360 ◽  
Author(s):  
K. Hamasaki ◽  
R. D. Landes ◽  
A. Noda ◽  
N. Nakamura ◽  
Y. Kodama
Keyword(s):  
Adult Mouse ◽  
Thyroid Cells ◽  
Mouse Thyroid

Hyperpolarization of thyroid cells in vitro by thyrotropin and cyclic AMP

1976 ◽  
Vol 231 (1) ◽  
pp. 52-55 ◽  
Author(s):  
R Batt ◽  
JM McKenzie
Keyword(s):  
Cyclic Amp ◽  
Short Term ◽  
Thyroid Cells ◽  
Low Concentrations ◽  
Thyroid Glands ◽  
The Relationship ◽  
Effect Of Feeding ◽  
Mouse Thyroid

With the use of microelectrodes, membrane potential (MP) was measured in mouse thyroid glands in vitro. A basal resting MP of about -39 mV was confirmed. The initial effect of feeding a low-iodine diet (6-12 days) was hyperpolarization, up to -47 m V; chronic low-iodine diet led to depolarization. Low concentrations of thyrotropin (less than 3 mU/ml superfusate) caused hyperpolarization and high ones (greater than 10 mU/ml) led to depolarization. Cyclic AMP (10(-3) M), dibutyryl cyclic AMP (1.2 X 10(-4) M or 1.2 X 10(-3) M) and theophylline (10(-2) or 10(-3) M) caused similar hyperpolarization: D- and DL-propranolol (5 X 10(-5) -5 X 10(-4) M) produced depolarization and inhibited hyperpolarization by thyrotropin. Conclusions are that hyperpolarization is a consequence of short-term increased secretion of thyrotropin in vivo or of low (near physiological) concentrations in vitro; these effects are probably mediated by cyclic AMP. The relationship to and mechanism of depolarization resulting from chronic enhanced endogenous secretion or high in vitro concentrations of thyrotropin are unknown.

scholarly journals An Adult Mouse Thyroid Side Population Cell Line that Exhibits Enriched Epithelial–Mesenchymal Transition

Thyroid ◽  
2017 ◽  
Vol 27 (3) ◽  
pp. 460-474 ◽  
Author(s):  
Tsubasa Murata ◽  
Manabu Iwadate ◽  
Yoshinori Takizawa ◽  
Masaaki Miyakoshi ◽  
Suguru Hayase ◽  
...  
Keyword(s):  
Cell Line ◽  
Adult Mouse ◽  
Epithelial Mesenchymal Transition ◽  
Side Population ◽  
Side Population Cell ◽  
Mesenchymal Transition ◽  
Mouse Thyroid

Cell Growth Dynamics in Embryonic and Adult Mouse Thyroid Revealed by a Novel Approach to Detect Thyroid Gland Subpopulations

Thyroid ◽  
2016 ◽  
Vol 26 (4) ◽  
pp. 591-599 ◽  
Author(s):  
Sanjay Gawade ◽  
Carlos Mayer ◽  
Katrin Hafen ◽  
Thomas Barthlott ◽  
Werner Krenger ◽  
...  
Keyword(s):  
Cell Growth ◽  
Thyroid Gland ◽  
Adult Mouse ◽  
Growth Dynamics ◽  
Novel Approach ◽  
Mouse Thyroid

RELEASE OF CYCLIC AMP FROM THYROID CELLS IN VITRO

1978 ◽  
Vol 89 (4) ◽  
pp. 693-700 ◽  
Author(s):  
Bo Ahrén ◽  
Åsa Gustafson ◽  
Pavo Hedner ◽  
Hans Nilsson
Keyword(s):  
Cyclic Amp ◽  
Control Level ◽  
Camp Level ◽  
Cell Content ◽  
Thyroid Cells ◽  
Tissue Protein ◽  
Camp Levels ◽  
Mouse Thyroid ◽  
Quantitative Importance

