scholarly journals The Ukrainian-American Study of Leukemia and Related Disorders among Chornobyl Cleanup Workers from Ukraine: II. Estimation of Bone Marrow Doses

2008 ◽  
Vol 170 (6) ◽  
pp. 698 ◽  
Author(s):  
Vadim V. Chumak ◽  
Anatoly Ye Romanenko ◽  
Paul G. Voillequé ◽  
Elena V. Bakhanova ◽  
Natalya Gudzenko ◽  
...  
Radiology ◽  
1985 ◽  
Vol 156 (1) ◽  
pp. 51-56 ◽  
Author(s):  
B J McNeil ◽  
D Tihansky ◽  
J E Wennberg

1999 ◽  
Vol 53 (3) ◽  
pp. 189-197 ◽  
Author(s):  
Eduard Gershkevitsh ◽  
Ivan Rosenberg ◽  
David P. Dearnaley ◽  
Klaus-Rüdiger Trott

2018 ◽  
Vol 38 (4) ◽  
pp. 1359-1370
Author(s):  
Felipe Albornoz-Castañeda ◽  
Gloria Díaz-Londoño ◽  
Marcia García-Arencibia ◽  
Gianina Sirandoni-Riquelme

Blood ◽  
1962 ◽  
Vol 19 (4) ◽  
pp. 460-467 ◽  
Author(s):  
GEORGE S. HODGSON

Abstract The relation between bone marrow cell dose and 24-hour erythrocyte Fe59 uptake has been established in lethally irradiated mice. Erythrocyte Fe59 uptake is a function of the dose of bone marrow cells and of the time after irradiation at which Fe59 is injected. By choosing appropriate bone marrow doses and times of Fe59 injection, the range of cell doses between 5 x 105 and 2 x 107 has been explored. The relation between cell dose and Fe59 uptake is linear for Fe59 uptakes between 0 to 30 per cent. The steepest line relating Fe59 uptake to cell dose is that obtained when Fe59 was injected at day 9 and covers the range of 5 X 104 to 5 X 105 cells. The curve obtained when iron is injected on day 5 is much flatter and covers the range of 1 x 106 to 2 x 107 cells. Erythropoiesis stimulating factor (ESF) in doses that stimulate erythrocyte Fe59 uptake in normal mice has no effect in irradiated, bone marrow-treated mice. Homologous marrow is slightly less effective, and rat bone marrow markedly (∼ 100 times) less effective in promoting recovery of erythropoieis. The erythrocyte Fe59 uptake of mice preimmunized with homologous or rat marrow before irradiation is much lower than that of nonpreimmunized animals.


2008 ◽  
Vol 170 (6) ◽  
pp. 691-697 ◽  
Author(s):  
A. Romanenko ◽  
V. Bebeshko ◽  
M. Hatch ◽  
D. Bazyka ◽  
S. Finch ◽  
...  

2016 ◽  
Vol 38 (4) ◽  
pp. 242-244 ◽  
Author(s):  
N M Bilko ◽  
I S Dyagil ◽  
I S Russu ◽  
D I Bilko

High radiation sensitivity of stem cells and their ability to accumulate sublethal radiation damage provides the basis for investigation of hematopoietic progenitors using in vivo culture methodology. Unique samples of peripheral blood and bone marrow were derived from the patients affected by Chornobyl accident during liquidation campaign. Aim: To investigate functional activity of circulating hematopoietic progenitor cells from peripheral blood and bone marrow of cleanup workers in early and remote periods after the accident at Chornobyl nuclear power plant (CNPP). Materials and Methods: The assessment of the functional activity of circulating hematopoietic progenitor cells was performed in samples of peripheral blood and bone marrow of 46 cleanup workers, who were treated in the National Scientific Center for Radiation Medicine of the Academy of Medical Sciences of Ukraine alongside with 35 non radiated patients, who served as a control. Work was performed by culturing peripheral blood and bone marrow mononuclear cells in the original gel diffusion capsules, implanted into the peritoneal cavity of CBA mice. Results: It was shown that hematopoietic progenitor cells could be identified in the peripheral blood of liquidators of CNPP accident. At the same time the number of functionally active progenitor cells of the bone marrow was significantly decreased and during the next 10 years after the accident, counts of circulating progenitor cells in the peripheral blood as well as functionally active hematopoietic cells in bone marrow returned to normal levels. Conclusion: It was shown that hematopoietic progenitor cells are detected not only in the bone marrow but also in the peripheral blood of liquidators as a consequence of radiation exposure associated with CNPP accident. This article is a part of a Special Issue entitled “The Chornobyl Nuclear Accident: Thirty Years After”.


2018 ◽  
Vol 52 ◽  
pp. 60
Author(s):  
John Stratakis ◽  
Georgia Solomou ◽  
Antonios Papadakis ◽  
Kostas Perisinakis ◽  
John Damilakis

2008 ◽  
Vol 170 (6) ◽  
pp. 711-720 ◽  
Author(s):  
Anatoly Ye Romanenko ◽  
Stuart C. Finch ◽  
Maureen Hatch ◽  
Jay H. Lubin ◽  
Volodymyr G. Bebeshko ◽  
...  

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