NAÏVE-POOLED PHARMACOKINETICS OF CEFTIOFUR CRYSTALLINE FREE ACID AFTER SINGLE INTRAMUSCULAR ADMINISTRATION IN SMOOTH DOGFISH (MUSTELUS CANIS)

2019 ◽  
Vol 50 (2) ◽  
pp. 466
Author(s):  
Melissa A. Fayette
Keyword(s):  
Free Acid ◽  
Intramuscular Administration ◽  
Mustelus Canis

PHARMACOKINETICS OF CEFTIOFUR CRYSTALLINE FREE ACID STERILE SUSPENSION IN GREEN IGUANAS (IGUANA IGUANA) AFTER SINGLE INTRAMUSCULAR ADMINISTRATION

2018 ◽  
Vol 49 (1) ◽  
pp. 86-91 ◽  
Author(s):  
Miranda J. Sadar ◽  
Michelle G. Hawkins ◽  
Ian T. Taylor ◽  
Barbara A. Byrne ◽  
Lisa A. Tell
Keyword(s):  
Free Acid ◽  
Intramuscular Administration ◽  
Iguana Iguana ◽  
Green Iguanas

Calcium ion imaging in plant cells

1993 ◽  
Vol 51 ◽  
pp. 132-133
Author(s):  
Peter K. Hepler ◽  
Dale A. Callaham
Keyword(s):  
Plant Cell Wall ◽  
Cytoplasmic Membrane ◽  
Fluorescent Dyes ◽  
Free Acid ◽  
Methyl Esters ◽  
Free Calcium ◽  
Local Concentration ◽  
Ion Imaging ◽  
Membrane Compartments ◽  
Free Acid Form

Calcium ions (Ca) participate in many signal transduction processes, and for that reason it is important to determine where these ions are located within the living cell, and when and to what extent they change their local concentration. Of the different Ca-specific indicators, the fluorescent dyes, developed by Grynkiewicz et al. (1), have proved most efficacious, however, their use on plants has met with several problems (2). First, the dyes as acetoxy-methyl esters are often cleaved by extracellular esterases in the plant cell wall, and thus they do not enter the cell. Second, if the dye crosses the plasma membrane it may continue into non-cytoplasmic membrane compartments. Third, even if cleaved by esterases in the cytoplasm, or introduced as the free acid into the cytoplasmic compartment, the dyes often become quickly sequestered into vacuoles and organelles, or extruded from the cell. Finally, the free acid form of the dye readily complexes with proteins reducing its ability to detect free calcium. All these problems lead to an erroneous measurement of calcium (2).

TRANSFORMATION OF Δ5-ANDROSTENE-3,17-DIONE TO A Δ5-3α-HYDROXYSTEROID IN MAN

1962 ◽  
Vol 41 (3) ◽  
pp. 391-394 ◽  
Author(s):  
David K. Fukushima ◽  
Kenneth I. H. Williams ◽  
Barnett Zumoff ◽  
T. F. Gallagher
Keyword(s):  
Intramuscular Administration ◽  
No Conversion

ABSTRACT 3α-Hydroxy-Δ5-androsten-17-one has been isolated following intramuscular administration of Δ5-androstene-3,17-dione to man. There was very little or no conversion to 3β-hydroxy-Δ5 epimer. Significant amounts of androsterone and aetiocholanolone were obtained.

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