ABSTRACT Half lobes of mouse thyroid gland were incubated in vitro with TSH. They released cyclic AMP (cAMP) into the medium in amounts depending on the concentration of TSH. The release of cAMP was greatest during the first hour of incubation, then it occurred at a lower rate. With an incubation time of 45 min the medium cAMP levels ranged from 43.0 ± 11.9 pmole per mg tissue protein for controls to 296.5 ± 29.2 pmole per mg tissue protein with 5 mU of TSH in the medium. The tissue cAMP level reached a maximum after 15–30 min of incubation with TSH, then it gradually decreased towards control level during 4 h of incubation. With 25 min of incubation the tissue cAMP level was 28.5 ± 8.8 pmole per mg tissue protein for controls compared to 194.3 ± 27.0 pmole per mg tissue protein with 5 mU TSH in the incubation medium. The release of thyroxine was of the same order during the later part of the 4 h incubation period compared to the first one. The results illustrate the quantitative importance of cAMP release, and the fact that in the later part of the incubaion period the cell content of cAMP was low while the release of thyroxine remained high.

Sox2 expression in the myenteric plexus in the caecum of postnatal and adult mouse

2016 ◽  
Vol 54 (08) ◽  
Author(s):  
D Grundmann ◽  
E Loris ◽  
L Aigner ◽  
S Couillard-Despres ◽  
KH Schäfer
Keyword(s):  
Myenteric Plexus ◽  
Adult Mouse ◽  
Sox2 Expression

Early change of thyroid hormone concentration after 131I treatment in patients with solitary toxic adenoma

2002 ◽  
Vol 41 (04) ◽  
pp. 178-183 ◽  
Author(s):  
V. Fidler ◽  
K. Zaletel ◽  
S. Gaberšček ◽  
S. Hojker ◽  
E. Pirnat
Keyword(s):  
Thyroid Hormone ◽  
Antithyroid Drugs ◽  
Prospective Clinical Study ◽  
Hormone Concentration ◽  
Toxic Adenoma ◽  
Free Triiodothyronine ◽  
Thyroid Cells ◽  
131I Treatment ◽  
Before And After ◽  
Thyroid Hormone Concentration

Summary Aim: In spite of extensive use of 131I for treatment of hyperthyroidism, the results of early outcome are variable. In our prospective clinical study we tested whether 131I induced necrosis causing clinical aggravation of hyperthyroidism and increasing the free thyroid hormone concentration in the serum of patients with solitary toxic adenoma not pretreated with antithyroid drugs. Patients and methods: 30 consecutive patients were treated with 925 MBq 131I. Serum concentration of thyrotropin (TSH), free thyroxine (fT4), free triiodothyronine (fT3), thyroglobulin (Tg), and interleukin-6 (IL-6) were measured before and after application of 131I. Results: After application of 131I no clinical worsening was observed. FT4 and fT3 concentration did not change significantly within the first five days, whereas both of them significantly decreased after 12 days (p <0.0001). Slight and clinically irrelevant increase in the level of the two thyroid hormones was observed in 9 patients. Furthermore, we observed a prolonged increase in Tg concentration and a transient increase in IL-6 concentration. Conclusion: Neither evidence of any clinical aggravation of hyperthyroidism nor any significant increase in thyroid hormone concentration by 131I induced necrosis of thyroid cells was found. Therefore, the application of 131I may be considered as a safe and effective treatment for patients with hyperthyroidism due to toxic adenoma.

Activation of Epac- and PKA-dependent signaling pathways by cAMP in FRTL5 thyroid cells

2006 ◽  
Vol 114 (S 1) ◽  
Author(s):  
M Bröcker-Preuss ◽  
M Bollepalli ◽  
M Schmidt ◽  
J Baten ◽  
K Mann
Keyword(s):  
Signaling Pathways ◽  
Thyroid Cells

Longterm Cultures of Sheep Thyroid Cells

1980 ◽  
Vol 92 (4_Suppla) ◽  
pp. 1-43 ◽  
Author(s):  
M.K. O'Connor ◽  
J.F. Malone ◽  
M.J. Cullen
Keyword(s):  
Thyroid Cells

Auto-antigen presentation of thyroid cells derived from autoimmune thyroid tissue

1985 ◽  
Vol 110 (1_Suppla) ◽  
pp. S83
Author(s):  
B. E. WENZEL ◽  
T. MANSKY ◽  
P. C. SCRIBA
Keyword(s):  
Antigen Presentation ◽  
Thyroid Tissue ◽  
Thyroid Cells ◽  
Autoimmune Thyroid
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