Biochemical Alterations in Human Cells Irradiated with α Particles Delivered by Macro- or Microbeams

2007 ◽  
Vol 167 (5) ◽  
pp. 551-562 ◽  
Author(s):  
Nathalie Gault ◽  
Odile Rigaud ◽  
Jean-Luc Poncy ◽  
Jean-Louis Lefaix
Keyword(s):  
Human Cells ◽  
Biochemical Alterations ◽  
Α Particles

Sulfur Mustard-Induced Biochemical Alterations in Proliferating Human Cells in Culture

1992 ◽  
Vol 11 (4) ◽  
pp. 293-304 ◽  
Author(s):  
William J. Smith ◽  
Kenneth M. Sanders ◽  
James E. Caulfield ◽  
Clark L. Gross
Keyword(s):  
Sulfur Mustard ◽  
Human Cells ◽  
Biochemical Alterations ◽  
Cells In Culture

scholarly journals Chromosome Damage in Human Cells by γ Rays, α Particles and Heavy Ions: Track Interactions in Basic Dose-Response Relationships

2012 ◽  
Vol 179 (1) ◽  
pp. 9 ◽  
Author(s):  
Bradford D. Loucas ◽  
Marco Durante ◽  
Susan M. Bailey ◽  
Michael N. Cornforth
Keyword(s):  
Dose Response ◽  
Heavy Ions ◽  
Human Cells ◽  
Chromosome Damage ◽  
Γ Rays ◽  
Α Particles

Transcriptional response of human cells to microbeam irradiation with 2.1MeV α-particles

2007 ◽  
Vol 39 (6) ◽  
pp. 1056-1065 ◽  
Author(s):  
C.E. Hellweg ◽  
L. Spitta ◽  
A. Arenz ◽  
S.C. Bogner ◽  
R. Ruscher ◽  
...  
Keyword(s):  
Transcriptional Response ◽  
Human Cells ◽  
Microbeam Irradiation ◽  
Α Particles

The Morphology of the Rat Kidney Following Folic Acid Administration

1970 ◽  
Vol 28 ◽  
pp. 200-201
Author(s):  
Aline Byrnes ◽  
Elsa E. Ramos ◽  
Minoru Suzuki ◽  
E.D. Mayfield
Keyword(s):  
Folic Acid ◽  
De Novo ◽  
Specific Activity ◽  
Rat Kidney ◽  
Present Report ◽  
Intracellular Localization ◽  
Male Rats ◽  
Renal Hypertrophy ◽  
Electron Microscopic ◽  
Biochemical Alterations

Renal hypertrophy was induced in 100 g male rats by the injection of 250 mg folic acid (FA) dissolved in 0.3 M NaHCO3/kg body weight (i.v.). Preliminary studies of the biochemical alterations in ribonucleic acid (RNA) metabolism of the renal tissue have been reported recently (1). They are: RNA content and concentration, orotic acid-c14 incorporation into RNA and acid soluble nucleotide pool, intracellular localization of the newly synthesized RNA, and the specific activity of enzymes of the de novo pyrimidine biosynthesis pathway. The present report describes the light and electron microscopic observations in these animals. For light microscopy, kidney slices were fixed in formalin, embedded, sectioned, and stained with H & E and PAS.

Alignment of small He-Bubbles during in situ deformation of Al-foils

1978 ◽  
Vol 36 (1) ◽  
pp. 396-397
Author(s):  
E. Ruedl ◽  
P. Schiller
Keyword(s):  
Fusion Reactor ◽  
Matrix Material ◽  
Fusion Reactors ◽  
First Wall ◽  
Potential Matrix ◽  
In Situ Deformation ◽  
Α Particles ◽  
Metal Aluminium

The low Z metal aluminium is a potential matrix material for the first wall in fusion reactors. A drawback in the application of A1 is the rel= atively high amount of He produced in it under fusion reactor conditions. Knowledge about the behaviour of He during irradiation and deformation in Al, especially near the surface, is therefore important.Using the TEM we have studied Al disks of 3 mm diameter and 0.2 mm thickness, which were perforated at the centre by double jet polishing. These disks were bombarded at∽200°C to various doses with α-particles, impinging at any angle and energy up to 1.5 MeV at both surfaces. The details of the irradiations are described in Ref.1. Subsequent observation indicated that in such specimens uniformly distributed He-bubbles are formed near the surface in a layer several μm thick (Fig.1).After bombardment the disks were deformed at 20°C during observation by means of a tensile device in a Philips EM 300 microscope.

Alpha-Tocopherol Protects Cultured Human Cells from the Acute Lethal Cytotoxicity of Dioxin

2002 ◽  
Vol 72 (3) ◽  
pp. 147-153 ◽  
Author(s):  
Kei-Ichi Hirai ◽  
Jie-Hong Pan ◽  
Ying-Bo Shui ◽  
Eriko Simamura ◽  
Hiroki Shimada ◽  
...  
Keyword(s):  
Cell Death ◽  
Cell Damage ◽  
Smooth Endoplasmic Reticulum ◽  
Dehydroascorbic Acid ◽  
Human Cells ◽  
Alpha Tocopherol ◽  
Cervical Cancer Cells ◽  
Cultured Human Cells ◽  
Nuclear Damage ◽  
Conjunctival Epithelial Cells

The possible protection of cultured human cells from acute dioxin injury by antioxidants was investigated. The most potent dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), caused vacuolization of the smooth endoplasmic reticulum and Golgi apparatus in cultured human conjunctival epithelial cells and cervical cancer cells. Subsequent nuclear damage included a deep irregular indentation resulting in cell death. A dosage of 30–40 ng/mL TCDD induced maximal intracellular production of H2O2 at 30 minutes and led to severe cell death (0–31% survival) at two hours. A dose of 1.7 mM alpha-tocopherol or 1 mM L-dehydroascorbic acid significantly protected human cells against acute TCDD injuries (78–97% survivals), but vitamin C did not provide this protection. These results indicate that accidental exposure to fatal doses of TCDD causes cytoplasmic free radical production within the smooth endoplasmic reticular systems, resulting in severe cytotoxicity, and that vitamin E and dehydroascorbic acid can protect against TCDD-induced cell damage.

Chromium oxidation state mapping in human cells

2003 ◽  
Vol 104 ◽  
pp. 289-292 ◽  
Author(s):  
R. Ortega ◽  
B. Fayard ◽  
M. Salomé ◽  
G. Devès ◽  
J. Susini
Keyword(s):  
Oxidation State ◽  
Human Cells ◽  
Chromium Oxidation

Trichosanthes dioica mediated biochemical alterations in STZ induced diabetic rats

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
DK Rai ◽  
PK Rai ◽  
B Sharma ◽  
G Watal
Keyword(s):  
Diabetic Rats ◽  
Biochemical Alterations ◽  
Trichosanthes Dioica

Transport of clozapine and its major metabolites into human cells of glial and neuronal origin

2004 ◽  
Vol 36 (05) ◽  
Author(s):  
U Henning ◽  
K Krieger ◽  
S Loeffler ◽  
A Klimke
Keyword(s):  
Human Cells
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